Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 σ gene in human hepatocellular carcinoma

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

Regulation ofp53downstream genes

1998 • 777 citations

Aging and DNA methylation in colorectal mucosa and cancer.

1998 • 620 citations

Hepatocellular carcinoma: Recent progress

1992 • 536 citations

High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer

2000 • 442 citations

Association of the Cyclin-dependent Kinases and 14-3-3 Sigma Negatively Regulates Cell Cycle Progression

2000 • 305 citations

Dependence of transcriptional repression on CpG methylation density.

1994 • 294 citations

Cell-cycle regulators and cancer

1995 • 291 citations

Comprehensive allelotyping of human hepatocellular carcinoma

1997 • 285 citations

Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis.

1998 • 237 citations

p16INK4 is inactivated by extensive CpG methylation in human hepatocellular carcinoma

1999 • 207 citations

Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation.

1997 • 205 citations

Genetic Aspects of Hepatocellular Carcinogenesis

1999 • 193 citations

Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus

1998 • 192 citations

High frequency of p16INK4A gene alterations in hepatocellular carcinoma

1999 • 179 citations

Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.

1992 • 149 citations

Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma.

1999 • 128 citations

Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis

2000 • 113 citations

Dependence of Transcriptional Repression on CpG Methylation Density

1994 • 112 citations

Germ-line mutations of thep16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma

1997 • 85 citations

Cloning of putative growth regulatory genes from primary human keratinocytes by subtractive hybridization

1995 • 70 citations

Stratifin, a keratinocyte specific 14-3-3 protein, harbors a pleckstrin homology (ph) domain and enhances protein kinase c activity

1995 • 68 citations

DNA Methylation Analysis Using Bisulfite Treatment and PCR–Single-Strand Conformation Polymorphism in Colorectal Cancer Showing Microsatellite Instability

1999 • 57 citations

Establishment of Epstein‐Barr Virus‐positive Human Gastric Epithelial Cell Lines

1998 • 40 citations

Characterization of colonic polyps by two-dimensional gel electrophoresis

1999 • 39 citations

Alteration of cell cycle-related genes in hepatocarcinogenesis.

1997 • 33 citations

Complex Methylation Patterns Analyzed by Single-Strand Conformation Polymorphism

1999 • 26 citations

Quantitative DNA methylation analysis by fluorescent polymerase chain reaction single-strand conformation polymorphism using an automated DNA sequencer

2000 • 23 citations

Asteroidal defence

1999 • 1 citations