Chk1 promotes replication fork progression by controlling replication initiation

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 • 2,569 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

1997 • 1,324 citations

The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

2001 • 1,051 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

Replicon Clusters Are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in Human Cells

1998 • 815 citations

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

2010 • 779 citations

Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stress

2007 • 568 citations

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

2005 • 521 citations

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

2008 • 482 citations

Regulation of Replication Fork Progression Through Histone Supply and Demand

2007 • 454 citations

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G ₂ checkpoints

2002 • 446 citations

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

2000 • 412 citations

ATR and ATM regulate the timing of DNA replication origin firing

2004 • 375 citations

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase

2005 • 342 citations

Dynamics of DNA Replication in Mammalian Somatic Cells

2003 • 323 citations

Activation of mammalian Chk1 during DNA replication arrest

2001 • 307 citations

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

2003 • 243 citations

An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

2002 • 242 citations

Chk1 regulates the density of active replication origins during the vertebrate S phase

2007 • 232 citations

Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells

2003 • 226 citations

Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G₂/M Checkpoint

2004 • 222 citations

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

2008 • 211 citations

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

2008 • 207 citations

Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase

2006 • 173 citations

XRCC3 and Rad51 Modulate Replication Fork Progression on Damaged Vertebrate Chromosomes

2003 • 165 citations

Regulating the licensing of DNA replication origins in metazoa

2006 • 165 citations

Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells

2004 • 137 citations

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

2008 • 130 citations

ATR, Claspin and the Rad9-Rad1-Hus1 Complex Regulate Chk1 and Cdc25A in the Absence of DNA Damage

2004 • 118 citations

Plx1 is required for chromosomal DNA replication under stressful conditions

2008 • 117 citations

Claspin Promotes Normal Replication Fork Rates in Human Cells

2008 • 108 citations

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint

2007 • 92 citations

Identification and characterization of a human protein kinase related to budding yeast Cdc7p

1997 • 86 citations

Cdc7 Is an Active Kinase in Human Cancer Cells Undergoing Replication Stress

2006 • 80 citations

Cdc7 kinase – A new target for drug development

2009 • 75 citations

Cdc7-Dbf4 and the Human S Checkpoint Response to UVC

2007 • 74 citations

Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress

2007 • 69 citations

Regulation of Cellular and SV40 Virus Origins of Replication by Chk1-dependent Intrinsic and UVC Radiation-induced Checkpoints

2003 • 59 citations

Cdk Inhibition in Human Cells Compromises Chk1 Function and Activates a DNA Damage Response

2005 • 58 citations