Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

A Third-Generation Lentivirus Vector with a Conditional Packaging System

1998 • 3,175 citations

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

2002 • 2,019 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

The importance of repairing stalled replication forks

2000 • 1,054 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains

1997 • 958 citations

ATR and ATRIP: Partners in Checkpoint Signaling

2001 • 935 citations

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

2000 • 922 citations

The many substrates and functions of ATM

2000 • 777 citations

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

2002 • 773 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

The DNA replication checkpoint response stabilizes stalled replication forks

2001 • 740 citations

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1998 • 533 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

2002 • 492 citations

Two Molecularly Distinct G₂/M Checkpoints Are Induced by Ionizing Irradiation

2002 • 467 citations

ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

2002 • 443 citations

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

1992 • 417 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

2000 • 412 citations

Improved properties of FLP recombinase evolved by cycling mutagenesis

1998 • 406 citations

Fission yeast genes involved in coupling mitosis to completion of DNA replication.

1992 • 382 citations

Replication Checkpoint Enforced by Kinases Cds1 and Chk1

1998 • 317 citations

Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX

2000 • 315 citations

ATR inhibition selectively sensitizes G ₁ checkpoint-deficient cells to lethal premature chromatin condensation

2001 • 289 citations

The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts

1998 • 244 citations

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

2000 • 196 citations

Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage

2000 • 164 citations

Checkpoint activation regulates mutagenic translesion synthesis

2003 • 159 citations

Mitotic Histone H3 Phosphorylation by the NIMA Kinase in Aspergillus nidulans

2000 • 158 citations

Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors.

1995 • 123 citations

ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint

2002 • 96 citations