Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation

1991 • 1,123 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

Hhal methyltransferase flips its target base out of the DNA helix

1994 • 936 citations

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

1993 • 739 citations

RESTRICTION AND MODIFICATION SYSTEMS

1991 • 702 citations

A nucleotide-flipping mechanism from the structure of human uracil–DNA glycosylase bound to DNA

1996 • 576 citations

Predictive motifs derived from cytosine methyltransferases

1989 • 505 citations

Structure-guided Analysis Reveals Nine Sequence Motifs Conserved among DNA Amino-methyl-transferases, and Suggests a Catalytic Mechanism for these Enzymes

1995 • 473 citations

How do serine proteases really work?

1989 • 456 citations

Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation

1994 • 448 citations

Crystal structure of catechol O-methyltransferase

1994 • 426 citations

The DNA (cytosine-5) methyltransferases

1994 • 425 citations

Refined crystal structure of carboxypeptidase a at 1·54 Å resolution

1983 • 391 citations

Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution

1989 • 375 citations

The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing

1995 • 366 citations

Genes-in-Pieces Revisited

1985 • 362 citations

Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine

1993 • 357 citations

Crystal structure of the met represser–operator complex at 2.8 Å resolution reveals DNA recognition by β-strands

1992 • 296 citations

Atomic model of a pyrimidine dimer excision repair enzyme complexed with a dna substrate: Structural basis for damaged DNA recognition

1995 • 270 citations

Universal Catalytic Domain Structure of AdoMet-dependent Methyltransferases

1995 • 243 citations

Cytosine-specific type II DNA methyltransferases

1989 • 230 citations

Correct Folding of Circularly Permuted Variants of a βα Barrel Enzyme in Vivo

1989 • 211 citations

Structure of PvuII endonuclease with cognate DNA.

1994 • 205 citations

Relation between structure and function of α/β–protejns

1980 • 194 citations

On base flipping

1995 • 173 citations

Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine.

1994 • 168 citations

Enzymatic C5-Cytosine Methylation of DNA: Mechanistic Implications of New Crystal Structures forHhaI Methyltransferase-DNA-AdoHcy Complexes

1996 • 166 citations

Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases

1989 • 152 citations

Crystal structure of the chemotaxis receptor methyltransferase CheR suggests a conserved structural motif for binding S-adenosylmethionine

1997 • 142 citations

Cloning of a restriction-modification system from Proteus vulgaris and its use in analyzing a methylase-sensitive phenotype in Escherichia coli

1985 • 141 citations

Targeted Base Stacking Disruption by the EcoRI DNA Methyltransferase

1996 • 131 citations

The structure of the C-terminal domain of methionine synthase: presenting S-adenosylmethionine for reductive methylation of B12

1996 • 120 citations

Evolution of type II DNA methyltransferases

1989 • 110 citations

Nucleotide sequence and expression of the gene encoding theEcoRII modification enzyme

1987 • 106 citations

Crystal structure of PvuII endonuclease reveals extensive structural homologies to EcoRV

1994 • 105 citations

Structure of the l-arabinose-binding protein from Escherichia coli at 2.4 Å resolution

1981 • 104 citations

Finding a basis for flipping bases

1996 • 104 citations

Crystal Structure of Glycine N-Methyltransferase from Rat Liver^,

1996 • 96 citations

Random circular permutation of genes and expressed polypeptide chains: application of the method to the catalytic chains of aspartate transcarbamoylase.

1996 • 94 citations

Relation between hen egg white lysozyme and bacteriophage T4 lysozyme: Evolutionary implications

1981 • 93 citations

A Structural Basis for the Preferential Binding of Hemimethylated DNA byHhaI DNA Methyltransferase

1996 • 91 citations

Allosteric and catalytic binding of S-adenosylmethionine to Escherichia coli DNA adenine methyltransferase monitored by 3H NMR.

1991 • 83 citations

DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase

1997 • 79 citations

A fully active variant of dihydrofolate reductase with a circularly permuted sequence

1992 • 75 citations

Common evolutionary origin of the phage T4 dam and host Escherichia coli dam DNA-adenine methyltransferase genes

1985 • 74 citations

Data collection and processing

1999 • 74 citations

Native-like in vivo folding of a circularly permuted jellyroll protein shown by crystal structure analysis.

1994 • 67 citations

Two new restriction endonucleases from Proteus vulgaris

1981 • 65 citations

The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coli

1990 • 64 citations

On the mechanism of DNA-adenine methylase.

1988 • 62 citations

Agmenellum quadruplicatum M.AquI, a novel modification methylase

1990 • 51 citations

[24] Amino acid sequence arrangements of DNA-methyltransferases

1992 • 51 citations

Stereochemical studies of the C-methylation of deoxycytidine catalyzed by Hha I methylase and the N-methylation of deoxyadenosine catalyzed by EcoRI methylase

1991 • 49 citations

Sequence, internal homology and high-level expression of the gene for a DNA-(cytosineN4)-methyltransferase, M-PvuII

1989 • 41 citations

Interaction of AluI, Cfr6I and PvuII restriction-modification enzymes with substrates containing either N4-methylcytosine or 5-methylcytosine

1987 • 38 citations

A model for DNA binding and enzyme action derived from crystallographic studies of the TaqI N6-adenine-methyltransferase

1995 • 33 citations

A bacterial methyltransferase M.EcoHK31I requires two proteins forin vitromethylation

1995 • 23 citations

Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis.

1993 • 23 citations

Is The Continuity of the Domains Required for the Correct Folding of a Two-Domain Protein?

1995 • 15 citations

Duplication and variation as a phylogenetic principle of type-II DNA methyltransferases

1988 • 4 citations

Statistical significance of amino acid sequence similarity in type II DNA methyltransferases.

1994 • 1 citations