The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function¹

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

1996 • 1,477 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions

1997 • 827 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.

1993 • 457 citations

Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression

1993 • 440 citations

Detection and characterization of high affinity plasma membrane receptors for human interleukin 1.

1985 • 397 citations

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

1994 • 394 citations

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma.

1995 • 355 citations

Glucocorticoid Resistance in Chronic Asthma: Glucocorticoid Pharmacokinetics, Glucocorticoid Receptor Characteristics, and Inhibition of Peripheral Blood T Cell Proliferation by GlucocorticoidsIn Vitro

1991 • 255 citations

Α Review on the Acute Phase Response in Major Depression

1993 • 227 citations

Characterization of Early Cytokine Responses and an Interleukin (IL)-6–dependent Pathway of Endogenous Glucocorticoid Induction during Murine Cytomegalovirus Infection

1997 • 212 citations

Antiinflammatory steroid action: Basic and clinical aspects

1990 • 202 citations

Modulation of glucocorticoid receptor function by protein kinase A.

1992 • 162 citations

Corticosterone regulation of Type I and Type II adrenal steroid receptors in brain, pituitary, and immune tissue

1991 • 157 citations

A novel action of IL-13: induction of diminished monocyte glucocorticoid receptor-binding affinity.

1996 • 156 citations

Steroid-Independent Translocation of the Glucocorticoid Receptor by the Antidepressant Desipramine

1997 • 155 citations

Endogenous Glucocorticoids Protect Against Cytokine-Mediated Lethality During Viral Infection

1999 • 149 citations

Novel Antipeptide Antibodies to the Human Glucocorticoid Receptor: Recognition of Multiple Receptor Formsin Vitroand Distinct Localization of Cytoplasmic and Nuclear Receptors

1990 • 140 citations

Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.

1993 • 128 citations

Glucocorticoid Receptors Are Differentially Expressed in the Cells and Tissues of the Immune System

1998 • 125 citations

Cyclic AMP-dependent protein kinase promotes glucocorticoid receptor function.

1986 • 97 citations

Intracellular traffic of steroid hormone receptors

1996 • 96 citations

Interleukin 1: a regulatory role in glucocorticoid-regulated hepatic metabolism.

1986 • 95 citations

Adrenal steroid receptor binding in spleen and thymus after stress or dexamethasone.

1990 • 89 citations

Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking.

1996 • 88 citations

Interleukin-1-induced Calcium Flux in Human Fibroblasts Is Mediated through Focal Adhesions

1995 • 80 citations

Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor.

1995 • 79 citations

Reduced glucocorticoid binding affinity in asthma is related to ongoing allergic inflammation.

1995 • 75 citations

Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis.

1996 • 75 citations

Cytokine induction of heat shock protein expression in human oligodendrocytes: An interleukin-1-mediated mechanism

1994 • 71 citations

Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock.

1994 • 68 citations

Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma☆☆☆★★★

1996 • 66 citations

Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.

1989 • 65 citations

Lipopolysaccharide increases glucocorticoid receptor expression in murine macrophages. A possible mechanism for glucocorticoid-mediated suppression of endotoxicity.

1992 • 59 citations

Human recombinant IL-1 alters glucocorticoid receptor function in Reuber hepatoma cells.

1988 • 58 citations

Changes of Pulmonary Glucocorticoid Receptor and Phospholipase A₂in Sheep with Acute Lung Injury after High Dose Endotoxin Infusion

1993 • 50 citations

Modulation of glucocorticoid receptor expression in human bronchial epithelial cell lines by IL-1 beta, TNF-alpha and LPS

1996 • 50 citations

Down regulation of hepatic glucocorticoid receptors after endotoxin treatment

1983 • 42 citations

Effects of Bacterial Endotoxin on the Glucocorticoid Feedback Regulation of Adrenocortical Response to Stress

1996 • 42 citations

Adrenal steroid receptor activation in vivo and immune function

1991 • 37 citations

Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome.

1996 • 30 citations

The Glucocorticoid Insensitivity Syndrome

1996 • 27 citations

Cytokine Networks and Corticosteroid Receptors

1995 • 25 citations

Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome

1996 • 20 citations

Monokines Mediate Decreased Hepatic Glucocorticoid Binding in Endotoxemia

1987 • 14 citations

Alterations in the number of glucocorticoid receptors of circulating lymphocytes in sepsis.

1986 • 5 citations