Interleukin-1-induced Calcium Flux in Human Fibroblasts Is Mediated through Focal Adhesions

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

A simple method of reducing the fading of immunofluorescence during microscopy

1981 • 1,907 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

A thousand and one protein kinases

1987 • 1,066 citations

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

1984 • 1,042 citations

An interleukin 1 like factor stimulates bone resorption in vitro

1983 • 1,017 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Interleukin 1, a potential regulator of fibroblast proliferation.

1982 • 835 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

The Calcium Messenger System

1986 • 669 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Detection and characterization of high affinity plasma membrane receptors for human interleukin 1.

1985 • 397 citations

Interleukin 1 stimulation of collagenase production by cultured fibroblasts.

1983 • 373 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

The Calcium Messenger System

1986 • 275 citations

Dependence of collagen remodelling on α‐smooth muscle actin expression by fibroblasts

1994 • 275 citations

Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family.

1991 • 259 citations

Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.

1993 • 242 citations

Properties of a specific interleukin 1 (IL 1) receptor on human Epstein Barr virus-transformed B lymphocytes: identity of the receptor for IL 1-alpha and IL 1-beta.

1986 • 225 citations

Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells

1986 • 219 citations

Binding and internalization of interleukin 1 by T cells. Direct evidence for high- and low-affinity classes of interleukin 1 receptor.

1986 • 194 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Interleukin-1 Has Independent Effects on Deoxyribonucleic Acid and Collagen Synthesis in Cultures of Rat Calvariae*

1986 • 179 citations

Focal adhesion kinase: an integrin-linked protein tyrosine kinase

1993 • 177 citations

Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.

1987 • 157 citations

Binding, internalization, and intracellular localization of interleukin-1 beta in human diploid fibroblasts.

1988 • 156 citations

The role of calcium in lymphocyte proliferation. (An interpretive review)

1983 • 151 citations

Quantitation of actin polymerization in two human fibroblast sub-types responding to mechanical stretching

1991 • 149 citations

Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells

1992 • 148 citations

Identification of a high-affinity receptor for native human interleukin 1 beta and interleukin 1 alpha on normal human lung fibroblasts.

1987 • 132 citations

Human recombinant interleukin 1 beta has no effect on intracellular calcium or on functional responses of human neutrophils.

1987 • 131 citations

Cyclic AMP and interleukin 1 signal transduction

1990 • 107 citations

Bioassay of interleukin 1 (IL-1) in human gingival crevicular fluid during experimental gingivitis

1992 • 104 citations

Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes.

1992 • 87 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

1988 • 86 citations

Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch

1994 • 79 citations

Interleukin 1 beta induces rapid phosphorylation and redistribution of talin: a possible mechanism for modulation of fibroblast focal adhesion.

1991 • 78 citations

IL-1 induces rapid phosphorylation of the IL-1 receptor.

1989 • 74 citations

Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1

1988 • 73 citations

Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).

1990 • 68 citations

Channel Regulation: Ion channel control by tyrosine phosphorylation

1994 • 62 citations

Biology of the Interleukin-1 Receptor

1990 • 53 citations

Effect of interleukin-1 on intracellular concentration of sodium, calcium, and potassium in 70Z/3 cells.

1986 • 52 citations

Introduction of large molecules into viable fibroblasts by electroporation: Optimization of loading and identification of labeled cellular compartments

1992 • 51 citations

Immunophysiology: The role of cells and cytokines in immunity and inflammation

1991 • 30 citations

Effect of a interleukin-I like factor (mononuclear cell factor) on proteoglycan synthesis in cultured human articular chondrocytes

1986 • 28 citations

Fibroblastic regulation of osteoblast function by prostaglandins

1992 • 27 citations

Effects of interleukin‐1 on fibroblast extracellular matrix, using a 3‐dimensional culture system

1989 • 24 citations

Interleukin 2 stimulates T cell proliferation using a calcium flux

1985 • 24 citations

A STUDY OF THE EFFECTS OF CATABOLIN ON CYCLIC ADENOSINE MONOPHOSPHATE BIOSYNTHESIS AND PROSTAGLANDIN E2 SECRETION IN PIG ARTICULAR CHONDROCYTES

1986 • 22 citations

Effects of natural and recombinant interleukin-1 alpha and -beta on cytosolic free calcium in human and murine fibroblasts.

1988 • 18 citations

Does Interleukin-1 affect intracellular calcium in osteoblast-like cells (UMR-106)?

1988 • 17 citations

The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production.

1992 • 17 citations

An interleukin-1 inhibitor in gingival crevicular fluid of patients with chronic inflammatory periodontal disease

1991 • 10 citations

Interleukin-1 and synovial protein kinase C: Identification of a novel, 35 kDa cytosolic substrate

1991 • 4 citations