Diminished Cell Proliferation Associated with the Death-protective Activity of Bcl-2

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Mitosis in transition

1994 • 745 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Inhibition of apoptosis by the retinoblastoma gene product.

1995 • 286 citations

Cell cycle checkpoints

1994 • 284 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin.

1991 • 257 citations

Cell death in health and disease: the biology and regulation of apoptosis

1995 • 245 citations

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

1992 • 245 citations

Ornithine Decarboxylase Is a Mediator of c-Myc-Induced Apoptosis

1994 • 238 citations

Apoptosis Biochemical events and relevance to cancer chemotherapy

1992 • 238 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells.

1993 • 157 citations

Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation.

1990 • 144 citations

Lymphoma models for B cell activation and tolerance. III. Cell cycle dependence for negative signalling of WEHI-231 B lymphoma cells by anti-mu.

1986 • 112 citations

Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death.

1994 • 103 citations

Cell growth and apoptosis: a practical approach

1997 • 93 citations

Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.

1991 • 76 citations

Anti-IgM antibody-induced cell death in a human B lymphoma cell line, B104, represents a novel programmed cell death.

1992 • 73 citations

Apoptosis induced by serum deprivation of PC12 cells is not preceded by growth arrest and can occur at each phase of the cell cycle.

1995 • 72 citations

Growth factor starvation of bcl-2 overexpressing murine bone marrow cells induced refractoriness to IL-3 stimulation of proliferation.

1994 • 67 citations

Anti-immunoglobulin treatment of murine B-cell lymphomas induces active transforming growth factor beta but pRB hypophosphorylation is transforming growth factor beta independent.

1992 • 55 citations

Antigen-Induced Programmed T Cell Death as a New Approach to Immune Therapy

1995 • 39 citations

Growth factor‐induced DNA synthesis in cells that overproduce protein kinase C

1990 • 25 citations

Neoplastic Changes Involving Follicles: Morphological, Immunophenotypic and Genetic Diversity of Lymphoproliferations Derived from Germinal Center and Mantle Zone

1992 • 22 citations