Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

Phagocytes and oxidative stress

2000 • 1,055 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

Studies on the chlorinating activity of myeloperoxidase.

1976 • 918 citations

Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System

1968 • 840 citations

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1998 • 686 citations

ANIMAL MODELS OF SEPSIS AND SHOCK

1998 • 577 citations

Oxidants and free radicals in inflammatory bowel disease

1994 • 512 citations

Thiocyanate and chloride as competing substrates for myeloperoxidase

1997 • 392 citations

Brominating Oxidants Generated by Human Eosinophils

1986 • 364 citations

[40] Preparation and characterization of chloramines

1986 • 345 citations

Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

1970 • 345 citations

Apoptosis in lymphoid and parenchymal cells during sepsis

1997 • 335 citations

Increased atherosclerosis in myeloperoxidase-deficient mice

2001 • 319 citations

Severe Impairment in Early Host Defense againstCandida albicansin Mice Deficient in Myeloperoxidase

1999 • 304 citations

Myeloperoxidase

1999 • 294 citations

Eosinophils generate brominating oxidants in allergen-induced asthma

2000 • 279 citations

Myeloperoxidase

2000 • 261 citations

Human neutrophils employ chlorine gas as an oxidant during phagocytosis.

1996 • 258 citations

Leukocytic Oxygen Activation and Microbicidal Oxidative Toxin

1989 • 225 citations

3-Bromotyrosine and 3,5-Dibromotyrosine Are Major Products of Protein Oxidation by Eosinophil Peroxidase: Potential Markers for Eosinophil-Dependent Tissue Injury in Vivo

1999 • 176 citations

Oxidation of Bromide by the Human Leukocyte Enzymes Myeloperoxidase and Eosinophil Peroxidase

1995 • 174 citations

Eosinophils Preferentially Use Bromide to Generate Halogenating Agents

1989 • 148 citations

Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts

2000 • 135 citations

Eosinophil Peroxidase Oxidation of Thiocyanate

2001 • 127 citations

Production of Brominating Intermediates by Myeloperoxidase

2001 • 116 citations

Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice

1999 • 112 citations

p-Hydroxyphenylacetaldehyde Is the Major Product of L-Tyrosine Oxidation by Activated Human Phagocytes

1996 • 103 citations

8-Nitro-2‘-deoxyguanosine, a Specific Marker of Oxidation by Reactive Nitrogen Species, Is Generated by the Myeloperoxidase−Hydrogen Peroxide−Nitrite System of Activated Human Phagocytes

1999 • 103 citations

Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: Sensitive and quantitative assays for oxidized amino acids in proteins and tissues

1999 • 95 citations

Large-Scale Purification of Myeloperoxidase from HL60 Promyelocytic Cells: Characterization and Comparison to Human Neutrophil Myeloperoxidase

2000 • 39 citations

Myeloperoxidase deficiency

2011 • 26 citations

The eosinophil peroxidase gene forms a cluster with the genes for myeloperoxidase and lactoperoxidase on human chromosome 17

2000 • 25 citations

Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis

2000 • 18 citations