The biology of the mammalian Krüppel-like family of transcription factors

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

1996 • 1,857 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

The Sp-family of transcription factors

1999 • 1,098 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

1994 • 766 citations

Klf4 is a transcription factor required for establishing the barrier function of the skin

1999 • 763 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

1993 • 703 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Identification and Characterization of a Gene Encoding a Gut-enriched Krüppel-like Factor Expressed during Growth Arrest

1996 • 647 citations

Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

1995 • 620 citations

DNA methylation: past, present and future directions

2000 • 609 citations

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

1999 • 607 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

1995 • 572 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Protein motifs 5. Zinc fingers.

1995 • 544 citations

Guidelines for Human Gene Nomenclature

2002 • 511 citations

Zinc fingers

1995 • 501 citations

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.

1993 • 464 citations

Zif268 protein–DNA complex refined at 1.6å: a model system for understanding zinc finger–DNA interactions

1996 • 416 citations

The primary structure of transcription factor TFIIIA has 12 consecutive repeats

1985 • 413 citations

A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

1986 • 409 citations

The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis

1997 • 365 citations

Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene.

1992 • 354 citations

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

1998 • 345 citations

The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter

2000 • 329 citations

Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators

1998 • 320 citations

A Gene for a Novel Zinc-finger Protein Expressed in Differentiated Epithelial Cells and Transiently in Certain Mesenchymal Cells

1996 • 311 citations

A SWI/SNF–Related Chromatin Remodeling Complex, E-RC1, Is Required for Tissue-Specific Transcriptional Regulation by EKLF In Vitro

1998 • 307 citations

Mammalian Krüppel-like transcription factors: more than just a pretty finger

1999 • 296 citations

Identification of a novel TGF-β-regulated gene encoding a putative zinc finger protein in human osteoblasts

1995 • 264 citations

Isolation of a Gene Encoding a Functional Zinc Finger Protein Homologous to Erythroid Krüppel-Like Factor: Identification of a New Multigene Family

1995 • 260 citations

Transcriptional Activation of Transforming Growth Factor β1 and Its Receptors by the Kruppel-like Factor Zf9/Core Promoter-binding Protein and Sp1

1998 • 250 citations

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis

1998 • 242 citations

Hepatocyte apoptosis: Is transforming growth factor-B1 the kiss of death? Oberhammer FA, Pavelka M, Sharma S, Tietenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 1992;89:5408–5412

1993 • 233 citations

Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.

1997 • 230 citations

Target Detection Assay (TDA): a versatile procedure to determine DNA blinding sites as demonstrated on SP1 protein

1990 • 229 citations

Isolation and Characterization of the cDNA Encoding BKLF/TEF-2, a Major CACCC-Box-Binding Protein in Erythroid Cells and Selected Other Cells

1996 • 229 citations

Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif

2000 • 215 citations

Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene Switching

1995 • 212 citations

The role of EKLF in human beta-globin gene competition.

1996 • 210 citations

TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.

1995 • 209 citations

cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2

1993 • 203 citations

Zinc Fingers in Caenorhabditis elegans : Finding Families and Probing Pathways

1998 • 200 citations

Molecular Cloning and Characterization of TIEG2Reveals a New Subfamily of Transforming Growth Factor-β-inducible Sp1-like Zinc Finger-encoding Genes Involved in the Regulation of Cell Growth

1998 • 190 citations

Expression of early growth response genes in human prostate cancer.

1998 • 184 citations

Human EZF, a Krüppel-like Zinc Finger Protein, Is Expressed in Vascular Endothelial Cells and Contains Transcriptional Activation and Repression Domains

1998 • 184 citations

Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factor

1998 • 181 citations

Hepatic stellate cells

1998 • 177 citations

A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells

1999 • 161 citations

Human Kruppel-like Factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription

2000 • 160 citations

The transforming growth factor ?1-inducible transcription factor, TIEG1, mediates apoptosis through oxidative stress

1999 • 157 citations

A Novel Human Zinc Finger Protein That Interacts with the Core Promoter Element of a TATA Box-less Gene

1997 • 141 citations

Loss of LKLF function results in embryonic lethality in mice.

1998 • 139 citations

BTEB2, a Krüppel-Like Transcription Factor, Regulates Expression of the SMemb/Nonmuscle Myosin Heavy Chain B (SMemb/NMHC-B) Gene

1999 • 138 citations

Expression of the Transcription Factor Lung Krüppel-Like Factor Is Regulated by Cytokines and Correlates with Survival of Memory T Cells In Vitro and In Vivo

1999 • 135 citations

Two Potent Nuclear Localization Signals in the Gut-enriched Krüppel-like Factor Define a Subfamily of Closely Related Krüppel Proteins

1997 • 131 citations

High-resolution localization of 69 potential human zinc finger protein genes: A number are clustered

1992 • 131 citations

The Gut-enriched Krüppel-like Factor Suppresses the Activity of the CYP1A1 Promoter in an Sp1-dependent Fashion

1998 • 129 citations

Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction

2000 • 125 citations

The Erythroid Krüppel-Like Factor Transactivation Domain is a Critical Component for Cell-Specific Inducibility of a β-Globin Promoter

1995 • 124 citations

Basic Transcription Element-binding Protein (BTEB) Is a Thyroid Hormone-regulated Gene in the Developing Central Nervous System

1999 • 124 citations

The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1

2000 • 122 citations

Three Conserved Transcriptional Repressor Domains Are a Defining Feature of the TIEG Subfamily of Sp1-like Zinc Finger Proteins

1999 • 119 citations

Cloning the cDNA for a New Human Zinc Finger Protein Defines a Group of Closely Related Krüppel-like Transcription Factors

1998 • 119 citations

Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines.

1996 • 118 citations

Transcriptional Regulation of the CLC-K1 Promoter by myc-Associated Zinc Finger Protein and Kidney-Enriched Krüppel-Like Factor, a Novel Zinc Finger Repressor

2000 • 117 citations

Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II

1991 • 116 citations

Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-β1 in vascular endothelial cells

2000 • 115 citations

Expression of the gut‐enriched Krüppel‐like factor gene during development and intestinal tumorigenesis

1997 • 114 citations

Lung Kruppel-like Factor, a Zinc Finger Transcription Factor, Is Essential for Normal Lung Development

1999 • 113 citations

Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny

1996 • 110 citations

RFLAT-1

1999 • 106 citations

Regulation of CYP1A1 expression

1992 • 104 citations

NOMENCLATURE

1997 • 103 citations

Decreased expression of the gut‐enriched Krüppel‐like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients

2000 • 101 citations

A zinc‐finger transcription factor induced by TGF‐β promotes apoptotic cell death in epithelial Mv1Lu cells

1999 • 100 citations

Transcriptional Activation of the Zinc Finger Transcription Factor BTEB2 Gene by Egr-1 Through Mitogen-Activated Protein Kinase Pathways in Vascular Smooth Muscle Cells

1999 • 99 citations

A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene.

1990 • 96 citations

Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation.

1995 • 92 citations

Transcriptional Regulation of the AP-2α Promoter by BTEB-1 and AP-2rep, a Novel wt-1/egr-Related Zinc Finger Repressor

1999 • 92 citations

Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)

1996 • 88 citations

Tissue, cell type, and breast cancer stage-specific expression of a TGF-β inducible early transcription factor gene

1998 • 86 citations

Transactivation of the Human Keratin 4 and Epstein-Barr Virus ED-L2 Promoters by Gut-enriched Krüppel-like Factor

1998 • 85 citations

The DNA Binding Protein BTEB Mediates Acetaldehyde-Induced, Jun N-Terminal Kinase-Dependent αI(I) Collagen Gene Expression in Rat Hepatic Stellate Cells

2000 • 83 citations

Developmental expression of the mouse gene coding for the kr�ppel-like transcription factor KLF5

2000 • 83 citations

TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth

2000 • 80 citations

Estrogen Regulation of a Transforming Growth Factor-β Inducible Early Gene That Inhibits Deoxyribonucleic Acid Synthesis in Human Osteoblasts*

1998 • 77 citations

Discrimination Among Potential Activators of the β-Globin CACCC Element by Correlation of Binding and Transcriptional Properties

1993 • 74 citations

Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)

1999 • 73 citations

Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue of AML1-Deficient Embryonic Stem Cells by Using a Knock-in Strategy

2000 • 68 citations

Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors

1999 • 68 citations

Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter

1999 • 68 citations

The Krüppel‐like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact

2000 • 68 citations

Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions.

1996 • 68 citations

Up‐regulation of gut‐enriched krüppel‐like factor by interferon‐γ in human colon carcinoma cells

2000 • 65 citations

Erythroid Kruppel like factor: from fishing expedition to gourmet meal

1999 • 64 citations

Regulation of Erythroid Krüppel-like Factor (EKLF) Transcriptional Activity by Phosphorylation of a Protein Kinase Casein Kinase II Site within Its Interaction Domain

1998 • 63 citations

Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line

1998 • 59 citations

GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk

1999 • 55 citations

Fetal expression of a human Aγ globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

2000 • 55 citations

Cell-specific Transcription of Leukotriene C4Synthase Involves a Kruppel-like Transcription Factor and Sp1

2000 • 53 citations

Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation

1995 • 52 citations

Comparison of DNA-Binding Properties between BTEB and Sp11

1993 • 51 citations

Genomic Structure and DNA Binding Properties of the Human Zinc Finger Transcriptional Repressor AP-2rep (KLF12)

2000 • 48 citations

cDNA Isolation, Genomic Structure, Regulation, and Chromosomal Localization of Human Lung Kruppel-like Factor

1999 • 42 citations

Hepatic Stellate Cells

2023 • 41 citations

Isolation and Initial Characterization of GBF, a Novel DNA-Binding Zinc Finger Protein That Binds to the GC-Rich Binding Sites of the HIV-1 Promoter

1998 • 41 citations

Trans-Activation Functions of the Sp-Related Nuclear Factor, Basic Transcription Element-Binding Protein, and Progesterone Receptor in Endometrial Epithelial Cells*

1999 • 38 citations

Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties.

1993 • 38 citations

Eukaryotic Transcription Factors: Identification, Characterization and Functions

1998 • 37 citations

Characterization of the mouse TGFβ-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts

1998 • 34 citations

Erythroid Krüppel-like factor is recruited to the CACCC box in the β-globin promoter but not to the CACCC box in the γ-globin promoter: The role of the neighboring promoter elements

2000 • 33 citations

Analysis of Functional Domains of a GC Box-Binding Protein, BTEB1

1995 • 32 citations

Estrogen Regulation of a Transforming Growth Factor- Inducible Early Gene That Inhibits Deoxyribonucleic Acid Synthesis in Human Osteoblasts

1998 • 24 citations

Cell-type Expression, Immunolocalization, and Deoxyribonucleic Acid-binding Activity of Basic Transcription Element Binding Transcription Factor, an Sp-related Family Member, in Porcine Endometrium of Pregnancy1

1997 • 23 citations

cDNA cloning and expression analysis of mouse zf9, a Krüppel-like transcription factor gene that is induced by adipogenic hormonal stimulation in 3T3-L1 cells

1999 • 23 citations

Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein

1993 • 21 citations

The Role of Sp Family Members, Basic Krupple-Like Factor, and E Box Factors in the Basal and IFN-γ Regulated Expression of the Human Complement C4 Promoter

2000 • 19 citations

A Novel cis-Acting DNA Element Required for a High Level of Inducible Expression of the Rat P-450c Gene

1990 • 17 citations

Trans-Activation Functions of the Sp-Related Nuclear Factor, Basic Transcription Element-Binding Protein, and Progesterone Receptor in Endometrial Epithelial Cells

1999 • 15 citations