The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Regulation ofp53downstream genes

1998 • 777 citations

Klf4 is a transcription factor required for establishing the barrier function of the skin

1999 • 763 citations

The p53 Network

1998 • 731 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

1999 • 665 citations

Identification and Characterization of a Gene Encoding a Gut-enriched Krüppel-like Factor Expressed during Growth Arrest

1996 • 647 citations

Signaling to p53

1998 • 636 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

1997 • 509 citations

BRCA1 physically associates with p53 and stimulates its transcriptional activity

1998 • 484 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects

1999 • 394 citations

Progesterone Regulates Transcription of the p21 Cyclindependent Kinase Inhibitor Gene through Sp1 and CBP/p300

1998 • 352 citations

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1998 • 348 citations

A Gene for a Novel Zinc-finger Protein Expressed in Differentiated Epithelial Cells and Transiently in Certain Mesenchymal Cells

1996 • 311 citations

Mammalian Krüppel-like transcription factors: more than just a pretty finger

1999 • 296 citations

Histone Deacetylase Inhibitor Activates the WAF1/Cip1 Gene Promoter through the Sp1 Sites

1997 • 291 citations

Analysis of the mammalian gadd45 gene and its response to DNA damage.

1993 • 231 citations

Chromatin Remodeling and the Control of Gene Expression

1997 • 224 citations

Essential role for p53-mediated transcription in E1A-induced apoptosis.

1995 • 219 citations

The Role of the Transcription Factor Sp1 in Regulating the Expression of the WAF1/CIP1 Gene in U937 Leukemic Cells

1996 • 215 citations

The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation.

1997 • 209 citations

Human EZF, a Krüppel-like Zinc Finger Protein, Is Expressed in Vascular Endothelial Cells and Contains Transcriptional Activation and Repression Domains

1998 • 184 citations

Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factor

1998 • 181 citations

Factors associated with the mammalian RNA polymerase II holoenzyme

1998 • 167 citations

Inhibition of the 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Pathway Induces p53-independent Transcriptional Regulation of p21 in Human Prostate Carcinoma Cells

1998 • 161 citations

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding

1998 • 152 citations

Immunohistology of the Antigenic Pattern of a Continuous Cell Line From a Human Colon Tumor

1975 • 142 citations

p21^WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA

1998 • 138 citations

Involvement of the Sp3 Transcription Factor in Induction of p21 in Keratinocyte Differentiation

1997 • 134 citations

Two Potent Nuclear Localization Signals in the Gut-enriched Krüppel-like Factor Define a Subfamily of Closely Related Krüppel Proteins

1997 • 131 citations

The Gut-enriched Krüppel-like Factor Suppresses the Activity of the CYP1A1 Promoter in an Sp1-dependent Fashion

1998 • 129 citations

Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction

2000 • 125 citations

p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes.

1993 • 120 citations

p21 (WAF1/CIP1) Expression Is Induced in Newly Nondividing Cells in Diverse Epithelia and during Differentiation of the Caco-2 Intestinal Cell Line

1996 • 119 citations

Expression of the gut‐enriched Krüppel‐like factor gene during development and intestinal tumorigenesis

1997 • 114 citations

p300 and CBP as transcriptional regulators and targets of oncogenic events.

1996 • 110 citations

Sp1, but not Sp3, functions to mediate promoter activation by TGF- through canonical Sp1 binding sites

1998 • 99 citations

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

1996 • 89 citations

Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

1998 • 86 citations

Transactivation of the Human Keratin 4 and Epstein-Barr Virus ED-L2 Promoters by Gut-enriched Krüppel-like Factor

1998 • 85 citations

Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)

1999 • 73 citations

Viral oncoprotein binding to pRB, p107, p130, and p300

1995 • 64 citations

GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk

1999 • 55 citations

Histone Acetyltransferase Complexes and Their Link to Transcription

1999 • 49 citations

Growth Arrest of Melanoma Cells Is Differentially Regulated by Contact Inhibition and Serum Deprivation

1999 • 37 citations