Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.

1995 • 1,354 citations

Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency

1997 • 1,157 citations

Osteoporosis in Men

2008 • 920 citations

Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors

1988 • 908 citations

Human bone cellsin vitro

1985 • 696 citations

The Human Androgen Receptor: Complementary Deoxyribonucleic Acid Cloning, Sequence Analysis and Gene Expression in Prostate

1988 • 575 citations

Long-Term Effect of Testosterone Therapy on Bone Mineral Density in Hypogonadal Men

1997 • 531 citations

Development and characterization of a conditionally immortalized human fetal osteoblastic cell line

1995 • 485 citations

Androgens in Men — Uses and Abuses

1996 • 470 citations

Identification of androgen receptors in normal human osteoblast-like cells.

1989 • 464 citations

Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.

1995 • 440 citations

Osteopenia in Men with a History of Delayed Puberty

1992 • 433 citations

ANDROGENS DIRECTLY STIMULATE PROLIFERATION OF BONE CELLS IN VITRO

1989 • 404 citations

Osteoporosis in Men

1995 • 326 citations

Identification of a novel TGF-β-regulated gene encoding a putative zinc finger protein in human osteoblasts

1995 • 264 citations

Short- and long-term effects of estrogen and synthetic anabolic hormone in postmenopausal osteoporosis

1972 • 227 citations

Gonadal and Adrenal Androgens Are Potent Regulators of Human Bone Cell Metabolism In Vitro

1997 • 197 citations

Importance of Gonadal Steroids to Bone Mass in Men with Hyperprolactinemic Hypogonadism

1989 • 193 citations

Effect of age on bone density and bone turnover in men

1995 • 179 citations

Studies of the Mechanism by which Androgens Enhance Mitogenesis and Differentiation in Bone Cells*

1990 • 170 citations

Effect of testosterone therapy on bone formation in an osteoporotic hypogonadal male

1978 • 163 citations

Localization of 1,25-(OH)2D3-responsive alkaline phosphatase in osteoblast-like cells (ROS 17/2.8, MG 63, and MC 3T3) and growth cartilage cells in culture

1989 • 150 citations

Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.

1993 • 148 citations

High-Affinity Androgen Binding and Androgenic Regulation of α1(I)-Procollagen and Transforming Growth Factor-β Steady State Messenger Ribonucleic Acid Levels in Human Osteoblast-Like Osteosarcoma Cells*

1991 • 145 citations

Androgen receptors in osteoblast-like cell lines

1991 • 140 citations

Direct and sex-specific stimulation by sex steroids of creatine kinase activity and DNA synthesis in rat bone.

1989 • 138 citations

Androgens and bone

1995 • 138 citations

Androgen-Induced Inhibition of Proliferation in Human Breast Cancer MCF7 Cells Transfected with Androgen Receptor*

1997 • 126 citations

Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations

1997 • 125 citations

Estrogen Regulation of Human Osteoblastic Cell Proliferation and Differentiation*

1997 • 122 citations

Sources of Variability in Bone Mineral Density Measurements: Implications for Study Design and Analysis of Bone Loss

1997 • 108 citations

Human bone cell enzyme expression and cellular heterogeneity: Correlation of alkaline phosphatase enzyme activity with cell cycle

1990 • 96 citations

Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells

1994 • 85 citations

Serum testosterone and its relation to bone mineral density and body composition in normal males

1995 • 84 citations

Effects of androgens on parathyroid hormone and interleukin-1-stimulated prostaglandin production in cultured neonatal mouse calvariae

1990 • 82 citations

Characteristics of steroid hormone receptors in cultured MC3T3-E1 osteoblastic cells and effect of steroid hormones on cell proliferation

1992 • 82 citations

Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor.

1992 • 72 citations

Androgens Directly Stimulate Mineralization and Increase Androgen Receptors in Human Osteoblast-like Osteosarcoma Cells

1994 • 68 citations

Regulation of c-fos expression and TGF-β production by gonadal and adrenal androgens in normal human osteoblastic cells

1995 • 68 citations

Human osteoblast-like cells contain specific, saturable, high-affinity glucocorticoid, androgen, estrogen, and 1 alpha,25-dihydroxycholecalciferol receptors.

1994 • 67 citations

Estrogen response in the hFOB 1.19 human fetal osteoblastic cell line stably transfected with the human estrogen receptor gene

1995 • 66 citations

Effect of sex steroids on bone collagen synthesis in vitro

1978 • 62 citations

The receptor, metabolism and effects of androgen in osteoblastic MC3T3-E1 cells

1994 • 60 citations

Animal Models of Nonthyroidal Disease*

1985 • 58 citations

Nuclear RNA polymerase activities and poly(A)-containing mRNA accumulation in cultured AKR mouse embryo cells stimulated to proliferate

1977 • 58 citations

Interaction of androgen and 1,25-dihydroxyvitamin D3: Effects on normal rat bone cells

1992 • 57 citations

Human Osteoblast‐Like Cells Contain Specific, Saturable, High‐Affinity Glucocorticoid, Androgen, Estrogen, and 1α,—Dihydroxycholecalciferol Receptors

1994 • 52 citations

Evidence for a novel mechanism of androgen resistance in the human prostate cancer cell line, PC-3

1995 • 52 citations

Stable transfection of the oestrogen receptor gene into a human osteosarcoma cell line

1989 • 51 citations

Perspectives: Human osteoblastic cells: A potential tool to assess the etiology of pathologic bone formation

1994 • 50 citations

Subcellular location of androgen receptor in rat prostate, seminal vesicle and human osteosarcoma MG-63 cells

1992 • 46 citations

Sex-specific response of bone cells to gonadal steroids: modulation in perinatally androgenized females and in testicular feminized male rats

1993 • 39 citations

Effects of androgens on subpopulations of the human osteosarcoma cell line SaOS2

1996 • 36 citations

Overexpression of estrogen receptor in HTB 96 human osteosarcoma cells results in estrogen-induced growth inhibition and receptor cross talk

1994 • 31 citations

Development and characterization of a conditionally immortalized human osteoblastic cell line stably transfected with the human androgen receptor gene

1997 • 27 citations

Absence of androgen-mediated transcriptional effects in osteoblastic cells despite presence of androgen receptors

1997 • 15 citations