Immunotherapy of murine prostate cancer using whole tumour cells killed ex vivo by cytosine deaminase/5‐fluorocytosine suicide‐gene therapy

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells

2000 • 627 citations

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.

1992 • 511 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial

2004 • 441 citations

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

1994 • 420 citations

Establishment and characterization of seven dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers

1986 • 412 citations

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1994 • 224 citations

Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

1997 • 192 citations

The allogeneic response and tumor immunity

2001 • 103 citations

Immunotherapy of advanced prostate cancer: a phase I/II trial using Mycobacterium vaccae (SRL172)

1998 • 86 citations

Transplantable Metastasizing Prostate Adenocarcinomas in Rats<xref ref-type="fn" rid="fn2">2</xref>

1975 • 82 citations

Ex-vivo gene therapy using cytokine-transduced tumor vaccines: molecular and clinical pharmacology.

1998 • 80 citations

Apoptosis induced at different dose rates: implication for the shoulder region of cell survival curves

1994 • 53 citations

The lobund-wistar rat model of prostate cancer

1992 • 51 citations

Cytosine Deaminase/5-Fluorocytosine-Based Vaccination Against Liver Tumors: Evidence of Distant Bystander Effect

1999 • 46 citations

Apoptosis Induction With 5-Fluorocytosine/Cytosine Deaminase gene Therapy for Human Malignant Glioma Cells Mediated by Adenovirus

2004 • 39 citations

Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity

2000 • 37 citations

Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes.

1996 • 30 citations

Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma

2000 • 27 citations

The Immune Response Elicited by Mammary Adenocarcinoma Cells Transduced with Interferon-γand Cytosine Deaminase Genes Cures Lung Metastases by Parental Cells

1998 • 26 citations

The Dunning R3327 Prostate Adenocarcinoma in the Fischer-Copenhagen F1 Rat: A Useful Model for Immunological Studies

1977 • 26 citations

Coxsackie B and adenovirus receptor, integrin and major histocompatibility complex class I expression in human prostate cancer cell lines: implications for gene therapy strategies

2003 • 26 citations

Induction of protective immunity against syngeneic rat cancer cells by expression of the cytosine deaminase suicide gene

2000 • 22 citations

Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques

2001 • 21 citations

Role of Antigen-Presenting Cells in Long-Term Antitumor Response Based on Tumor-Derived Apoptotic Body Vaccination

1999 • 19 citations

Cell death associated with genetic prodrug activation therapy of colorectal cancer

2001 • 19 citations

Advances in prostate cancer immunotherapy

2002 • 15 citations

Heated tumour cells of autologous and allogeneic origin elicit anti-tumour immunity

2004 • 14 citations

Viral oncolysates in cancer treatment: immunological mechanisms of action (review).

1989 • 14 citations

Relationship between Pulmonary Embolism, Airway Obstruction and Hypersensitivity of the Airways in Dogs

1977 • 11 citations

Regression of experimental liver tumor after distant intra-hepatic injection of cytosine deaminase-expressing tumor cells and 5-fluorocytosine treatment.

2000 • 10 citations

Potential benefits of combining cytosine deaminase/5‐fluorocytosine gene therapy and irradiation for prostate cancer: Experimental study

2002 • 10 citations

Induction of protective immunity against syngeneic rat cancer cells by expression of the cytosine deaminase suicide gene

2000 • 7 citations

Augmentation of antitumor effect of adenovirus-mediated CD suicide gene therapy by cotransfer of interleukin 2 gene in melanoma-bearing mice.

1999 • 4 citations

Augmentation of antitumor effect of adenovirus mediated CD suicide gene therapy by cotransfer of interleukin 2 gene in melanoma bearing mice

1999 • 1 citations