Potential benefits of combining cytosine deaminase/5‐fluorocytosine gene therapy and irradiation for prostate cancer: Experimental study

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1994 • 224 citations

Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line.

1995 • 171 citations

In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.

1997 • 170 citations

Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector.

2000 • 164 citations

Radiosensitizing Nucleosides

1996 • 139 citations

Osteocalcin-directed gene therapy for prostate-cancer bone metastasis

2000 • 122 citations

A metastatic and androgen-sensitive human prostate cancer model using intraprostatic inoculation of LNCaP cells in SCID mice.

1997 • 105 citations

Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts.

1997 • 94 citations

Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine.

1998 • 92 citations

Growth of an androgen‐sensitive human prostate cancer cell line, LNCaP, in nude mice

1993 • 89 citations

Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine.

1994 • 88 citations

Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo.

1997 • 86 citations

Regional ‘pro-drug’ gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma

1998 • 74 citations

In VivoAdenoviral-Mediated Gene Transfer in the Treatment of Pancreatic Cancer

1997 • 61 citations

Selection of radioimmunoconjugates for the therapy of well-established or micrometastatic colon carcinoma

1997 • 59 citations

Enhanced antitumor activity of combination radioimmunotherapy (131I-labeled monoclonal antibody A33) with chemotherapy (fluorouracil).

1997 • 46 citations

Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models

2000 • 46 citations

Increased tumor tissue pressure in association with the growth of rat tumors.

1986 • 45 citations

CYTOTOXICITY OF ADENOVIRAL-MEDIATED CYTOSINE DEAMINASE PLUS 5-FLUOROCYTOSINE GENE THERAPY IS SUPERIOR TO THYMIDINE KINASE PLUS ACYCLOVIR IN A HUMAN RENAL CELL CARCINOMA MODEL

1999 • 31 citations

ADENOVIRUS MEDIATED CYTOSINE DEAMINASE GENE TRANSDUCTION AND 5-FLUOROCYTOSINE THERAPY SENSITIZES MOUSE PROSTATE CANCER CELLS TO IRRADIATION

2000 • 24 citations

Radioimmunodetection of cancer with the use of indium-111-labeled monoclonal antibodies.

1987 • 24 citations

Efficacy, toxicity and mode of interaction of combination radioimmunotherapy with 5-fluorouracil in colon cancer xenografts

1999 • 21 citations

Development of monoclonal antibody imaging of metastatic prostatic carcinoma

1989 • 20 citations

Radioimmunodetection of prostatic cancer with 125I-labelled antibody against prostatic specific antigen.

1988 • 7 citations

Enhanced tumorigenic and metastatic potential of an androgen-sensitive human prostate cancer cell line, LNCaP, by intratesticular inoculation in SCID mice

1997 • 4 citations

Factors Contributing to Imaging of Xenografts Using Anti-Placental Alkaline Phosphatase Monoclonal Antibody

1997 • 4 citations