The Immune Response Elicited by Mammary Adenocarcinoma Cells Transduced with Interferon-γand Cytosine Deaminase Genes Cures Lung Metastases by Parental Cells

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

1994 • 308 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1994 • 224 citations

TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma

1983 • 223 citations

Gene Transfer in Regenerating Muscle

1994 • 181 citations

Cytokines, tumour-cell death and immunogenicity: a question of choice

1997 • 168 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

CD4 T cells inhibit in vivo the CD8‐mediated immune response against murine colon carcinoma cells transduced with interleukin‐12 genes

1995 • 125 citations

5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory.

1995 • 109 citations

Inhibition of tumor growth and enhancement of metastasis after transfection of the γ‐interferon gene

1993 • 97 citations

Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.

1994 • 97 citations

IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-gamma-producing TS/A cells.

1994 • 87 citations

Construction of a fusion gene that confers resistance against hygromycin B to mammalian cells in culture

1985 • 86 citations

Tumor cells cotransfected with interleukin‐7 and B7.1 genes induce CD25 and CD28 on tumor‐infiltrating T lymphocytes and are strong vaccines

1995 • 85 citations

The Thymidine Kinase/Ganciclovir-Mediated “Suicide” Effect Is Variable in Different Tumor Cells

1995 • 80 citations

Cure of Mice with Established Metastatic Friend Leukemia Cell Tumors by a Combined Therapy with Tumor Cells Expressing Both Interferon-α1 and Herpes Simplex Thymidine Kinase Followed by Ganciclovir

1996 • 35 citations

Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes.

1996 • 30 citations

Immunological and non-immunological influence ofH-2Kb gene transfection on the metastatic ability of B16 melanoma cells

1991 • 28 citations

Elimination of CD4+ T cells in mice bearing an advanced sarcoma augments the antitumor action of interleukin-2

1994 • 26 citations

Direct cell killing by suicide genes

1996 • 25 citations

Transduction of Genes Coding for a Histocompatibility (MHC) Antigen and for Its Physiological Inducer Interferon-γ in the Same Cell: Efficient MHC Expression and Inhibition of Tumor and Metastasis Growth

1995 • 22 citations