Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

2003 • 5,516 citations

J Neuropsychiatry Clin Neurosci

1992 • 3,756 citations

Publication bias in clinical research

1991 • 3,034 citations

Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

2004 • 2,021 citations

Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

2004 • 1,637 citations

Structural Magnetic Resonance Imaging of the Adolescent Brain

2004 • 1,562 citations

Structural and functional brain development and its relation to cognitive development

2000 • 1,475 citations

Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort

1994 • 1,326 citations

Problems of reporting genetic associations with complex outcomes

2003 • 1,221 citations

A Neural Basis for General Intelligence

2000 • 1,037 citations

Catechol O -methyltransferase val ¹⁵⁸ -met genotype and individual variation in the brain response to amphetamine

2003 • 900 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

Brain development, gender and IQ in children

1996 • 849 citations

The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers

2005 • 792 citations

The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes

2004 • 779 citations

Evidence for Early-Childhood, Pan-Developmental Impairment Specific to Schizophreniform Disorder

2002 • 777 citations

Cognitive Deficits in Unaffected First-Degree Relatives of Schizophrenia Patients: A Meta-analytic Review of Putative Endophenotypes

2005 • 681 citations

Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond

2006 • 667 citations

Meta-analysis of genetic association studies

2004 • 639 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

2002 • 613 citations

Functional frontalisation with age: mapping neurodevelopmental trajectories with fMRI

2000 • 543 citations

Epidemiological methods for studying genes and environmental factors in complex diseases

2001 • 473 citations

The endophenotype concept in psychiatric genetics

2006 • 454 citations

Genetic Theorizing and Schizophrenia

1973 • 415 citations

Intelligence in Schizophrenia: Meta-analysis of the Research

1984 • 407 citations

Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation

2000 • 402 citations

The Inheritance of Neuropsychological Dysfunction in Twins Discordant for Schizophrenia

2000 • 375 citations

Dopamine transporter immunoreactivity in monkey cerebral cortex: Regional, laminar, and ultrastructural localization

2001 • 355 citations

Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia

2002 • 327 citations

The molecular genetics of schizophrenia: new findings promise new insights

2003 • 327 citations

Schizophrenia: genes at last?

2005 • 310 citations

Catechol-O-Methyltransferase (COMT): A Gene Contributing to Sex Differences in Brain Function, and to Sexual Dimorphism in the Predisposition to Psychiatric Disorders

2007 • 297 citations

An Experimental Study of Catechol-O-Methyltransferase Val158Met Moderation of Δ-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition

2006 • 297 citations

Interaction of COMT Val^108/158 Met Genotype and Olanzapine Treatment on Prefrontal Cortical Function in Patients With Schizophrenia

2004 • 277 citations

Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case–control studies

2005 • 266 citations

Catechol-O-Methyltransferase (COMT) Genotypes and Working Memory: Associations with Differing Cognitive Operations

2005 • 260 citations

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis

2004 • 259 citations

Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis

2004 • 253 citations

Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene

2005 • 251 citations

Catechol O-Methyltransferase Val¹⁵⁸Met Polymorphism in Schizophrenia: Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility

2004 • 232 citations

Impaired attention as an endophenotype for molecular genetic studies of schizophrenia

2001 • 227 citations

Additive Effects of Genetic Variation in Dopamine Regulating Genes on Working Memory Cortical Activity in Human Brain

2006 • 224 citations

Obstacles and opportunities in meta-analysis of genetic association studies

2005 • 199 citations

Catechol-o-Methyltransferase Enzyme Activity and Protein Expression in Human Prefrontal Cortex across the Postnatal Lifespan

2006 • 194 citations

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

2005 • 194 citations

Dopamine and Cognitive Control: The Influence of Spontaneous Eyeblink Rate and Dopamine Gene Polymorphisms on Perseveration and Distractibility.

2005 • 191 citations

Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects

2007 • 187 citations

New Evidence of Association Between COMT Gene and Prefrontal Neurocognitive Function in Healthy Individuals From Sibling Pairs Discordant for Psychosis

2004 • 177 citations

The met158 allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case–control study and meta-analysis

2007 • 168 citations

COMT Gene Polymorphism Is Associated with Declarative Memory in Adulthood and Old Age

2004 • 149 citations

Variation in catechol-o-methyltransferase val158 met genotype associated with schizotypy but not cognition: A population study in 543 young men

2004 • 143 citations

Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females

2003 • 139 citations

Catechol O-Methyltransferase (COMT) mRNA Expression in the Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

2003 • 135 citations

Gender-Specific Effects of the Catechol- O -Methyltransferase Val ^108/158 Met Polymorphism on Cognitive Function in Children

2007 • 134 citations

COMT genetic variation confers risk for psychotic and affective disorders: a case control study

2005 • 132 citations

Genetic Variation in Catechol-O-Methyltransferase: Effects on Working Memory in Schizophrenic Patients, Their Siblings, and Healthy Controls

2007 • 130 citations

Intellectual Decline in Schizophrenia: Evidence from a Prospective Birth Cohort 28 Year Follow-up Study

2006 • 129 citations

Planning ability in Parkinson's disease is influenced by the COMT val¹⁵⁸met polymorphism

2004 • 119 citations

Relationship of Catechol-O-Methyltransferase Variants to Brain Structure and Function in a Population at High Risk of Psychosis

2006 • 118 citations

Association of COMT Val158Met Genotype With Executive Functioning Following Traumatic Brain Injury

2005 • 110 citations

DTNBP1 genotype influences cognitive decline in schizophrenia

2006 • 109 citations

COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia

2006 • 101 citations

Establishment of genetic associations for complex diseases is independent of early study findings

2004 • 94 citations

Longitudinal and cross-sectional twin data on cognitive abilities in adulthood: The Swedish Adoption/Twin Study of Aging.

1998 • 93 citations

COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance

2007 • 90 citations

The functional COMT polymorphism, Val158Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds

2005 • 89 citations

Genetic linkage and association between chromosome 1q and working memory function in schizophrenia

2002 • 88 citations

The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD

2005 • 87 citations

COMT genotype and cognitive ability: A longitudinal aging study

2007 • 76 citations

Effect of COMT Val¹⁵⁸Met Polymorphism on the Continuous Performance Test, Identical Pairs Version: Tuning Rather Than Improving Performance

2005 • 76 citations

Effect of Schizotypy on Cognitive Performance and Its Tuning by COMT val158 Met Genotype Variations in a Large Population of Young Men

2006 • 73 citations

COMT genotype, gender and cognition in community-dwelling, older adults

2006 • 71 citations

Longitudinal and cross-sectional twin data on cognitive abilities in adulthood: The Swedish Adoption/Twin Study of Aging.

1998 • 71 citations

Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance

2006 • 64 citations

Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

2006 • 62 citations

Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients

2005 • 61 citations

Catechol-O-Methyltransferase (COMT) Val 108/158 Metpolymorphism does not modulate executive function in children with ADHD

2004 • 61 citations

Catechol-O-Methyltransferase Val<sup>158</sup>Met Polymorphism in Schizophrenia: Associations with Cognitive and Motor Impairment

2005 • 58 citations

Performance on the Wisconsin Card Sorting Test in schizophrenia and genes of dopaminergic inactivation (COMT, DAT, NET)

2006 • 51 citations

Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups

2006 • 47 citations

BDNF and COMT Polymorphisms: Relation to Memory Phenotypes in Young Adults With Childhood-Onset Mood Disorder

2004 • 45 citations

Lack of influence of COMT and NET genes variants on executive functions in schizophrenic and bipolar patients, their first‐degree relatives and controls

2006 • 45 citations

COMT val158Met and executive control: A test of the benefit of specific deficits to translational research.

2007 • 45 citations

Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives

2006 • 39 citations

The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia

2007 • 11 citations