Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

Co-Planar Stereotaxic Atlas of the Human Brain

1988 • 11,912 citations

Co-planar stereotaxic atlas of the human brain

1989 • 7,557 citations

Validity of the Trail Making Test as an Indicator of Organic Brain Damage

1958 • 7,146 citations

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

2003 • 5,516 citations

Working Memory

1992 • 4,636 citations

Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies

1991 • 2,314 citations

Rapid Automated Algorithm for Aligning and Reslicing PET Images

1992 • 1,958 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

Wisconsin Card Sorting Test manual

1993 • 1,489 citations

The Comprehensive Assessment of Symptoms and History (CASH)

1992 • 1,292 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

High Rates of Schizophrenia in Adults With Velo-Cardio-Facial Syndrome

1999 • 1,013 citations

Schizophrenics Show Spatial Working Memory Deficits

1992 • 953 citations

Functional activation of the human frontal cortex during the performance of verbal working memory tasks.

1993 • 905 citations

Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis.

1983 • 837 citations

Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia

2002 • 824 citations

Physiological Dysfunction of the Dorsolateral Prefrontal Cortex in Schizophrenia Revisited

2000 • 811 citations

Prefrontal neurons and the genetics of schizophrenia

2001 • 738 citations

A Highly Significant Association between a COMT Haplotype and Schizophrenia

2002 • 701 citations

The Effects of Atypical Antipsychotic Drugs on Neurocognitive Impairment in Schizophrenia: A Review and Meta-analysis

1999 • 698 citations

Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings

2003 • 682 citations

The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task

1994 • 663 citations

Dopamine Uptake through the Norepinephrine Transporter in Brain Regions with Low Levels of the Dopamine Transporter: Evidence from Knock-Out Mouse Lines

2002 • 661 citations

Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients With Schizophrenia

2001 • 616 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

2002 • 613 citations

Executive Subprocesses in Working Memory

2003 • 591 citations

Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance

2000 • 498 citations

A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges

1996 • 462 citations

Distribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390

1991 • 396 citations

Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI

1999 • 390 citations

Spatial Working Memory Deficits in the Relatives of Schizophrenic Patients

1995 • 375 citations

The Inheritance of Neuropsychological Dysfunction in Twins Discordant for Schizophrenia

2000 • 375 citations

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles

1999 • 371 citations

Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys

1981 • 352 citations

Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain

2000 • 350 citations

3‐Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple Two Pool Model

1994 • 349 citations

Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies

2003 • 348 citations

Assessing the molecular genetics of attention networks.

2002 • 340 citations

Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia

2002 • 327 citations

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia

2002 • 322 citations

Automatic Atlas-Based Volume Estimation of Human Brain Regions from MR Images

1996 • 320 citations

The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific

1987 • 319 citations

Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey

1994 • 313 citations

Schizophrenia: the fundamental questions

2000 • 308 citations

Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia

1999 • 296 citations

Longitudinal Study of Cognitive Function in First-Episode and Recent-Onset Schizophrenia

1999 • 293 citations

Association Between Age-Related Decline in Brain Dopamine Activity and Impairment in Frontal and Cingulate Metabolism

2000 • 282 citations

Psychopathology and the Brain

1991 • 279 citations

Verbal Working Memory Impairment in Schizophrenia Patients and Their First-Degree Relatives: Evidence From the Digit Span Task

2000 • 279 citations

Image processing for the study of brain structure and function: problems and programs

1992 • 265 citations

Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design

2001 • 258 citations

D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain

2001 • 254 citations

Childhood Cognitive Functioning in Schizophrenia Patients and Their Unaffected Siblings: A Prospective Cohort Study

2000 • 250 citations

Improving Tissue Classification in MRI: A Three-Dimensional Multispectral Discriminant Analysis Method with Automated Training Class Selection

1999 • 247 citations

Catechol O-Methyltransferase Val¹⁵⁸Met Polymorphism in Schizophrenia: Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility

2004 • 232 citations

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior

1997 • 222 citations

Genetic structure of spatial and verbal working memory.

2001 • 217 citations

Age-related changes in human D1 dopamine receptors measured by positron emission tomography

1991 • 214 citations

Learning and memory in monozygotic twins discordant for schizophrenia

1993 • 212 citations

Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging

1998 • 194 citations

Association Between Catechol O-Methyltransferase Genotype and Violence in Schizophrenia and Schizoaffective Disorder

1998 • 192 citations

Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging

1993 • 189 citations

Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease

1996 • 185 citations

Region‐specific distribution of catecholamine afferents in primate cerebral cortex: A fluorescence histochemical analysis

1984 • 185 citations

Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients

1996 • 183 citations

Measurement of Brain Structures with Artificial Neural Networks: Two- and Three-dimensional Applications

1999 • 181 citations

Brain catecholamine metabolism in catechol‐O‐methyltransferase (COMT)‐deficient mice

2002 • 178 citations

Association of the G1947A COMT (Val108/158Met) gene polymorphism with prefrontal P300 during information processing

2003 • 173 citations

Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity

1999 • 167 citations

Working Memory in Schizophrenia: Transient "Online" Storage Versus Executive Functioning

2001 • 154 citations

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity

1996 • 149 citations

The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra?

2003 • 145 citations

Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females

2003 • 139 citations

Muscarinic and dopaminergic receptors in the aging human brain

1987 • 130 citations

Preferential transmission of the high activity allele of COMT in schizophrenia

1996 • 127 citations

Characterization of Extracellular Dopamine Clearance in the Medial Prefrontal Cortex: Role of Monoamine Uptake and Monoamine Oxidase Inhibition

2001 • 124 citations

Effects of neuroleptic medications on the cognition of patients with schizophrenia: a review of recent studies.

1996 • 121 citations

Suicidal behavior in patients with schizophrenia is related to COMT polymorphism

2000 • 114 citations

Identification of Sequence Variants and Analysis of the Role of the Catechol-O-Methyl-Transferase Gene in Schizophrenia Susceptibility

1998 • 109 citations

Catechol-O-methyltransferase polymorphisms and schizophrenia

1997 • 106 citations

The effect of aging on the D1 dopamine receptors in human frontal cortex

1990 • 94 citations

Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics

1998 • 94 citations

Tests for Comparing Images Based on Randomization and Permutation Methods

1996 • 93 citations

Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype

2001 • 92 citations

Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis

2002 • 92 citations

Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia

2002 • 89 citations

Dimensions of working memory dysfunction in schizophrenia

2003 • 89 citations

Screening for 22q11 deletions in a schizophrenia population

2001 • 85 citations

Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients

2003 • 79 citations

Association Analysis of a Functional Catechol-O-Methyltransferase Gene Polymorphism in Schizophrenic Patients in Taiwan

2001 • 79 citations

Lack of association of functional cathechol-O-methyltransferase gene polymorphism in schizophrenia

1997 • 75 citations

Association between Val^108/158 met polymorphism of the COMT gene and schizophrenia

2003 • 75 citations

Visual Perception and Working Memory in Schizotypal Personality Disorder

2000 • 72 citations

Relationship between catechol‐O‐methyltransferase polymorphism and treatment‐resistant schizophrenia

2003 • 71 citations

Neuropsychological impairments in neuroleptic-responder vs. -nonresponder schizophrenic patients and healthy volunteers

2002 • 69 citations

A Working Memory

2002 • 67 citations

Catechol-O -methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis

2001 • 66 citations

Spatial working memory deficits in schizophrenia patients and their first degree relatives from Palau, Micronesia

2002 • 64 citations

Techniques for measuring sulcal/gyral patterns in the brain as visualized through magnetic resonance scanning: BRAINPLOT and BRAINMAP.

1994 • 54 citations

Linkage disequilibrium on theCOMT gene in French schizophrenics and controls

1999 • 52 citations

Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia

2001 • 49 citations

Indicators of Liability to Schizophrenia: Perspectives From Genetic Epidemiology

1994 • 48 citations

Systematic Mutation Analysis of the Catechol O-Methyltransferase Gene as a Candidate Gene for Schizophrenia

1999 • 48 citations

NOTCH4 and the frontal lobe in schizophrenia

2003 • 42 citations

Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia

2002 • 42 citations

Lack of evidence for association between the COMT locus and schizophrenia

1999 • 42 citations

Interaction between angiotensin-converting enzyme and catechol-O-methyltransferase genotypes in schizophrenics with poor response to conventional neuroleptics

2003 • 41 citations

Association study of NlaIII and MspI genetic polymorphisms of catechol-O-methyltransferase gene and susceptibility to Schizophrenia

1997 • 37 citations

The frustrating search for schizophrenia genes

2000 • 35 citations

No evidence for linkage between COMT and schizophrenia in a French population

2001 • 31 citations

Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia

2000 • 30 citations

Clinical Blood Flow Measurement with [15O] Water and Positron Emission Tomography (PET)

1995 • 27 citations

Current Progress in Schizophrenia Research

1987 • 11 citations

Phenotypes and genetic analysis of psychiatric and neuropsychiatric traits

2001 • 11 citations

CURRENT PROGRESS IN SCHIZOPHRENIA RESEARCH

2002 • 3 citations