Enzymes as Catalysts in Synthetic Organic Chemistry [New Synthetic Methods (53)]

Methods of Enzymatic Analysis

1975 • 20,446 citations

Quantitative analyses of biochemical kinetic resolutions of enantiomers

1982 • 2,569 citations

The first practical method for asymmetric epoxidation

1980 • 2,522 citations

Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis

1985 • 1,078 citations

Enzymatic Catalysis in Organic Media at 100°C

1984 • 1,040 citations

Experimental and Theoretical Aspects of Protein Folding

1975 • 965 citations

Advances in Selective Chemical Syntheses of Complex Oligosaccharides

1982 • 952 citations

The Formation of 2-Keto-3-deoxyheptonic Acid in Extracts of Escherichia coli B

1959 • 847 citations

Transcription and Translation — A Practical Approach

1985 • 811 citations

Industrial enzymology

1983 • 725 citations

Asymmetric hydrogenation

1983 • 707 citations

Primary Structure of Glycoprotein Glycans Basis for the Molecular Biology of Glycoproteins

1980 • 560 citations

The Enzymatic Synthesis of S-Adenosyl-l-homocysteine from Adenosine and Homocysteine

1959 • 546 citations

Conversion of a protein to a homogeneous asymmetric hydrogenation catalyst by site-specific modification with a diphosphinerhodium(I) moiety

1978 • 528 citations

Stereocontrol in the synthesis of acyclic systems: applications to natural product synthesis

1980 • 497 citations

Autoxidation in Food and Biological Systems

1980 • 487 citations

Stabilization of Enzymes against Thermal Inactivation

1983 • 458 citations

Immobilized Enzymes and Cells as Practical Catalysts

1983 • 452 citations

Mechanism and Stereoselectivity of Asymmetric Hydrogenation

1982 • 449 citations

Rate constants and equilibrium constants for thiol-disulfide interchange reactions involving oxidized glutathione

1980 • 400 citations

Enzymes Hosted in Reverse Micelles in Hydrocarbon Solution

1985 • 383 citations

Peroxidase-Catalyzed Halogenation

1976 • 376 citations

Transcription and translation : a Practical Approach

1984 • 375 citations

Autoxidation of methyl linoleate. Separation and analysis of isomeric mixtures of methyl linoleate hydroperoxides and methyl hydroxylinoleates

1977 • 356 citations

Doppelte Stereodifferenzierung und eine neue Strategie zur Stereokontrolle in der Organischen Synthese

1985 • 327 citations

Enzymes in organic synthesis-29

1984 • 324 citations

Artificial Enzymes

1982 • 318 citations

Selectivity: A Key to Synthetic Efficiency

1983 • 315 citations

Disulfide Bond Engineered into T4 Lysozyme: Stabilization of the Protein Toward Thermal Inactivation

1984 • 311 citations

Lignin synthesis: The generation of hydrogen peroxide and superoxide by horseradish peroxidase and its stimulation by manganese (II) and phenols

1978 • 290 citations

The Sialic Acids

1960 • 287 citations

Stereocontrolled synthesis of (+)-negamycin from an acyclic homoallylamine by 1,3-asymmetric induction

1982 • 278 citations

Enzymatic Reaction Mechanisms

1980 • 276 citations

Microbial polysaccharides and polysaccharases

1979 • 273 citations

Basic Principles of Protease‐Catalyzed Peptide Bond Formation

1985 • 271 citations

Preparative production of optically active esters and alcohols using esterase-catalyzed stereospecific transesterification in organic media

1984 • 269 citations

Enzyme immobilization by condensation copolymerization into crosslinked polyacrylamide gels

1980 • 261 citations

Enzyme-catalyzed organic synthesis: NAD(P)H cofactor regeneration by using glucose-6-phosphate and the glucose-5-phosphate dehydrogenase from Leuconostoc mesenteroides

1981 • 260 citations

The Biochemistry of Adenosylmethionine

1978 • 257 citations

Binding of substrate in a ternary complex of horse liver alcohol dehydrogenase.

1982 • 255 citations

ENZYMATIC SYNTHESIS AND BREAKDOWN OF DESOXYRIBOSE PHOSPHATE

1952 • 255 citations

Fructose-1, 6-diphosphate Aldolase UV Assay, Manuel Method

1974 • 248 citations

Enzymatic ω-Oxidation

1966 • 246 citations

Synthesis of peptide bonds by proteinases. Addition of organic cosolvents shifts peptide bond equilibriums toward synthesis

1978 • 245 citations

Applications of biochemical systems in organic chemistry

1976 • 243 citations

Microbial Asymmetric Catalysis—Enantioselective Reduction of Ketones [New Synthetic Methods (45)]

1984 • 237 citations

Methods for the analysis and preparation of adenosylmethionine and adenosylhomocysteine

1966 • 234 citations

Chiral Compounds Synthesized by Biocatalytic Reductions [New Synthetic Methods (51)]

1985 • 231 citations

S-Adenosylmethionine synthetase from Escherichia coli.

1980 • 230 citations

Lipase-catalyzed hydrolysis as a route to esters of chiral epoxy alcohols

1984 • 227 citations

[15] Phospholipase A2 (phosphatide acylhydrolase, EC 3.1.1.4) from porcine pancreas

1974 • 226 citations

Glycosyltransferases and their Use in Assessing Oligosaccharide Structure and Structure‐Function Relationships

1981 • 221 citations

Enzyme-catalyzed synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose

1982 • 215 citations

MICROBIOLOGICAL OXYGENATION OF STEROIDS AT CARBON 11

1952 • 202 citations

A Study of Stereoselective Hydrolysis of Symmetrical Diesters with Pig Liver Esterase

1983 • 201 citations

Glycoproteins: research booming on long-ignored, ubiquitous compounds

1981 • 201 citations

Chemical Mutation of Enzyme Active Sites

1984 • 199 citations

Colloidal Solution of Water in Organic Solvents: a Microheterogeneous Medium for Enzymatic Reactions

1982 • 197 citations

Enzymes in organic synthesis. 24. Preparations of enantiomerically pure chiral lactones via stereospecific horse liver alcohol dehydrogenase catalyzed oxidations of monocyclic meso diols

1982 • 196 citations

Chemical and enzymic syntheses of 5-HPETE, a key biological precursor of slow-reacting substance of anaphylaxis (SRS), and 5-HETE

1980 • 196 citations

Bifunctional chiral synthons via biochemical methods. III. Optical purity enhancement in enzymic asymmetric catalysis

1984 • 195 citations

Enantioselective synthesis of the carbocyclic nucleosides (-)-aristeromycin and (-)-neplanocin A by a chemicoenzymatic approach

1983 • 193 citations

Total Synthesis of the L-Hexoses

1983 • 190 citations

Enzyme-catalyzed organic synthesis: NADH regeneration by using formate dehydrogenase

1980 • 190 citations

Biochemistry of S-Adenosylmethionine and Related Compounds

1982 • 185 citations

Enzymatic synthesis in biphasic aqueous-organic systems. I. Chemical equilibrium shift

1981 • 182 citations

Immobilized enzymes — research and development

1979 • 180 citations

Chloroperoxidase halogenation reactions. Chemical versus enzymic halogenating intermediates.

1982 • 175 citations

Immobilized Cells and Organelles

2019 • 175 citations

Chemical and enzymatic synthesis of gene fragments

1983 • 174 citations

Oxidation of Hydrocarbons by Methane Monooxygenases from a Variety of Microbes

1980 • 173 citations

Rates of thiol-disulfide interchange reactions involving proteins and kinetic measurements of thiol pKa values

1980 • 171 citations

Structure-stability relationships in proteins: new approaches to stabilizing enzymes

1984 • 169 citations

Biocatalysis in water-organic solvent two-phase systems

1984 • 168 citations

Enzymic synthesis of hydrocarbon-soluble peptides with reverse micelles

1984 • 167 citations

New findings in methane-utilizing bacteria highlight their importance in the biosphere and their commercial potential

1980 • 165 citations

Topics in enzyme and fermentation biotechnology

1988 • 164 citations

Erythro-selective aldol reaction via tris(dialkylamino)sulfonium enolates

1981 • 159 citations

Synthese von optisch aktiven, natürlichen Carotinoiden und strukturell verwandten Naturprodukten. I. Synthese der chiralen Schlüsselverbindung (4R, 6R)‐4‐Hydroxy‐2,2,6‐trimethylcyclohexanon

1976 • 157 citations

Lipolytic Enzymes

1974 • 155 citations

Ester synthesis catalyzed by polyethylene glycol-modified lipase in benzene

1984 • 152 citations

Semi-synthesis of human insulin by trypsin-catalysed replacement of Ala-B30 by Thr in porcine insulin

1979 • 152 citations

Acyclic Stereocontrol Through the Aldol Condensation

1981 • 151 citations

Synthesis of glycerophospholipids

1980 • 150 citations

Proteinase‐Catalyzed Synthesis of Peptide Bonds

1982 • 150 citations

Biological and Biochemical Aspects of Microbial Growth on C1 Compounds

1979 • 149 citations

Two‐liquid‐phase biocatalytic reactions

1982 • 148 citations

An die Mitglieder des Vereins deutscher Chemiker

1911 • 145 citations

Enzyme-assisted semisynthesis of human insulin

1979 • 143 citations

Preparation of (R)- and (S)-mevalonic acids

1975 • 141 citations

Enzyme catalysed reactions in water - Organic solvent two-phase systems

1981 • 135 citations

Synthesis of sugars by aldolase-catalyzed condensation reactions

1983 • 135 citations

[53] Preparation of phospholipids and their analogs by phospholipase D

1981 • 134 citations

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates. IV. Stereochemical considerations of dihydrodiol formation and dehyrogenation

1970 • 132 citations

Metal ion activation of dioxygen

1981 • 131 citations

Modifizierte Ionenaustauscher als spezifische Adsorbentien

1953 • 130 citations

Industrial‐scale application of enzymes to the fats and oil industry

1984 • 129 citations

Synthesis of phosphoenolypyruvate and its use in ATP cofactor regeneration

1982 • 129 citations

A chemical modification to make horseradish peroxidase soluble and active in benzene

1984 • 128 citations

Metal ion activation of dioxygen

1980 • 128 citations

α-Chymotrypsin as the catalyst for peptide synthesis

1977 • 127 citations

Synthesis of an aspartame precursor by immobilized thermolysin in an organic solvent

1981 • 127 citations

Continuous production ofL-malic acid by immobilizedBrevibacterium ammoniagenes cells

1976 • 125 citations

Continuous synthesis of glycerides by lipase in a microporous membrane bioreactor

1984 • 124 citations

Enzyme-catalyzed organic synthesis: electrochemical regeneration of NAD(P)H from NAD(P) using methyl viologen and flavoenzymes

1981 • 123 citations

Phospholipids as Functional Constituents of Biomembranes

1984 • 120 citations

Synthesis of (S)- and (R)-4[(methoxycarbonyl)methyl]-2-azetidinone by chemicoenzymic approach

1981 • 119 citations

Sulfation of Drugs and Related Compounds

2020 • 118 citations

Microbial transformations of non-steroid cyclic compounds

1976 • 117 citations

THE MECHANISM OF “ACTIVE SULFATE” FORMATION¹

1956 • 115 citations

A new enzymatic method of acrylamide production.

1982 • 114 citations

Purification and characterization of 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli

1980 • 113 citations

[51] Production of l-amino acids by aminoacylase adsorbed on DEAE-sephadex

1976 • 110 citations

The Metabolism of l-Fucose

1962 • 109 citations

Totalsynthese von natürlichem α‐Tocopherol. 1. Mitteilung. Herstellung bifunktioneller, optisch aktiver Synthesebausteine für die Seitenkette mit Hilfe mikrobiologischer Umwandlungen

1979 • 107 citations

1 The Hexokinases

1973 • 106 citations

Cyclohexanone oxygenase: stereochemistry, enantioselectivity, and regioselectivity of an enzyme-catalyzed Baeyer-Villiger reaction

1983 • 104 citations

Bioconversion of sitosterol to useful steroidal intermediates by mutants of Mycobacterium fortuitum

1978 • 101 citations

Production and Utilization of Amino Acids

1978 • 100 citations

Stabilized soluble enzymes

1979 • 100 citations

CHEMICAL DERIVATIVES OF CHYMOTRYPSINOGEN

1956 • 99 citations

The Absolute Configuration of Dihydroxyacetone Phosphate Tritiated by Aldolase Reaction¹

1958 • 98 citations

A new cubic-space section model for predicting the specificity of horse liver alcohol dehydrogenase-catalyzed oxidoreductions

1982 • 97 citations

Analysis of Enzyme Structure and Activity by Protein Engineering

1984 • 97 citations

Synthesis with immobilized enzyme of the most important sialic acid.

1984 • 96 citations

Creation of novel chiral synthons with enzymes and applications to natural product synthesis. 15. Efficient introduction of chiral centers into cyclohexane ring

1984 • 96 citations

Biosynthesis of chondroitin sulfate. Sulfation of the polysaccharide chain

1973 • 95 citations

Potential applications of an alcohol-aldehyde/ketone oxidoreductase from thermophilic bacteria

1981 • 94 citations

Synthesis of 1'-deoxy-1'-fluorosucrose via sucrose synthetase mediated coupling of 1-deoxy-1-fluorofructose with uridine diphosphate glucose

1984 • 93 citations

Preparation of Pharmaceutical Compounds by Immobilized Enzymes and Cells

1976 • 93 citations

A Pure Enzyme Catalyzing Penicillin Biosynthesis

1984 • 92 citations

Chemical and enzymatic syntheses of 6-deoxyhexoses. Conversion to 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (Furaneol) and analogs

1983 • 92 citations

Continuous production of <scp>L</scp>‐aspartic acid by immobilized aspartase

1973 • 90 citations

The Stoichiometry of the Conversion of Cholesterol and Hydroxycholesterols to Pregnenolone (3β-Hydroxypregn-5-en-20-one) Catalysed by Adrenal Cytochrome P -450

1974 • 90 citations

Continuous Synthesis of Optically Activa α-Hydroxynitriles

1966 • 89 citations

Chemical oxidations with microorganisms

1972 • 89 citations

[41] Purification of mammalian glycosyltransferases

1982 • 89 citations

Preparative hydroxylation of aromatic compounds catalyzed by peroxidase

1981 • 88 citations

Enzymatic Syntheses of Chiral Building Blocks from Prochiral meso‐Substrates: Preparation of Methyl(hydrogen)‐1,2‐cycloalkanedicarboxylates

1984 • 87 citations

Enzymatic Oxidation of Alkyl Sulfides by Cytochrome P-450 and Hydroxyl Radical

1981 • 86 citations

Peptide synthesis in aqueous–organic solvent mixtures with α‐chymotrypsin immobilized to tresyl chloride‐activated agarose

1984 • 86 citations

Topics in enzyme and fermentation biotechnology 1

1977 • 83 citations

Stereoselective epoxidation of octadiene catalyzed by an enzyme system of Pseudomonas oleovorans

1974 • 82 citations

A Kinetic Study of Nucleotide Interactions with Pyruvate Kinase^*

1965 • 81 citations

Use of enzymes in peptide synthesis

1982 • 80 citations

Mechanistic studies on non-heme iron monooxygenase catalysis: epoxidation, aldehyde formation and demethylation by the .omega.-hydroxylation system of Pseudomonas oleovorans

1984 • 80 citations

Novel haloperoxidase substrates. Alkynes and cyclopropanes.

1983 • 80 citations

Oxidoreductase Enzymes in Biotechnology: Current Status and Future Potential

1983 • 79 citations

Microbial transformations of non-steroid cyclic compounds

1977 • 79 citations

A convenient synthesis of disodium acetyl phosphate for use in in situ ATP cofactor regeneration

1983 • 78 citations

Enantioselective and Enantioconvergent Syntheses of Building Blocks for the Total Synthesis of Cyclopentanoid Natural Products

1984 • 77 citations

Laboratory-scale enzymic/chemical syntheses of D- and L-.beta.-chlorolactic acid and D- and L-potassium glycidate

1982 • 76 citations

Deoxyribose Aldolase from Lactobacillus plantarum

1960 • 75 citations

Mikrobielle asymmetrische Katalyse — enantioselektive Reduktion von Ketonen

1984 • 75 citations

Total synthesis of carbohydrates. 3. Efficient enantioselective syntheses of 2,6-dideoxyhexoses

1983 • 75 citations

Practical synthesis of 5-phospho-D-ribosyl .alpha.-1-pyrophosphate (PRPP): enzymatic routes from ribose 5-phosphate or ribose

1983 • 74 citations

Peroxide oxidation of primary alcohols to aldehydes by chloroperoxidase catalysis

1983 • 74 citations

Phospholipide als funktionelle Bausteine biologischer Membranen

1984 • 73 citations

Biocatalysis in natural products chemistry

1984 • 72 citations

L-Rhamnulose-1-phosphate aldolase from Escherichia coli. Crystallization and properties

1969 • 72 citations

[3] Joining of RNA molecules with RNA ligase

1983 • 71 citations

Chirally selective synthesis of sugar moiety of nucleosides by chemicoenzymatic approach: L- and D-riboses, showdomycin, and cordycepin

1981 • 71 citations

Chirale Verbindungen durch biokatalytische Reduktionen

1985 • 70 citations

Enzymatic Approach to Syntheses of Unnatural Beta-Lactams

1984 • 69 citations

Preparation and use of insolubilized amyloglucosidase for the production of sweet glucose liquors

1969 • 69 citations

Hybrid organometallic/enzymic catalyst systems: regeneration of NADH using dihydrogen

1982 • 69 citations

Enzyme-catalyzed organic synthesis: regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic synthesis of deuterated substances

1983 • 69 citations

Stereochemical course of 5-lipoxygenation of arachidonate by rat basophil leukemic cell (RBL-1) and potato enzymes

1983 • 69 citations

The Optical Rotation and Configuration of a Pure Enantiomorph of Ethanol-1-d^1,2,3

1957 • 67 citations

Enzyme als Gastmoleküle in inversen Micellen

1985 • 67 citations

Nicotinamide coenzyme regeneration. Flavin mononucleotide (riboflavin phosphate) as an efficient, economical, and enzyme-compatible recycling agent

1976 • 66 citations

9-lR-linoleyl hydroperoxide, a novel product from the oxygenation of linoleic acid by type-2 lbpoxygenases from soybeans and peas

1979 • 66 citations

Electro‐Enzymatic and Electro‐Microbial Stereospecific Reductions

1981 • 66 citations

Large-scale enzyme-catalyzed synthesis of ATP from adenosine and acetyl phosphate. Regeneration of ATP from AMP

1978 • 66 citations

Grundprinzipien der proteasekatalysierten Knüpfung der Peptidbindung

1985 • 66 citations

The Synthesis of Peptides by Means of Proteolytic Enzymes

1977 • 65 citations

Bioactive Carbohydrates

2012 • 64 citations

Enzyme-catalyzed organic synthesis: NAD(P)H regeneration using dihydrogen and the hydrogenase from Methanobacterium thermoautotrophicum

1981 • 63 citations

Large-scale enzymic synthesis with cofactor regeneration: glucose 6-phosphate

1977 • 62 citations

Synthesis of the disaccharide 6-O-β-d-galactopyranosyl-2-acetamido-2-deoxy-d-galactose using immobilized β-galactosidase

1984 • 62 citations

Immobilized enzyme reaction stability: Attrition of the support material

1974 • 62 citations

Enzymes in organic synthesis. 16. Heterocyclic ketones as substrates of horse liver alcohol dehydrogenase. Stereospecific reductions of 2-substituted tetrahydrothiopyran-4-ones

1979 • 62 citations

The Microbiological Production of Industrial Chemicals

1981 • 61 citations

Herstellung und Verwendung von Aminosäuren

1978 • 60 citations

Enzyme-catalyzed organic synthesis: NAD(P)H cofactor regeneration using ethanol/alcohol dehydrogenase/aldehyde dehydrogenase and methanol/alcohol dehydrogenase/aldehyde dehydrogenase/formate dehydrogenase

1982 • 59 citations

Peptide synthesis catalyzed by papain at alkaline pH values

1984 • 59 citations

Asymmetric hydrolysis of (.+-.)-1,2-diacetoxy-3-chloropropane and its related compounds with lipase. Synthesis of optically pure (S)-propranolol.

1982 • 59 citations

Purification and Some Properties of a Hitherto‐Unknown Enzyme Reducing the Carbon‐Carbon Double Bond of α,β‐Unsaturated Carboxylate Anions

1979 • 58 citations

A new method to prepare amides by bioconversion of corresponding nitriles

1982 • 58 citations

Chirally selective synthesis of sugar moiety of nucleosides by chemicoenzymatic approach: L- and D-riboses, showdomycin, and cordycepin.

1981 • 57 citations

Biotechnology and the fats and oils industry — An overview

1984 • 57 citations

Synthesis and solution conformation of the type 2 blood group oligosaccharide .alpha.LFuc(1 .fwdarw. 2).beta.DGal(1 .fwdarw. 4).beta.DGlcNAc

1982 • 57 citations

ATP regeneration using immobilized carbamyl phosphokinase

1973 • 57 citations

[52] Production of 6-aminopenicillanic acid with immobilized Escherichia coli acylase

1976 • 55 citations

Practical enzymic syntheses of ribulose 1,5 bisphosphate and ribose 5-phosphate

1980 • 55 citations

New method for the synthesis of optically active .alpha.-amino acids and their N.alpha. derivatives via acylamino malonates

1973 • 55 citations

Multiparameter kinetic study on the unfolding and refolding of bovine carbonic anhydrase B

1980 • 55 citations

Human platelet activation by an alkylacetyl analogue of phosphatidylcholine

1982 • 54 citations

Combined electrochemical/enzymic method for in situ regeneration of NADH based on cathodic reduction of cyclic disulfides

1981 • 54 citations

Current Status of Asymmetric Synthesis

1983 • 53 citations

Studies on polynucleotides. LXXXVII. The joining of short deoxyribopolynucleotides by DNA-joining enzymes.

1968 • 52 citations

Synthesis with immobilized enzymes of two trisaccharides, one of them active as the determinant of a stage antigen.

1984 • 52 citations

Enantioselective hydrolysis of 3-hydroxy-3-methylalkanoic acid esters with pig liver esterase

1983 • 52 citations

Practical approach to high-yield enzymic stereospecific organic synthesis in multiphase systems

1981 • 51 citations

Acid-catalyzed hydration of reduced nicotinamide adenine dinucleotide and its analogs

1977 • 51 citations

Enzyme system generation of singlet (1.DELTA.g) molecular oxygen observed directly by 1.0-1.8-.mu. luminescence spectroscopy

1983 • 51 citations

Free and Immobilized Glucose Isomerase from Streptomyces phaeochromogenes

1971 • 51 citations

An efficient chemical and enzymic synthesis of nicotinamide adenine dinucleotide (NAD+)

1984 • 51 citations

Tartaric Acid Metabolism

1969 • 50 citations

Lipase-catalyzed production of optically active acids via asymmetric hydrolysis of esters

1984 • 50 citations

The regeneration of coenzymes using immobilized hydrogenase

1980 • 49 citations

Stereospecific oxidation of aliphatic alcohols catalyzed by galactose oxidase

1982 • 49 citations

L-[4-11C]aspartic acid: enzymic synthesis, myocardial uptake, and metabolism

1982 • 49 citations

A NMR shift method for determination of the enantiomeric composition of hydroperoxides formed by lipoxygenase

1979 • 49 citations

Kinetic studies of the mechanism of S-adenosylmethionine synthetase from yeast

1969 • 48 citations

Microbial and enzymatic processes for amino acid production

1978 • 47 citations

Enzymic synthesis of sn-glycerol 3-phosphate

1979 • 46 citations

The Biosynthesis of Cell Wall Lipopolysaccharide in Escherichia coli

1966 • 45 citations

[2] Using T4 RNA ligase with DNA substrates

1983 • 45 citations

Preparative production of hydroquinone from benzoquinone catalysed by immobilized d-glucose oxidase

1982 • 44 citations

Stereospecific hydrolysis by soluble and immobilized lipases

1982 • 44 citations

LIPOXYGENASE PATHWAYS

1983 • 44 citations

Enzymatic conversion of DL-.ALPHA.-amino-.EPSILON.-caprolactam into L-lysine. I. Screening, classification and distribution of L-.ALPHA.-amino-.EPSILON.-caprolactam-hydrolyzing yeasts.

1976 • 44 citations

Enzymes in organic synthesis. 31. Preparations of enantiomerically pure bicyclic [3.2.1] and [3.3.1] chiral lactones via stereospecific horse liver alcohol dehydrogenase catalyzed oxidations of meso diols

1984 • 44 citations

Enzymic synthesis of chemically unstable cardiac glycosides by β-galactosidase from Aspergillus oryzae

1984 • 42 citations

Preparation of a mixture of nucleoside triphosphates from yeast RNA: use in enzymic synthesis requiring nucleoside triphosphate regeneration and conversion to nucleoside diphosphate sugars

1983 • 42 citations

Asymmetric hydrolysis of esters by biochemical methods. Part V. Asymmetric hydrolysis of prochiral diesters with pig liver esterase. Preparation of optically active intermediates for the synthesis of (+)-biotin and (+)-.ALPHA.-methyl-3,4-dihydroxyphenylalanine.

1982 • 42 citations

Enantioselektive und enantiokonvergente Synthese von Bausteinen zur Totalsynthese cyclopentanoider Naturstoffe

1984 • 41 citations

T4 ribonucleic acid ligase joins single-strand oligo(deoxyribonucleotides)

1980 • 41 citations

5 Enzymology of Proton Abstraction and Transfer Reactions

1970 • 40 citations

Lipid Enzymes: Lipases, Lipoxygenases, and “Hydroperoxidases”

1980 • 40 citations

Comparative Studies on the Properties of Tryptophanase and Tyrosine Phenol‐lyase Immobilized Directly on Sepharose or by Use of Sepharose‐Bound Pyridoxal 5′‐Phosphate

1975 • 39 citations

Enzymes as reagents in the synthesis of peptides

1981 • 39 citations

Enzymic synthesis of dynorphin (1-8)

1982 • 38 citations

Microbial degradation of the phytosterol side chain. I. Enzymic conversion of 3-oxo-24-ethylcholest-4-en-26-oic acid into 3-oxochol-4-en-24-oic acid and androst-4-ene-3,17-dione

1982 • 38 citations

Enzymatic synthesis of arginine phosphate with coupled ATP cofactor regeneration

1984 • 38 citations

Glutathione production by immobilized Saccharomyces cerevisiae cells containing an ATP regeneration system

1981 • 38 citations

Synthesis of Phenylalanines in High Enantiomeric Excess via Enzymatic Resolution

1983 • 37 citations

[35] N-asparagine-linked oligosaccharides: Biosynthesis of the lipid-linked oligosaccharides

1982 • 37 citations

Enzymatic synthesis ofS-adenosyl-l-methionine froml-methionine and ATP

1983 • 37 citations

Enantiomeric enrichment in the hydrolysis of oxazolones catalyzed by cyclodextrins or proteolytic enzymes

1980 • 37 citations

Analyse von Struktur-Aktivitäts-Beziehungen bei Enzymen durch Protein-Engineering

1984 • 36 citations

Optimization of enzyme catalyzed peptide synthesis in a “water - water-immiscible organic solvent” biphasic system

1984 • 36 citations

REGENERATION OF NAD⁺ AND NADP⁺ COFACTORS BY PHOTOSENSITIZED ELECTRON TRANSFER

1982 • 35 citations

Specificities and properties of three reduced pyridine nucleotide-flavin mononucleotide reductases coupling to bacterial luciferase

1982 • 34 citations

Stereoselectivity in the epoxide hydrolase catalyzed hydrolysis of the stereoisomeric 3-tert-butyl-1,2-epoxycyclohexanes. Further evidence for the topology of the enzyme active site

1982 • 34 citations

[18] Synthesis of ribulose 1,5-bisphosphate: Routes from glucose 6-phosphate (via 6-phosphogluconate) and from adenosine monophosphate (via ribose 5-phosphate)

1982 • 33 citations

Coimmobilized multienzymes: An in vitro model for cellular processes

1983 • 33 citations

Enzymatische Synthesen chiraler Bausteine aus prochiralenmeso-Substraten: Herstellung von Methyl(hydrogen)-1,2-cycloalkandicarboxylaten

1984 • 33 citations

Regeneration of NAD(P)H using glucose-6-sulfate and glucose-6-phosphate dehydrogenase

1981 • 33 citations

Cholinesterase‐catalyzed resolution of <scp>D</scp>,<scp>L</scp>‐carnitine

1984 • 32 citations

A simple synthesis of dl-chalcose

1982 • 32 citations

Improved Microbial Production of Colominic Acid, a Homopolymer of N-Acetylneuraminic Acid

1973 • 32 citations

Partial Purification and Characterization of S -Adenosylhomocysteine Hydrolase Isolated from Saccharomyces cerevisiae

1972 • 31 citations

[14] Enzymic synthesis of13C-enriched aldoses, ketoses, and their phosphate esters

1982 • 31 citations

Stereochemical course of the biosynthesis of 1-aminocyclopropane-1-carboxylic acid. I. Role of the asymmetric sulfonium pole and the α-amino acid center

1984 • 31 citations

Immobilized enzymes in the production of radiopharmaceutically pure amino acids labeled with 13N.

1974 • 30 citations

Correlation studies based on enzyme structure and kinetic results: Deduction of productive substrate orientation in the active-site pocket of horse liver alcohol dehydrogenase

1981 • 29 citations

Kinetics of chymotrypsin- and papain-catalysed synthesis of [leucine]enkephalin and [methionine]enkephalin

1984 • 29 citations

Elektro‐enzymatische und elektro‐mikrobielle stereospezifische Reduktionen

1981 • 29 citations

DMSO is a substrate for chloroperoxidase

1983 • 29 citations

Enzymic epoxidation of trans,trans-1,8-dideuterio-1,7-octadiene. Analysis using partially relaxed proton Fourier transform NMR

1977 • 28 citations

濃縮と乾燥時の液状食品の芳香の回収と保存 I 加工法

1975 • 27 citations

Insolubilized Glucoamylase Enzyme System for Continuous Production of Dextrose

1972 • 27 citations

Unusual steric course of the epoxide hydrolase-catalyzed hydrolysis of (.+-.)-3,4-epoxytetrahydropyran. A case of complete stereoconvergence

1981 • 27 citations

Immobilized Glucose Isomerase for the Production of High Fructose Syrups

1974 • 27 citations

Polynucleotide phosphorylase covalently bound to cellulose and its use in the preparation of homopolynucleotides

1970 • 26 citations

An improved synthesis of diammonium acetyl phosphate

1979 • 26 citations

Scale-Up Studies on Immobilized, Purified Glucoamylase, Covalently Coupled to Porous Ceramic Support

1975 • 26 citations

[54] Scale-Up studies on immobilized, purified glucoamylase, covalently coupled to porous ceramic support

1976 • 26 citations

The enzymatic synthesis of heterogeneous dihalide derivatives: a unique biocatalytic discovery

1983 • 25 citations

Enzyme peptide synthesis by an iterative procedure in a nucleophile pool

1984 • 25 citations

A practical enzymic synthesis of (Sp)-adenosine 5'-O-(1-thiotriphosphate) ((Sp)-ATP-.alpha.-S)

1984 • 25 citations

The microbial degradation of hydrocarbons

1984 • 25 citations

The preparative synthesis of oligodeoxyribonucleotides using RNA ligase

1982 • 23 citations

Chapter 26. Enzymic Methods in Organic Synthesis

1984 • 23 citations

Large-scale synthesis of diammonium acetyl phosphate

1975 • 23 citations

Enzymatic synthesis of the penicillin and cephalosporin nuclei from an acyclic peptide containing carboxymethylcysteine

1984 • 22 citations

Synthesis of nicotinamide adenine dinucleotide (NAD) from adenosine monophosphate (AMP)

1980 • 22 citations

Insolubilized amylases

1973 • 21 citations

H. G. Gassen, A. Lang (Eds.): Chemical and Enzymatic Synthesis of Gene Fragments, Verlag Chemie Weinheim, Deerfield Beach‐Florida, Basel 1982. 260 Seiten, Preis: DM 78,—

1983 • 21 citations

Enzymatic Synthesis of a Sulfur-Analog of Penicillin Using the “cyclase” of Cephalosporium Acremonium

1984 • 20 citations

An improved synthesis of S-adenosylhomocysteine and related compounds

1984 • 20 citations

[58] On the potential of soluble and immobilized enzymes in synthetic organic chemistryf

1976 • 20 citations

Engineering enzymes

1984 • 20 citations

S-Adenosyl-L-Homocysteine: Simplified Enzymatical Preparation with High Yield

1982 • 18 citations

Conversion of the adenosine moieties of RNA into ATP for use in cofactor recycling

1979 • 18 citations

[10] Preparation, analysis, and biochemical applications of chiral methyl groups

1982 • 18 citations

Hydrolysis of adenosine 5'-triphosphate: an isotope-labeling study

1982 • 17 citations

Post-translational modification of proteins

1981 • 17 citations

Recombinant DNA Technology

1981 • 17 citations

Co-oligopeptides of glycine and aromatic amino acids with variable distance between the aromatic residues VIII. Enzymatic synthesis of N-protected dipeptide esters

1977 • 16 citations

Enzymatic Synthesis of Pyridine Nucleotides. Structural Property of Some New NAD-analogs, and Base Conditions Available for the Analog Formation

1982 • 15 citations

Microbiological Synthesis of L-dopa

1974 • 15 citations

Construction of a system for the regeneration of adenosine 5'-triphosphate, which supplies energy to bioreactor.

1984 • 15 citations

Practical enzymic synthesis of adenosine 5'-0-(3-thiotriphosphate) (ATP-.gamma.-S)

1984 • 14 citations

High yield synthesis of S-adenosylhomocysteine and related nucleosides by bacterial S-adenosylhomocysteine hydrolase.

1984 • 14 citations

Substrates of hydroxyketoglutarate aldolase

1984 • 14 citations

Synthesis by polymer-bound ribonuclease of the termination codons U-A-A, U-A-G, and U-G-A

1971 • 14 citations

Kinetically controlled equilibria the perturbation of hydrolysis equilibria in reactions catalyzed by α-chymotrypsin immobilized on charges supports

1978 • 13 citations

Synthesis of .beta.-dihydrothebaine

1978 • 13 citations

The application of coenzyme-dependent enzymes in biotechnology

1983 • 13 citations

Synthesis and properties of (4‐¹³C)NAD⁺

1984 • 13 citations

Preparation of optically pure N-tert-butyloxycarbonyl-O-benzyl-L-serine and its antipode

1978 • 13 citations

Enzyme-catalyzed transhydrogenation between nicotinamide cofactors and its application in organic synthesis

1982 • 12 citations

Use of immobilized carboxypeptidase Y (I-CPY) as a catalyst for deblocking in peptide synthesis

1980 • 12 citations

Enzymatic Synthesis of New Pyridine Nucleosides. Clitidine and Its Amide Derivative

1981 • 11 citations

Horse Liver Alcohol Dehydrogenase: An Illustrative Example of the Potential of Enzymes in Organic Synthesis

1982 • 10 citations

Enzymic resolution of (.+-.)-unsaturated cyclic terpene alcohols via asymmetric hydrolysis of corresponding acetates by microorganisms.

1980 • 10 citations

Cyclopentadiene bisadduct of tetrafluoro-p-benzoquinone: its stereochemistry, reactivity toward nucleophiles, and photochemistry

1983 • 10 citations

[Use of carrier bound leucine aminopeptidase from bovine lens for the racemic splitting of DL-amino acid amides].

1972 • 10 citations

Synthesis of (+)-marmelo lactone A and (+)-marmelo lactone B.

1983 • 10 citations

Abbau Von Steroiden

1971 • 9 citations

Applications of Cell‐Free Enzymes in Organic Synthesis

1985 • 9 citations

ChemInform Abstract: ENZYMES IN ORGANIC SYNTHESIS. 16. HETEROCYCLIC KETONES AS SUBSTRATES OF HORSE E LIVER ALCOHOL DEHYDROGENASE. STEREOSPECIFIC REDUCTIONS OF 2‐SUBSTITUTED TETRAHYDROTHIOPYRAN‐4‐ONES

1979 • 9 citations

Production of Nicotinalnide Adenine Dinucleotide by Saecharomyces carlsbergensis

1973 • 9 citations

Bioconversion of lipophilic compounds by immobilized biocatalysts in organic solvents

1983 • 9 citations

[60] Properties and applications of an immobilized mixed-function hepatic drug oxidase

1976 • 8 citations

Continuous ATP regeneration process with stable acetate kinase.

1984 • 8 citations

[59] The synthesis of porphobilinogen by immobilized δ-aminolevulinic acid dehydratase

1976 • 7 citations

Flavin Coenzyme Analogs as Probes of Flavoenzyme Reaction Mechanisms

1980 • 6 citations

Enzyme and Nonenzyme Hydrolyses of End Ester Group in Polyethylene Glycol Esters

1984 • 5 citations

ChemInform Abstract: AN EFFICIENT CHEMICAL AND ENZYMIC SYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+)

1984 • 5 citations

Industrial Enzymes from Microbial Sources. Herausgeg. von M. G. Halpern. Noyes Data Corp., Park Ridge – New Jersey/USA 1981. 1. Aufl., XII, 346 S., geb., $ 45,00

1983 • 3 citations

Enzymatic preparation of [U-14C]-4-chloronitrosobenzene

1983 • 3 citations

A BASIC STUDY ON THE CHANGES IN HEIGHT OF WAVES ON OPPOSING NON-UNIFORM CURRENTS

1975 • 1 citations