Disulfide Bond Engineered into T4 Lysozyme: Stabilization of the Protein Toward Thermal Inactivation

[2] New M13 vectors for cloning

1983 • 5,402 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

The tac promoter: a functional hybrid derived from the trp and lac promoters.

1983 • 1,001 citations

Experimental and Theoretical Aspects of Protein Folding

1975 • 965 citations

Disulphide bridges in globular proteins

1981 • 770 citations

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

1982 • 348 citations

Exploring structural homology of proteins

1976 • 289 citations

Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation

1983 • 268 citations

Real-Time Color Graphics in Studies of Molecular Interactions

1981 • 229 citations

Purification of Bacteriophage T4 Lysozyme

1968 • 225 citations

Molecular basis of thermostability in the lysozyme from bacteriophage T4

1979 • 212 citations

Directed Mutagenesis of Dihydrofolate Reductase

1983 • 210 citations

The Three Dimensional Structure of the Lysozyme from Bacteriophage T4

1974 • 177 citations

Role of primary structure and disulfide bond formation in beta-lactamase secretion

1983 • 170 citations

Protein Engineering

1983 • 163 citations

A large increase in enzyme–substrate affinity by protein engineering

1984 • 147 citations

Structure of the lysozyme from bacteriophage T4: An electron density map at 2.4 Å resolution

1978 • 132 citations

Stability of phage T4 lysozymes I. Native properties and thermal stability of wild type and two mutant lysozymes

1977 • 125 citations

Conformational changes associated with proteolytic processing of presecretory proteins allow glutathione-catalyzed formation of native disulfide bonds.

1982 • 125 citations

Assignment of the disulphide bonds of leukocyte interferon

1981 • 104 citations

Relation between hen egg white lysozyme and bacteriophage T4 lysozyme: Evolutionary implications

1981 • 93 citations

Thermodynamics of protein cross-links

1978 • 85 citations

Regeneration of ribonuclease A from the reduced protein. 1. Rate-limiting steps

1982 • 84 citations

Phage T4 lysozyme Physical properties and reversible unfolding

1975 • 70 citations

Regeneration of ribonuclease A from the reduced protein. Isolation and identification of intermediates and equilibrium treatment

1981 • 66 citations

Roles of the 29-138 disulfide bond of subtype A of human .alpha. interferon in its antiviral activity and conformational stability

1984 • 66 citations

Mutations and protein stability

1981 • 54 citations

Regeneration of ribonuclease A from the reduced protein. 1. Conformational analysis of the intermediates by measurements of enzymic activity, optical density, and optical rotation

1980 • 48 citations

Expression in escherichia coli of a chemically synthesized gene for a “mini-c” analog of human proinsulin

1981 • 47 citations

Evidence for intermediates during unfolding and refolding of a two-domain protein: phage T4 lysozyme equilibrium and kinetic studies

1984 • 37 citations

Stability of phage T4 lysozomes

1979 • 24 citations

Innovation needs information

1983 • 9 citations

Existence of intermediates in the refolding of T4 lysozyme at pH 7.4

1981 • 9 citations

Immunochemical study of phage T4 lysozyme

1981 • 1 citations