New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo.

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase

1975 • 2,622 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

1982 • 937 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

Detection of Single Base Substitutions by Ribonuclease Cleavage at Mismatches in RNA:DNA Duplexes

1985 • 538 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

1985 • 320 citations

beta 0 thalassemia, a nonsense mutation in man.

1979 • 291 citations

Biochemical method for mapping mutational alterations in DNA with S1 nuclease: the location of deletions and temperature-sensitive mutations in simian virus 40.

1975 • 264 citations

Hemoglobin: Molecular, genetic and clinical aspects

1987 • 248 citations

Allele-Specific Hybridization Using Oligonucleotide Probes of Very High Specific Activity: Discrimination of the Human β^A- and β^S-Globin Genes

1984 • 129 citations

mRNA-deficint β^°-thaladssemia results from a single nucleotide deletion

1982 • 111 citations

Beta O-39 thalassemia gene: a premature termination codon causes beta- mRNA deficiency without affecting cytoplasmic beta-mRNA stability

1984 • 106 citations

Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon

1984 • 102 citations

Structure and expression of a cloned β°thalassaemic globin gene

1981 • 85 citations

The spectrum of beta-thalassemia genes in China and Southeast Asia

1986 • 80 citations

A new mutation in IVS-1 of the human beta globin gene causing beta thalassemia due to abnormal splicing

1987 • 71 citations

β-Thalassemia resulting from a single nucleotide substitution in an acceptor splice site

1985 • 64 citations

Suppression of the nonsense mutation in homozygous β0 thalassaemia

1979 • 53 citations

The same “TATA” box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

1986 • 48 citations

A β°-thalassemic β-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells

1985 • 27 citations

A novel basis for delta beta-thalassemia in a Chinese family

1986 • 8 citations