Activation of pyk2/Related Focal Adhesion Tyrosine Kinase and Focal Adhesion Kinase in Cardiac Remodeling

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

1992 • 656 citations

Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.

1991 • 517 citations

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1998 • 467 citations

Increased Protein Kinase C Activity and Expression of Ca ²⁺ -Sensitive Isoforms in the Failing Human Heart

1999 • 447 citations

Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy

1997 • 388 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

1996 • 347 citations

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1998 • 339 citations

Characterization of Tyrosine Phosphorylation of Paxillin in Vitro by Focal Adhesion Kinase

1995 • 334 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts

1994 • 278 citations

Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes.

1992 • 275 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

The cellular basis of dilated cardiomyopathy in humans

1995 • 261 citations

Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade

1999 • 259 citations

Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin

1999 • 249 citations

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

1997 • 234 citations

Focal Adhesion Kinase Tyrosine-861 Is a Major Site of Phosphorylation by Src

1996 • 224 citations

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

2000 • 176 citations

Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase

1997 • 167 citations

Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.

1998 • 160 citations

Pulsatile Stretch Activates Mitogen-Activated Protein Kinase (MAPK) Family Members and Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes

1999 • 160 citations

Early Activation of the Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced by Pressure Overload in the Rat Heart

2000 • 149 citations

Cardiac-Specific IGF-1 Expression Attenuates Dilated Cardiomyopathy in Tropomodulin-Overexpressing Transgenic Mice

2002 • 145 citations

Association of Tyrosine-phosphorylated c-Src with the Cytoskeleton of Hypertrophying Myocardium

1997 • 144 citations

Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association

2002 • 143 citations

A Role for Focal Adhesion Kinase in Phenylephrine-induced Hypertrophy of Rat Ventricular Cardiomyocytes

2000 • 141 citations

Integrin Activation and Focal Complex Formation in Cardiac Hypertrophy

2000 • 138 citations

Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)

1998 • 137 citations

Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism

1999 • 133 citations

Ca2+ currents in compensated hypertrophy and heart failure

1998 • 131 citations

Phosphorylation of Troponin I Controls Cardiac Twitch Dynamics

2002 • 124 citations

Paxillin Is Tyrosine-phosphorylated by and Preferentially Associates with the Calcium-dependent Tyrosine Kinase in Rat Liver Epithelial Cells

1997 • 118 citations

Regulation of a Calcium-dependent Tyrosine Kinase in Vascular Smooth Muscle Cells by Angiotensin II and Platelet-derived Growth Factor

1998 • 116 citations

A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle

2001 • 107 citations

RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes

1997 • 107 citations

Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase

1999 • 101 citations

Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium.

1998 • 94 citations

Role of Calcium-Sensitive Tyrosine Kinase Pyk2/CAKβ/RAFTK in Angiotensin II–Induced Ras/ERK Signaling

1998 • 80 citations

Inhibition of PYK2-induced actin cytoskeleton reorganization, PYK2 autophosphorylation and focal adhesion targeting by FAK

2001 • 80 citations

Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125 ^FAK ) in Cultured Rat Cardiac Myocytes

1999 • 74 citations

Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells.

1997 • 72 citations

PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy

2002 • 54 citations

Pathogenesis of Dilated Cardiomyopathy

1999 • 54 citations

Characterization of the Tyrosine Kinases RAFTK/Pyk2 and FAK in Nerve Growth Factor-induced Neuronal Differentiation

2000 • 53 citations

Hypoxia Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes

1999 • 52 citations

PYK2 Expression and Phosphorylation in Neonatal and Adult Cardiomyocytes

2001 • 42 citations

Changing the remodeling process in heart failure: basic mechanisms and laboratory results.

1998 • 41 citations

Linkage of Caspase-mediated Degradation of Paxillin to Apoptosis in Ba/F3 Murine Pro-B Lymphocytes

2002 • 38 citations

RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3‐kinase

2001 • 25 citations