Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

2001 • 4,289 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

1997 • 1,993 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

2001 • 1,843 citations

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

1997 • 1,246 citations

Interleukin-6-deficient mice develop mature-onset obesity

2002 • 1,197 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

2002 • 973 citations

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

1994 • 792 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor- , in Vivo

1997 • 677 citations

Muscle‐derived interleukin‐6: possible biological effects

2001 • 580 citations

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

2001 • 577 citations

Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes

2000 • 554 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

2001 • 536 citations

Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway

2001 • 529 citations

SOCS: physiological suppressors of cytokine signaling

2000 • 457 citations

SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling

2000 • 454 citations

SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

2001 • 449 citations

Mouse liver cell culture

1981 • 397 citations

Dose-Dependent Effects of Recombinant Human Interleukin-6 on Glucose Regulation

1997 • 309 citations

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1994 • 305 citations

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

1997 • 277 citations

Suppressors of Cytokine Signaling-1 and -6 Associate with and Inhibit the Insulin Receptor

2001 • 269 citations

The cancer anorexia-cachexia syndrome.

1994 • 262 citations

Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness

1999 • 253 citations

Interleukin-6 gene polymorphism and insulin sensitivity.

2000 • 249 citations

TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C₂C₁₂muscle cells

1999 • 237 citations

An in Vivo Model for Elucidation of the Mechanism of Tumor Necrosis Factor-α (TNF-α)-Induced Insulin Resistance: Evidence for Differential Regulation of Insulin Signaling by TNF-α

1998 • 157 citations

Signal Transducer and Activator of Transcription (Stat)-Induced Stat Inhibitor 1 (Ssi-1)/Suppressor of Cytokine Signaling 1 (Socs1) Inhibits Insulin Signal Transduction Pathway through Modulating Insulin Receptor Substrate 1 (Irs-1) Phosphorylation

2001 • 155 citations

Expression of suppressors of cytokine signaling during liver regeneration

2001 • 152 citations

Interleukin 1? and interleukin 6, but not tumor necrosis factor ?, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes

1998 • 135 citations

Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle

2000 • 134 citations

Interleukin-6 Enhances Glucose Transport in 3T3-L1 Adipocytes

1996 • 118 citations

Growth Hormone Induces Cellular Insulin Resistance by Uncoupling Phosphatidylinositol 3-Kinase and Its Downstream Signals in 3T3-L1 Adipocytes

2001 • 106 citations

Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.

2000 • 90 citations

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice

1997 • 74 citations

IL-6 is essential in TNF-α-induced fever

1998 • 68 citations

Augmented Production of Tumor Necrosis Factor-α in Obese Mice

1995 • 67 citations

Compartmentalization and Insulin-Induced Translocations of Insulin Receptor Substrates, Phosphatidylinositol 3-Kinase, and Protein Kinase B in Rat Liver**This work was supported by grants from the Medical Research Council and from the National Cancer Institute of Canada, and by the Cleghorn Fund at McGill University and the M. Pollack Foundation of Montreal.

2000 • 34 citations

Hyperglycaemia due to insulin resistance caused by interferon-γ

1998 • 34 citations

FACTORS INFLUENCING THE EFFECT OF THE SOLUBLE IL-6 RECEPTOR ON IL-6 RESPONSES IN HepG2 HEPATOCYTES

2000 • 24 citations

Cytokine-mediated differential induction of hepatic activator protein-1 genes

1998 • 8 citations

Making sense of oxygen sensing

2001 • 4 citations