Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

1996 • 864 citations

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

1997 • 798 citations

Depot- and Sex-Specific Differences in Human Leptin mRNA Expression: Implications for the Control of Regional Fat Distribution

1997 • 554 citations

Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

1996 • 505 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

Adipose tissue leptin production and plasma leptin kinetics in humans

1996 • 356 citations

Effects of endotoxin and cytokines on lipid metabolism

1994 • 308 citations

Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte‐stimulating factor in the rat

1988 • 298 citations

Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia.

1992 • 283 citations

Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man

1989 • 196 citations

Aromatase activity and interleukin-6 production by normal and malignant breast tissues.

1995 • 193 citations

Metabolic characteristics of human adipose tissue in vivo

1989 • 176 citations

Insulin resistance: an adaptation for weight maintenance

1992 • 169 citations

Control of aromatase activity in breast cancer cells: The role of cytokines and growth factors

1993 • 113 citations

Cytokines and hypothalamic-pituitary function

1993 • 109 citations

CNS regulation of thermogenesis.

1994 • 107 citations

Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumour necrosis factor-

1992 • 85 citations

Interleukin‐6 an endocrine cytokine

1994 • 77 citations

Characterization of differentiation factor/leukaemia inhibitory factor effect of lipoprotein lipase activity and mRNA in 3T3-L1 adipocytes

1994 • 76 citations

Assessment of Adipose Tissue Metabolism in Man: Comparison of Fick and Microdialysis Techniques

1993 • 76 citations

Modification and validation of a commercially available portable detector for measurement of adipose tissue blood flow

1995 • 59 citations

Adipose Tissue Blood Flow Determined by the Washout of Locally Injected¹³³Xenon

1972 • 58 citations

Pharmacokinetics of Murine Tumor Necrosis Factor

1986 • 53 citations

Periprandial systemic and regional lipase activity in normal humans

1996 • 27 citations

Differential impact of insulin and obesity on cardiovascular risk factors in non-diabetic subjects.

1996 • 26 citations

Phenylalanine kinetics in human adipose tissue.

1996 • 18 citations

Are regional metabolic differences of adipose tissue responsible for different risks of obesity?

1988 • 11 citations

Aerosol research and technology

1977 • 5 citations