SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Obesity and insulin resistance

2000 • 3,076 citations

Obesity and the Regulation of Energy Balance

2001 • 2,387 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

2001 • 695 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

2001 • 577 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

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1998 • 523 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

SOCS: physiological suppressors of cytokine signaling

2000 • 457 citations

SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling

2000 • 454 citations

The role of TNFα in adipocyte metabolism

1999 • 427 citations

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

1998 • 415 citations

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1

2001 • 381 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1994 • 305 citations

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

2001 • 302 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase

1997 • 300 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

TNF-alpha and insulin resistance: summary and future prospects.

1998 • 280 citations

Suppressors of Cytokine Signaling-1 and -6 Associate with and Inhibit the Insulin Receptor

2001 • 269 citations

Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF-α-Mediated Insulin Resistance in Genetic Obesity**This work is supported in part by a grant from the NIH (DK-52539).

1998 • 248 citations

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.

2000 • 239 citations

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities

1995 • 220 citations

Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

1998 • 180 citations

The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1

1996 • 167 citations

Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor

1998 • 166 citations

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1998 • 155 citations

Signal Transducer and Activator of Transcription (Stat)-Induced Stat Inhibitor 1 (Ssi-1)/Suppressor of Cytokine Signaling 1 (Socs1) Inhibits Insulin Signal Transduction Pathway through Modulating Insulin Receptor Substrate 1 (Irs-1) Phosphorylation

2001 • 155 citations

Expression of suppressors of cytokine signaling during liver regeneration

2001 • 152 citations

Stat5 is a physiological substrate of the insulin receptor

1997 • 122 citations

Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues

1999 • 98 citations

Protein kinase C isoforms β 1 and β 2 inhibit the tyrosine kinase activity of the insulin receptor

1997 • 94 citations

SH2 and PTB domain interactions in tyrosine kinase signal transduction

1997 • 92 citations

Leptin Resistance of Adipocytes in Obesity: Role of Suppressors of Cytokine Signaling

2000 • 88 citations

Tumor necrosis factor α attenuates interferon‐α signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy

2001 • 74 citations

IRS Pleckstrin Homology Domains Bind to Acidic Motifs in Proteins

1998 • 73 citations

Insulin Induction of SOCS-2 and SOCS-3 mRNA Expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*

2001 • 69 citations

Heterologous Pleckstrin Homology Domains Do Not Couple IRS-1 to the Insulin Receptor

1997 • 61 citations

Identification of Stat 5B as a Substrate of the Insulin Receptor

1997 • 48 citations

Stat 5B, Activated by Insulin in a Jak-Independent Fashion, Plays a Role inGlucokinaseGene Transcription¹

2000 • 44 citations