Charged Residues between the Selectivity Filter and S6 Segments Contribute to the Permeation Phenotype of the Sodium Channel

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Ionic Channels of Excitable Membranes, 2nd Ed.

1992 • 1,283 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

The Ionic Channels in Excitable Membranes

1975 • 1,096 citations

Calcium channel characteristics conferred on the sodium channel by single mutations

1992 • 776 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

1989 • 561 citations

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II

1991 • 460 citations

Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

1996 • 451 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

1992 • 387 citations

Structure and function of voltage‐gated sodium channels

1998 • 349 citations

A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II

1989 • 336 citations

Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels

1992 • 281 citations

SULFUR IN PROTEINS

1933 • 240 citations

Suppression of Neuronal and Cardiac Transient Outward Currents by Viral Gene Transfer of Dominant-Negative Kv4.2 Constructs

1997 • 171 citations

Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator.

1994 • 146 citations

External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels.

1996 • 132 citations

K+ pore structure revealed by reporter cysteines at inner and outer surfaces

1995 • 112 citations

Molecular basis for pharmacological differences between brain and cardiac sodium channels

1992 • 111 citations

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

1996 • 111 citations

Depth Asymmetries of the Pore-Lining Segments of the Na+ Channel Revealed by Cysteine Mutagenesis

1996 • 107 citations

Side-chain accessibilities in the pore of a K+ channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis

1995 • 101 citations

Tertiary structure of conotoxin GIIIA in aqueous solution

1991 • 78 citations

A mutation in the pore of the sodium channel alters gating

1995 • 77 citations

Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.

1996 • 70 citations

Altered Ionic Selectivity of the Sodium Channel Revealed by Cysteine Mutations within the Pore

1997 • 69 citations

P-loop Flexibility in Na+ Channel Pores Revealed by Single- and Double-cysteine Replacements

1997 • 63 citations

Differential contribution by conserved glutamate residues to an ion‐selectivity site in the L‐type Ca²⁺ channel pore

1993 • 63 citations

Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating

1991 • 61 citations

Molecular motions within the pore of voltage-dependent sodium channels

1997 • 60 citations

Molecular Dynamics of the Sodium Channel Pore Vary with Gating: Interactions between P-Segment Motions and Inactivation

1999 • 59 citations

Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis.

1996 • 55 citations

Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis

1997 • 53 citations

Kinetic properties of single sodium channels modified by fenvalerate in mouse neuroblastoma cells

1989 • 46 citations

Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis

1997 • 31 citations

Local Anesthetic Anchoring to Cardiac Sodium Channels

1999 • 14 citations