Mutant Potassium Channels with Altered Binding of Charybdotoxin, a Pore-Blocking Peptide Inhibitor

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila

1987 • 721 citations

Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila

1987 • 645 citations

A transient calcium‐dependent chloride current in the immature Xenopus oocyte.

1983 • 627 citations

Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

1983 • 540 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.

1988 • 443 citations

Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel

1987 • 412 citations

Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel.

1988 • 355 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

Rational modification of enzyme catalysis by engineering surface charge

1987 • 321 citations

Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength.

1988 • 250 citations

Computer Simulations of the Diffusion of a Substrate to an Active Site of an Enzyme

1987 • 224 citations

An emerging pharmacology of peptide toxins targeted against potassium channels

1988 • 218 citations

Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes

1988 • 174 citations

The engineering of binding affinity at metal ion binding sites for the stabilization of proteins: subtilisin as a test case

1988 • 171 citations

Subset-Specific Expression of Potassium Channels in Developing Murine T Lymphocytes

1988 • 167 citations

Molecular organization of the maternal effect region of the Shaker complex of Drosophila : characterization of an I_A channel transcript with homology to vertebrate Na⁺ channel

1987 • 163 citations

Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features

1988 • 155 citations

Role of surface electrostatics in the operation of a high-conductance calcium-activated potassium channel

1989 • 153 citations

Charybdotoxin selectively blocks small Ca-activated K channels in Aplysia neurons.

1987 • 141 citations

The role of protein surface charges in ion binding

1988 • 138 citations

Competition for block of a Ca2+-activated K+ channel by charybdotoxin and tetraethylammonium

1988 • 112 citations

Charybdotoxin blocks with high affinity the Ca-activated K+ channel of Hb A and Hb S red cells: Individual differences in the number of channels

1988 • 100 citations