Pharmacology of cannabinoids.

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1995 • 2,837 citations

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

1995 • 2,122 citations

The endogenous cannabinoid system controls extinction of aversive memories

2002 • 1,689 citations

Leptin-regulated endocannabinoids are involved in maintaining food intake

2001 • 1,557 citations

Pharmacology of cannabinoid CB1 and CB2 receptors

1997 • 1,448 citations

Pharmacokinetics and Pharmacodynamics of Cannabinoids

2003 • 1,322 citations

Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: Basic findings from the National Comorbidity Survey.

1994 • 1,279 citations

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

2001 • 1,212 citations

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ ₁ Opioid Receptor Mechanism

1997 • 1,078 citations

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

2002 • 959 citations

Cognitive Functioning of Long-term Heavy Cannabis Users Seeking Treatment

2002 • 785 citations

2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB ₁ receptor

2001 • 752 citations

Triggering Myocardial Infarction by Marijuana

2001 • 728 citations

Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

2000 • 672 citations

Neuropsychological Performance in Long-term Cannabis Users

2001 • 649 citations

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

2000 • 632 citations

Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor

2002 • 601 citations

Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects

1982 • 582 citations

Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain

2001 • 541 citations

HU-308: A specific agonist for CB ₂ , a peripheral cannabinoid receptor

1999 • 540 citations

Early-onset cannabis use and cognitive deficits: what is the nature of the association?

2003 • 522 citations

The cannabinoid receptors

2002 • 503 citations

Cannabis: pharmacology and toxicology in animals and humans

1996 • 490 citations

Pain modulation by release of the endogenous cannabinoid anandamide

1999 • 482 citations

Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana

2003 • 449 citations

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

1998 • 415 citations

Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor

2001 • 414 citations

Endocannabinoids control spasticity in a multiple sclerosis model

2000 • 378 citations

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors

2003 • 370 citations

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain

1998 • 351 citations

The therapeutic potential of cannabis

2003 • 340 citations

‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance

1998 • 317 citations

A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation

2002 • 304 citations

Cannabis and Cannabis Extracts

2001 • 299 citations

Inhibition of tumor angiogenesis by cannabinoids

2003 • 294 citations

CLINICAL STUDIES OF CANNABIS TOLERANCE AND DEPENDENCE*

1976 • 269 citations

Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1

2000 • 266 citations

Biphasic Effects of Anandamide

1998 • 258 citations

Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells.

1993 • 239 citations

Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects

2002 • 235 citations

Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.

2001 • 226 citations

Cannabinoids, hippocampal function and memory

1999 • 219 citations

Δ9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells

2002 • 219 citations

Cannabinoids Acting on CB1 Receptors Decrease Contractile Performance in Human Atrial Muscle

2003 • 218 citations

Marihuana, the Forbidden Medicine

1993 • 215 citations

Bidirectional control of airway responsiveness by endogenous cannabinoids

2000 • 215 citations

Acute cardiovascular fatalities following cannabis use

2001 • 205 citations

Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors.

1997 • 196 citations

Observational analysis of feeding induced by Δ9-THC and anandamide

2002 • 195 citations

Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons

1995 • 182 citations

Neuroprotection by Δ⁹-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-InducedIn VivoExcitotoxicity

2001 • 176 citations

Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB1 receptors

2001 • 171 citations

Enhancement of Anandamide Formation in the Limbic Forebrain and Reduction of Endocannabinoid Contents in the Striatum of Δ⁹‐Tetrahydrocannabinol‐Tolerant Rats

2000 • 165 citations

Cardiovascular effects of prolonged delta‐9‐tetrahydrocannabinol ingestion

1975 • 163 citations

Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response

1999 • 162 citations

Dexanabinol (HU-211) in the treatment of severe closed head injury: A randomized, placebo-controlled, phase II clinical trial*

2002 • 159 citations

Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system

2001 • 152 citations

Delta‐9‐tetrahydrocannabinol delays the gastric emptying of solid food in humans: a double‐blind, randomized study

1999 • 152 citations

Antinociceptive Synergy between Δ⁹-Tetrahydrocannabinol and Opioids after Oral Administration

2002 • 149 citations

Open label evaluation of cannabidiol in dystonic movement disorders

1986 • 147 citations

Effects of chronic exposure to Δ9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions

1997 • 147 citations

Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor

2003 • 133 citations

The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice

2001 • 128 citations

Interactions ofΔ 11-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentographywith cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentography

1981 • 118 citations

Comparison of acute oral toxicity of cannabinoids in rats, dogs and monkeys

1973 • 116 citations

Toxicity and Carcinogenicity of Δ9-Tetrahydrocannabinol in Fischer Rats and B6C3F1 Mice

1996 • 115 citations

Cardiovascular actions of cannabinoids and their generation during shock

1998 • 112 citations

Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats

2002 • 107 citations

Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain

2001 • 106 citations

Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting

1991 • 104 citations

CHANGES IN HUMAN SPERMATOZOA ASSOCIATED WITH HIGH DOSE MARIHUANA SMOKING

1979 • 104 citations

Evidence for a cannabinoid receptor in sea urchin sperm and its role in blockade of the acrosome reaction

1993 • 104 citations

Changes in the Cannabinoid Receptor Binding, G Protein Coupling, and Cyclic AMP Cascade in the CNS of Rats Tolerant to and Dependent on the Synthetic Cannabinoid Compound CP55,940

2000 • 104 citations

Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes

2002 • 101 citations

Delta-9-tetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indices of motor function via cannabinoid CB1 receptors in the least shrew

2001 • 101 citations

Treatment of Tourette Syndrome with Delta-9-Tetrahydrocannabinol (Δ9-THC): No Influence on Neuropsychological Performance

2003 • 101 citations

Abuse Potential of Dronabinol (Marinol®)

1998 • 98 citations

Cannabis‐induced psychosis: a cross‐sectional comparison with acute schizophrenia

2002 • 93 citations

Cannabis Use and Cognitive Decline in Persons under 65 Years of Age

1999 • 92 citations

Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil

2000 • 92 citations

Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents.

1989 • 88 citations

Interaction between naltrexone and oral THC in heavy marijuana smokers

2003 • 82 citations

Characterization of Cytochrome P450 3A Inactivation by Cannabidiol: Possible Involvement of Cannabidiol-Hydroxyquinone as a P450 Inactivator

1998 • 77 citations

Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.

1995 • 74 citations

Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.

1995 • 72 citations

Functional Role for Cannabinoids in Respiratory Stability During Sleep

2002 • 71 citations

The therapeutic potential of the cannabinoids in neuroprotection

2002 • 71 citations

Effects of Cannabinoids on Sympathetic and Parasympathetic Neuroeffector Transmission in the Rabbit Heart

2001 • 68 citations

Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice ☆

2003 • 66 citations

CB₁ cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction

2003 • 61 citations

Observations on the effects of four weeks of heavy marihuana smoking on group interaction and individual behavior

1979 • 60 citations

Inhibitory effect of the cannabinoid receptor agonist WIN 55,212-2 on pentagastrin-induced gastric acid secretion in the anaesthetized rat

1999 • 57 citations

Naltrexone does not block the subjective effects of oral Δ9-tetrahydrocannabinol in humans

2000 • 56 citations

Chronic Cannabis Use in the Compassionate Investigational New Drug Program

2002 • 53 citations

Antagonism of marihuana effects by indomethacin in humans

1991 • 52 citations

Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man

1981 • 50 citations

Effects of Tetrahydrocannabinol on Melatonin Secretion in Man

1986 • 50 citations

Pharmacological evaluation of aerosolized cannabinoids in mice

2000 • 46 citations

Medical Efficacy of Cannabinoids and Marijuana: A Comprehensive Review of the Literature

2002 • 44 citations

Enhancement of brain [3H]flunitrazepam binding and analgesic activity of synthetic cannabimimetics

1985 • 44 citations

Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol

1984 • 39 citations

Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro

2001 • 39 citations

Cannabinoids And The Cholinergic System

1981 • 39 citations

Clinical Pharmacodynamics of Cannabinoids

2004 • 36 citations

Effects of cannabinoids (marijuana) on taste intensity and hedonic ratings and salivary flow of adults

1994 • 31 citations

Short-Term Effects of Smoked Marihuana on Left Ventricular Function in Man

1977 • 31 citations

Chronic cannabinoid, CP-55,940, administration alters biotransformation in the rat

1996 • 30 citations

Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed

2001 • 29 citations

Effects of Marihuana on Sleeping States

1972 • 28 citations

In Vivo Interactions between Psychotropic Cannabinoids and Other Drugs Involving Central and Peripheral Neurochemical Mediators

2019 • 22 citations

Sites and Mechanisms of Action

2002 • 22 citations

Topically administered CB2-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits

2002 • 20 citations

The Psychologic and Physiologic Effects of Active Cannabinoids

1999 • 17 citations