Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

A review of central 5-HT receptors and their function

1999 • 3,121 citations

Determination and characterization of a cannabinoid receptor in rat brain.

1988 • 2,339 citations

Cannabinoid receptor localization in brain.

1990 • 2,248 citations

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

1999 • 2,128 citations

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1996 • 2,079 citations

Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations

1995 • 1,689 citations

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

2001 • 1,276 citations

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

1999 • 1,060 citations

The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

2000 • 766 citations

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

1999 • 599 citations

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1996 • 555 citations

Cannabinoid receptors and their ligands

2002 • 542 citations

Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain

2001 • 541 citations

Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.

1993 • 440 citations

Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus

2001 • 421 citations

Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs

1991 • 403 citations

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB₁ Cannabinoid Receptor Knockout Mice

2000 • 399 citations

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

1994 • 383 citations

In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.

1996 • 352 citations

Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys

2000 • 344 citations

An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing

1995 • 321 citations

Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol.

1992 • 272 citations

Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.

1992 • 266 citations

Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells.

1993 • 239 citations

Structure-activity relationships of indole- and pyrrole-derived cannabinoids.

1998 • 231 citations

Anandamide receptors

2002 • 231 citations

Synergistic interactions of endogenous opioids and cannabinoid systems

1999 • 164 citations

Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain.

1998 • 162 citations

The biodisposition and metabolism of anandamide in mice.

1997 • 154 citations

Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids.

1999 • 134 citations

Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs.

1995 • 133 citations

Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys.

1995 • 125 citations

Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor

1990 • 119 citations

Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A.

1998 • 117 citations

Highly Selective CB1 Cannabinoid Receptor Ligands and Novel CB1/VR1 Vanilloid Receptor “Hybrid” Ligands

2001 • 116 citations

Cannabimimetic Fatty Acid Derivatives: The Anandamide Family and Other 'Endocannabinoids'

1999 • 113 citations

Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes.

1998 • 112 citations

Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: fluorescence studies.

1985 • 96 citations

A Structure/Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid

2002 • 87 citations

The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity.

1997 • 85 citations

Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide

2000 • 82 citations

Novel, Not Adenylyl Cyclase-Coupled Cannabinoid Binding Site in Cerebellum of Mice

2002 • 75 citations

Discriminative stimulus effects of anandamide in rats

1995 • 74 citations

Pharmacological and behavioral evaluation of alkylated anandamide analogs

1995 • 67 citations

Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Δ9-THC and anandamide1Published on the World Wide Web on 18 January 2000.1

2000 • 67 citations

Cannabis

1999 • 63 citations

Potent Anandamide Analogs: The Effect of Changing the Length and Branching of the End Pentyl Chain

1997 • 62 citations

Serotonin Receptor and Transporter Ligands - Current Status

2001 • 61 citations

Synthesis and Pharmacological Comparison of Dimethylheptyl and Pentyl Analogs of Anandamide

1997 • 59 citations

Evaluation of Cannabimimetic Discriminative Stimulus Effects of Anandamide and Methylated Fluoroanandamide in Rhesus Monkeys

1997 • 55 citations

Immune regulation by cannabinoid compounds through the inhibition of the cyclic AMP signaling cascade and altered gene expression

1996 • 53 citations

(R)-methanandamide, but not anadamide, substitutes for Δ-9-THC in a drug-discrimination procedure.

1997 • 48 citations

Cannabinoid properties of methylfluorophosphonate analogs.

2000 • 46 citations

A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes

1993 • 45 citations

Evaluation of cannabimimetic effects of structural analogs of anandamide in rats

1998 • 41 citations

(R)-methanandamide, but not anadamide, substitutes for Δ–9-THC in a drug-discrimination procedure.

1997 • 39 citations

Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects

2000 • 27 citations

Paradoxical Pharmacological Effects of Deoxy-Tetrahydrocannabinol Analogs Lacking High CB<sub>1</sub> Receptor Affinity

2002 • 17 citations