Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1995 • 2,837 citations

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

1995 • 2,122 citations

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1996 • 2,079 citations

Vanilloid (Capsaicin) receptors and mechanisms.

1999 • 1,825 citations

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

1994 • 1,564 citations

A second endogenous cannabinoid that modulates long-term potentiation

1997 • 1,474 citations

Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition

1997 • 806 citations

Dopamine activation of endogenous cannabinoid signaling in dorsal striatum

1999 • 773 citations

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

1993 • 695 citations

Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

2000 • 672 citations

Chemical Characterization of a Family of Brain Lipids That Induce Sleep

1995 • 605 citations

Pain modulation by release of the endogenous cannabinoid anandamide

1999 • 482 citations

The endocannabinoid system as a target for therapeutic drugs

2000 • 427 citations

Molecular characterization of human and mouse fatty acid amide hydrolases

1997 • 426 citations

Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes

1997 • 372 citations

Production and physiological actions of anandamide in the vasculature of the rat kidney.

1997 • 363 citations

(R)-Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability

1994 • 346 citations

Accumulation of N‐Arachidonoylethanolamine (Anandamide) into Cerebellar Granule Cells Occurs via Facilitated Diffusion

1997 • 337 citations

Anandamide Amidohydrolase Activity in Rat Brain Microsomes

1995 • 331 citations

Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand

1998 • 325 citations

A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.

1998 • 316 citations

Partial Purification and Characterization of the Porcine Brain Enzyme Hydrolyzing and Synthesizing Anandamide

1995 • 305 citations

Biosynthesis and inactivation of the endocannabinoid 2‐arachidonoylglycerol in circulating and tumoral macrophages

1999 • 295 citations

Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock

1997 • 288 citations

Structural determinants for recognition and translocation by the anandamide transporter

1999 • 270 citations

Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

2000 • 267 citations

Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1

2000 • 266 citations

Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation

1997 • 256 citations

Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

2000 • 237 citations

Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro.

2000 • 235 citations

Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol

2000 • 231 citations

Reversal of Dopamine D₂Receptor Responses by an Anandamide Transport Inhibitor

2000 • 226 citations

Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors

1999 • 216 citations

Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development

2000 • 207 citations

Anandamide Hydrolysis by Human Cells in Culture and Brain

1998 • 196 citations

Anandamide Uptake by Human Endothelial Cells and Its Regulation by Nitric Oxide

2000 • 189 citations

Endocannabinoids and vascular function.

2000 • 179 citations

Spinal cannabinoids are anti-allodynic in rats with persistent inflammation

1999 • 167 citations

Quantification of Bioactive Acylethanolamides in Rat Plasma by Electrospray Mass Spectrometry

2000 • 166 citations

Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system

1997 • 166 citations

Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells.

2000 • 145 citations

Chemical and Mutagenic Investigations of Fatty Acid Amide Hydrolase: Evidence for a Family of Serine Hydrolases with Distinct Catalytic Properties

1999 • 144 citations

Fatty Acid Amide Hydrolase Competitively Degrades Bioactive Amides and Esters through a Nonconventional Catalytic Mechanism

1999 • 134 citations

Fatty Acid Sulfonyl Fluorides Inhibit Anandamide Metabolism and Bind to the Cannabinoid Receptor

1997 • 133 citations

Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404

2000 • 131 citations

Structure—Activity Relationships Among N‐Arachidonylethanolamine (Anandamide) Head Group Analogues for the Anandamide Transporter

2000 • 128 citations

Distribution of anandamide amidohydrolase in rat tissues with special reference to small intestine

1997 • 125 citations

Catabolism of N‐Acylethanolamine Phospholipids by Dog Brain Preparations

1984 • 122 citations

Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase

1999 • 112 citations

Cardiovascular actions of cannabinoids and their generation during shock

1998 • 112 citations

Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells

1998 • 100 citations

An acid amidase hydrolyzing anandamide as an endogenous ligand forcannabinoid receptors

1999 • 99 citations

Potentiation of anandamide hypotension by the transport inhibitor, AM404

1997 • 94 citations

Anandamide activates human platelets through a pathway independent of the arachidonate cascade

1999 • 83 citations

Inhibition of intestinal motility by anandamide, an endogenous cannabinoid.

1997 • 80 citations

Cannabinoid modulation of intestinal propulsion in mice

1998 • 78 citations

A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols

2000 • 78 citations

The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine

1997 • 70 citations

Structure-activity relationships of anandamide, an endogenous cannabinoid ligand

1999 • 59 citations

Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide

1999 • 56 citations

Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374)

1999 • 50 citations

A role for the endogenous cannabinoid system in the peripheal control of pain initiation

2000 • 37 citations

Exposure of piglet coronary arterial muscle cells to low concentrations of Mg2+ found in blood of ischemic heart disease patients result in rapid elevation of cytosolic Ca2+: Relevance to sudden infant death syndrome

1997 • 21 citations