Cationic Sites on Granzyme B Contribute to Cytotoxicity by Promoting Its Uptake into Target Cells

Regulated portals of entry into the cell

2003 • 3,642 citations

Molecular modeling of protein-glycosaminoglycan interactions.

1989 • 1,288 citations

Functional significance of the perforin/granzyme cell death pathway

2002 • 1,186 citations

Lymphocyte-Mediated Cytotoxicity

2002 • 1,079 citations

Cytotoxic T lymphocytes: all roads lead to death

2002 • 893 citations

Animal cell mutants defective in glycosaminoglycan biosynthesis.

1985 • 587 citations

Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins

1998 • 541 citations

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

2004 • 519 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis

2000 • 393 citations

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1996 • 368 citations

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

2000 • 361 citations

Chlorate — a potent inhibitor of protein sulfation in intact cells

1986 • 353 citations

Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O

2001 • 324 citations

Cytotoxic Cell Granule-Mediated Apoptosis

2002 • 297 citations

A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis.

1992 • 286 citations

Glycosylation of Pichia pastoris ‐derived proteins

1999 • 281 citations

A Novel Ligand for CD44 Is Serglycin, a Hematopoietic Cell Lineage-specific Proteoglycan

1995 • 272 citations

Granzyme B: pro-apoptotic, antiviral and antitumor functions

2003 • 247 citations

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

1997 • 237 citations

Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin

1999 • 214 citations

Entry and Trafficking of Granzyme B in Target Cells During Granzyme B-Perforin–Mediated Apoptosis

1998 • 210 citations

Nuclear war: the granzyme A-bomb

2003 • 198 citations

Cell Surface-bound Heat Shock Protein 70 (Hsp70) Mediates Perforin-independent Apoptosis by Specific Binding and Uptake of Granzyme B

2003 • 189 citations

Phosphohexosyl recognition is a general characteristic of pinocytosis of lysosomal glycosidases by human fibroblasts.

1977 • 181 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Perforin and the granule exocytosis cytotoxicity pathway

2003 • 166 citations

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

2003 • 154 citations

Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling

2003 • 116 citations

Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein [published erratum appears in J Cell Biol 1995 Aug;130(4):1015]

1995 • 110 citations

A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death

2003 • 110 citations

The genes for perforin, granzymes A–C and IFN‐γ are differentially expressed in single CD8+ T cells during primary activation

2002 • 103 citations

The Low Density Lipoprotein Receptor-related Protein Complexes with Cell Surface Heparan Sulfate Proteoglycans to Regulate Proteoglycan-mediated Lipoprotein Catabolism

2003 • 82 citations

Biosynthesis and Processing of Proteinase 3 in U937 Cells

1996 • 79 citations

Granzyme B Binds to Target Cells Mostly by Charge and Must Be Added at the Same Time as Perforin to Trigger Apoptosis

2005 • 78 citations

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

2001 • 77 citations

The N-terminal Arg2, Arg3 and Arg4 of human lactoferrin interact with sulphated molecules but not with the receptor present on Jurkat human lymphoblastic T-cells

1997 • 76 citations

Importance of the P4′ Residue in Human Granzyme B Inhibitors and Substrates Revealed by Scanning Mutagenesis of the Proteinase Inhibitor 9 Reactive Center Loop

2001 • 73 citations

Expression of Active Streptolysin O in Escherichia coli as a Maltose‐Binding‐Protein‐Streptolysin‐O Fusion Protein

1996 • 69 citations

Functional domains of the receptor-associated protein (RAP).

1994 • 65 citations

Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism

2003 • 64 citations

Immunopurification of Functional Asp-ase (Natural Killer Cell Granzyme B) Using a Monoclonal Antibody

1993 • 61 citations

Expression and Purification of Recombinant Human Granzyme B from Pichia pastoris

1999 • 59 citations

Membrane receptors are not required to deliver granzyme B during killer cell attack

2004 • 59 citations

Granzyme-mediated Cytotoxicity Does Not Involve the Mannose 6-Phosphate Receptors on Target Cells

2004 • 58 citations

Intracellular Cycling of Lysosomal Enzyme Receptors

2001 • 55 citations

A Novel Mechanism for Protein Delivery

2005 • 54 citations

Apoptosis Induced by Granzyme B-Glycosaminoglycan Complexes: Implications for Granule-Mediated Apoptosis In Vivo

1999 • 54 citations

Homobifunctional Cross-linkers

1996 • 54 citations

The granzyme B–serglycin complex from cytotoxic granules requires dynamin for endocytosis

2004 • 51 citations

Granule serine proteases are normal nuclear constituents of natural killer cells

1994 • 49 citations

Evidence that pinocytosis in lymphoid cells has a low capacity.

1986 • 44 citations

Granzyme B Encoded by the Commonly Occurring Human RAH Allele Retains Pro-apoptotic Activity

2004 • 36 citations

Fluid phase endocytosis investigated by fluorescence with trimethylamino‐diphenylhexatriene in L929 cells; the influence of temperature and of cytoskeleton depolymerizing drugs

1991 • 28 citations

High Affinity Binding of Receptor-associated Protein to Heparin and Low Density Lipoprotein Receptor-related Protein Requires Similar Basic Amino Acid Sequence Motifs

2001 • 22 citations

Mannose 6-Phosphate Quantitation in Glycoproteins Using High-pH Anion-Exchange Chromatography with Pulsed Amperometric Detection

2002 • 20 citations

Characterization of Recombinant Mouse Perforin Expressed in Insect Cells Using the Baculovirus System

1994 • 18 citations

Tissue factor and plasminogen activator inhibitor expression in the differentiation of myeloid leukemic cells.

1993 • 10 citations