Granzyme B Encoded by the Commonly Occurring Human RAH Allele Retains Pro-apoptotic Activity

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

1999 • 1,212 citations

Functional significance of the perforin/granzyme cell death pathway

2002 • 1,186 citations

Cytotoxic T lymphocytes: all roads lead to death

2002 • 893 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA.

1991 • 780 citations

Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status

1999 • 484 citations

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis

2000 • 393 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1996 • 368 citations

A Cytosolic Granzyme B Inhibitor Related to the Viral Apoptotic Regulator Cytokine Response Modifier A Is Present in Cytotoxic Lymphocytes

1996 • 301 citations

Selective Regulation of Apoptosis: the Cytotoxic Lymphocyte Serpin Proteinase Inhibitor 9 Protects against Granzyme B-Mediated Apoptosis without Perturbing the Fas Cell Death Pathway

1998 • 295 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

2003 • 241 citations

Entry and Trafficking of Granzyme B in Target Cells During Granzyme B-Perforin–Mediated Apoptosis

1998 • 210 citations

The Intracellular Granzyme B Inhibitor, Proteinase Inhibitor 9, Is Up-Regulated During Accessory Cell Maturation and Effector Cell Degranulation, and Its Overexpression Enhances CTL Potency

2003 • 163 citations

A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death

2003 • 110 citations

The Granzyme B Inhibitor, PI-9, Is Present in Endothelial and Mesothelial Cells, Suggesting That It Protects Bystander Cells during Immune Responses

2001 • 86 citations

Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide.

1993 • 81 citations

Importance of the P4′ Residue in Human Granzyme B Inhibitors and Substrates Revealed by Scanning Mutagenesis of the Proteinase Inhibitor 9 Reactive Center Loop

2001 • 73 citations

Immunopurification of Functional Asp-ase (Natural Killer Cell Granzyme B) Using a Monoclonal Antibody

1993 • 61 citations

Expression and Purification of Recombinant Human Granzyme B from Pichia pastoris

1999 • 59 citations

Protein sorting and secretion during CTL killing

1997 • 42 citations

A triple-mutated allele of granzyme B incapable of inducing apoptosis

2003 • 40 citations

Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis

2003 • 27 citations

Characterization of Recombinant Mouse Perforin Expressed in Insect Cells Using the Baculovirus System

1994 • 18 citations

Granzyme B inhibitor I reduces apoptotic cell death of allogeneic-transplanted hepatocytes in spleen

2001 • 5 citations