A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

Functional significance of the perforin/granzyme cell death pathway

2002 • 1,186 citations

Cytotoxic T lymphocytes: all roads lead to death

2002 • 893 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin.

1995 • 400 citations

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis

2000 • 393 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1996 • 368 citations

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

2000 • 361 citations

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

1995 • 352 citations

Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

2000 • 342 citations

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax

2000 • 306 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

1997 • 237 citations

Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin

1999 • 214 citations

DFF45/ICAD Can Be Directly Processed by Granzyme B during the Induction of Apoptosis

2000 • 213 citations

Entry and Trafficking of Granzyme B in Target Cells During Granzyme B-Perforin–Mediated Apoptosis

1998 • 210 citations

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

1999 • 207 citations

The regulation of protein transport to the nucleus by phosphorylation

1995 • 181 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

1998 • 166 citations

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes.

1997 • 161 citations

Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma.

1991 • 154 citations

Interactions of recombinant and platelet transforming growth factor-β1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

1989 • 127 citations

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

2001 • 113 citations

Nuclear Transport of Granzyme B (Fragmentin-2)

1996 • 104 citations

Localization of Granzyme B in the Nucleus

1996 • 102 citations

Clathrin, Adapters, And Sorting

1990 • 89 citations

The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand.

1986 • 87 citations

Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells.

1990 • 66 citations

The Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Nanomolar Affinity Receptor for Glycosylated Human Leukemia Inhibitory Factor

1998 • 65 citations

Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas

1997 • 64 citations

Immunopurification of Functional Asp-ase (Natural Killer Cell Granzyme B) Using a Monoclonal Antibody

1993 • 61 citations