Childhood Acute Lymphoblastic Leukemia With the MLL-ENL Fusion and t(11;19)(q23;p13.3) Translocation

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Nonparametric Estimation from Incomplete Observations

1958 • 7,673 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

Secondary Acute Myeloid Leukemia in Children Treated for Acute Lymphoid Leukemia

1989 • 457 citations

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

1997 • 416 citations

Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia

1993 • 324 citations

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II

1993 • 319 citations

Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases [see comments]

1991 • 307 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 294 citations

Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study

1990 • 264 citations

Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age

1996 • 241 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 236 citations

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.

1993 • 231 citations

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

1994 • 223 citations

11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.

1994 • 212 citations

11q23 rearrangements in acute leukemia.

1996 • 197 citations

A direct bone marrow chromosome technique for acute lymphoblastic leukemia

1984 • 193 citations

Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study

1994 • 183 citations

Heterogeneity of presenting features and their relation to treatment outcome in 120 children with T-cell acute lymphoblastic leukemia

1990 • 168 citations

HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities [see comments]

1993 • 166 citations

Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group

1994 • 156 citations

Hematologic malignancies with t(4;11)(q21;q23) – a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases

1998 • 154 citations

ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

1994 • 132 citations

Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

1990 • 126 citations

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

1997 • 125 citations

Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia

1993 • 123 citations

A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias

1993 • 122 citations

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

1993 • 115 citations

The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients

1998 • 110 citations

Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia.

1996 • 106 citations

Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XII

1997 • 102 citations

Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study.

1990 • 100 citations

Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

1990 • 95 citations

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

1993 • 95 citations

Cloning of several species of MLL/MEN chimeric cDNAs in myeloid leukemia with t(11;19)(q23;p13.1) translocation

1995 • 83 citations

Prognostic relevance of ALL-1 gene rearrangement in infant acute leukemias.

1995 • 82 citations

Cytogenetic heterogeneity in t(11;19) acute leukemia: clinical, hematological and cytogenetic analyses of 48 patients--updated published cases and 16 new observations.

1993 • 75 citations

Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia

1993 • 69 citations

Molecular analysis of t(11;19) breakpoints in childhood acute leukemias

1996 • 64 citations

CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group study

1996 • 37 citations

Childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): an update [letter]

1994 • 27 citations

Rearrangements on chromosome 11q23 in hematopoietic tumor-associated t(11;14) and t(11;19) translocations.

1991 • 21 citations