CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

2003 • 1,267 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion

2004 • 409 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Activation requirements for the induction of CD4⁺CD25⁺ T cell suppressor function

2004 • 307 citations

T cell anergy and costimulation

2003 • 299 citations

Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

2004 • 297 citations

In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures

2004 • 281 citations

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells

2004 • 279 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

CD28 Costimulation Mediates Down-Regulation of p27kip1and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells

2002 • 191 citations

Protein kinase B (Akt) regulation and function in T lymphocytes

2002 • 125 citations

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

2001 • 81 citations

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