A genetic link between co-suppression and RNA interference in C. elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Epigenetics: Regulation Through Repression

1999 • 1,215 citations

Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression.

1990 • 1,182 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance.

1993 • 734 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

RNA-triggered gene silencing

1999 • 623 citations

RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

1998 • 561 citations

gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans.

1995 • 365 citations

MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans

2000 • 308 citations

Transgene‐mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover

1994 • 297 citations

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

1994 • 284 citations

Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68.

1995 • 254 citations

Cosuppression in Drosophila: Gene Silencing of Alcohol dehydrogenase by white-Adh Transgenes Is Polycomb Dependent

1997 • 245 citations

Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans

1999 • 228 citations

An RNA-Based Information Superhighway in Plants

1998 • 225 citations

Taming of transposable elements by homology-dependent gene silencing

1999 • 221 citations

DNA methylation inhibits elongation but not initiation of transcription in Neurospora crassa

1997 • 202 citations

De novomethylation and co-suppression induced by a cytoplasmically replicating plant RNA virus

1998 • 195 citations

Activation of a transposable element in the germ line but not the soma of Caenorhabditis elegans

1987 • 192 citations

Gene Silencing

1999 • 157 citations

Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants

1996 • 141 citations

Analysis of a mutator activity necessary for germline transposition and excision of Tc1 transposable elements in Caenorhabditis elegans.

1988 • 99 citations

Dissecting the Mechanisms of Posttranscriptional Gene Silencing

1999 • 94 citations

Cosuppression of Nonhomologous Transgenes in Drosophila Involves Mutually Related Endogenous Sequences

1999 • 88 citations

Cosuppression Comes to the Animals

1997 • 54 citations

Post-transcriptional regulation of sex determination in Caenorhabditis elegans: widespread expression of the sex-determining gene fem-1 in both sexes.

1996 • 51 citations

Do unintended antisense transcripts contribute to sense cosuppression in plants?

1999 • 32 citations