Evolutionary Conservation of Function Among Mammalian, Avian, and Viral Homologs of the Bcl-2 Oncoprotein

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

DNA sequence and expression of the B95-8 Epstein—Barr virus genome

1984 • 2,039 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

A versatilein vivoandin vitroeukaryotic expression vector for protein engineering

1988 • 686 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

1990 • 447 citations

A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus.

1985 • 445 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin.

1991 • 222 citations

Characterization of translocation contact sites involved in the import of mitochondrial proteins.

1987 • 219 citations

Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma

1987 • 200 citations

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1993 • 185 citations

Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex

1987 • 183 citations

Oncogenic potential of bcl-2 demonstrated by gene transfer

1988 • 180 citations

DNA Sequencing Markets

1990 • 173 citations

Site-directed Mutagenesis of β-Adrenergic Receptors

1989 • 155 citations

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

1990 • 147 citations

Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells.

1993 • 144 citations

Expression and Site-specific Mutagenesis of Phospholamban

1989 • 123 citations

Isolation and characterization of the chickenbcl–2gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo

1992 • 118 citations

The Epstein-Barr Virus Proteins

1988 • 109 citations

Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

1993 • 109 citations

Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.

1992 • 109 citations

Differentiated functions expressed by cultured mouse lymphoma cells

1970 • 91 citations

Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte.

1985 • 80 citations

Prevention of programmed cell death in burkitt lymphoma cell lines by bcl‐2‐dependent and ‐independent mechanisms

1992 • 71 citations

Identification and characterization of glucocorticoid-regulated nuclease(s) in lymphoid cells undergoing apoptosis

1991 • 53 citations

Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein

1992 • 39 citations

IL3-Dependent Cells Die by Apoptosis on Removal of their Growth Factor

1991 • 35 citations

Alteration of growth and differentiation factors response by Kirsten and Harvey sarcoma viruses in the IL-3-dependent murine hematopoietic cell line 32D C13(G).

1989 • 29 citations

Cell cycle analysis of p26-BCL-2 protein levels in proliferating lymphoma and leukemia cell lines.

1992 • 22 citations