Modulating the Bcl-2 Family of Apoptosis Suppressors for Potential Therapeutic Benefit in Cancer

Cell Death

2004 • 4,599 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

Discovering High-Affinity Ligands for Proteins: SAR by NMR

1996 • 1,986 citations

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

2004 • 1,285 citations

A matter of life and death

2002 • 1,251 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Chemistry and Biology of Roseophilin and the Prodigiosin Alkaloids: A Survey of the Last 2500 Years

2003 • 789 citations

Regulation of apoptosis by endoplasmic reticulum pathways

2003 • 718 citations

Apoptosis-based therapies

2002 • 646 citations

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

2002 • 624 citations

Ras signalling and apoptosis

1998 • 559 citations

Oncoprotein Networks

1997 • 532 citations

Apoptosis-targeted therapies for cancer

2003 • 496 citations

Myeloid cell factor–1 is a critical survival factor for multiple myeloma

2002 • 365 citations

Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells

2005 • 327 citations

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis

2005 • 325 citations

Insights into Programmed Cell Death through Structural Biology

2000 • 307 citations

Apoptosis regulators and their role in tumorigenesis

2001 • 239 citations

Differential Regulation of Noxa in Normal Melanocytes and Melanoma Cells by Proteasome Inhibition: Therapeutic Implications

2005 • 225 citations

Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands

2004 • 223 citations

TNF-α Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K

2000 • 196 citations

Nucleosomes in serum of patients with benign and malignant diseases

2001 • 187 citations

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

2004 • 169 citations

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

2003 • 144 citations

During Apoptosis Bcl-2 Changes Membrane Topology at Both the Endoplasmic Reticulum and Mitochondria

2004 • 102 citations

Cell cycle: On target with Myc

1996 • 81 citations

Cellular Distribution of Bcl-2 Family Proteins

2003 • 60 citations

Proteasome Inhibitors in Cancer Therapy

2005 • 29 citations

Therapeutic activation of caspases in cancer: a question of selectivity.

2003 • 28 citations

Cellular Distribution of Bcl-2 Family Proteins

2003 • 12 citations