Nucleosomes in serum of patients with benign and malignant diseases

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Free DNA in the serum of cancer patients and the effect of therapy.

1977 • 1,708 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Structure of Chromatin

1977 • 1,276 citations

Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)

1997 • 1,082 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Radiation-induced apoptosis: Relevance to radiotherapy

1995 • 504 citations

Soluble normal and mutated DNA sequences from single-copy genes in human blood.

1994 • 478 citations

Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients.

1999 • 450 citations

Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease

1983 • 398 citations

The Origin and Mechanism of Circulating DNA

2000 • 370 citations

Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone.

1990 • 367 citations

Chapter 2 Assays of Cell Viability: Discrimination of Cells Dying by Apoptosis

1994 • 354 citations

Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours

1995 • 258 citations

Apoptosis Biochemical events and relevance to cancer chemotherapy

1992 • 238 citations

Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells.

1990 • 216 citations

Heterogeneity in the Development of Apoptosis in Irradiated Murine Tumours of Different Histologies

1993 • 203 citations

Detecting tumor-related alterations in plasma or serum DNA of patients diagnosed with breast cancer.

1999 • 193 citations

Apoptosis and chemotherapy resistance

1996 • 183 citations

Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus. Correlation with serum antinucleosome antibody titers and absence of clear association with disease activity

1997 • 182 citations

Blood clearance kinetics and liver uptake of mononucleosomes in mice.

1996 • 165 citations

Free DNA in serum and plasma from normal adults.

1975 • 165 citations

Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.

1998 • 159 citations

Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response

1997 • 156 citations

Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosis.

1999 • 142 citations

Microsatellite analysis of plasma DNA from patients with clear cell renal carcinoma.

1998 • 136 citations

Somatic Mutation Screening: Identification of Individuals Harboring K-ras Mutations With the Use of Plasma DNA

2000 • 132 citations

An Overview on the Isolation and Analysis of Circulating Tumor DNA in Plasma and Serum

2000 • 122 citations

Development of apoptosis in irradiated murine tumors as a function of time and dose.

1993 • 117 citations

Apoptosis in murine tumors treated with chemotherapy agents

1995 • 115 citations

Circulating DNA and lupus nephritis

1988 • 103 citations

Microsatellite alterations plasma DNA of primary breast cancer patients.

2000 • 100 citations

Nucleosomes occurring in protein‐free hybridoma cell culture Evidence for programmed cell death

1991 • 98 citations

Haemodialysis as a model for studying endogenous plasma DNA: oligonucleosome-like structure and clearance

1992 • 93 citations

Detection of plasma tumor DNA in head and neck squamous cell carcinoma by microsatellite typing and p53 mutation analysis.

2000 • 91 citations

Development of Apoptosis in Irradiated Murine Tumors as a Function of Time and Dose

1993 • 80 citations

A smoking cessation intervention for head and neck cancer patients: trial design, patient accrual, and characteristics.

1991 • 73 citations

The effect of acute phase proteins on clearance of chromatin from the circulation of normal mice.

1996 • 69 citations

Death from inside out: an overview

1994 • 69 citations

Apoptosis and response to radiation: implications for radiation therapy.

1997 • 65 citations

Regulation of nuclear antigen expression on the cell surface of human monocytes.

1992 • 64 citations

Cell death in the third millennium

2000 • 63 citations

Induction of apoptosis in murine tumors by cyclophosphamide

1994 • 61 citations

Detection of Microsatellite Alterations in the DNA Isolated from Tumor Cells and from Plasma DNA of Patients with Lung Cancer

2000 • 55 citations

[Plasma DNA level as a tumor marker in primary lung cancer].

1990 • 51 citations

Radiation-induced apoptosis in a murine lymphoma in vivo

1994 • 48 citations

Biochemical Modulation of Radiation-Induced Apoptosis in Murine Lymphoma Cells

1993 • 48 citations

Circulating DNA: What We Know and What We Need to Learn

2000 • 40 citations

Reemergence of apoptotic cells between fractionated doses in irradiated murine tumors

1994 • 39 citations

The immunological potential of apoptotic debris produced by tumor cells and during HIV infection

1994 • 38 citations

Accelerated repopulation during fractionated irradiation of a murine ovarian carcinoma: Downregulation of apoptosis as a possible mechanism

1996 • 38 citations

Quantitative Aspects of Plasma/Serum DNA in Cancer Patients

2000 • 36 citations

Microsatellite abnormalities in plasma of patients with breast carcinoma: concordance with the primary tumour.

1999 • 33 citations

Perspective: The Chemotherapeutic Relevance of Apoptosis and a Proposed Biochemical Cascade for Chemotherapeutically Induced Apoptosis

1997 • 27 citations

Clinical Significance of Circulating DNA Microsatellite Markers in Plasma of Melanoma Patients

2000 • 25 citations

Plasma DNA K‐ras Mutations in Patients with Gastrointestinal Malignancies

2000 • 24 citations

Programmed cell death (apoptosis) in immunity and haematological neoplasia.

1993 • 20 citations

[Characteristics of plasma DNA and its application for detection of K-ras gene mutation].

2000 • 3 citations

Deleted Work

1955 • 0 citations