Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors.
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References (81)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
1970 • 253,849 citations
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 • 47,043 citations
Calcium's Role in Mechanotransduction during Muscle Development
2014 • 14,293 citations
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 • 9,986 citations
Integrins and Signal Transduction Pathways: the Road Taken
1995 • 3,002 citations
Mechanotransduction Across the Cell Surface and Through the Cytoskeleton
1993 • 2,947 citations
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
1988 • 2,137 citations
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.
1979 • 2,025 citations
Integrins and other cell adhesion molecules
1990 • 1,990 citations
Signal transduction from the extracellular matrix.
1993 • 1,727 citations
VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes
1990 • 1,592 citations
How does the extracellular matrix direct gene expression?
1982 • 1,475 citations
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.
1992 • 1,456 citations
Integrins.
1991 • 1,369 citations
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.
1992 • 1,330 citations
Fibroblast traction as a mechanism for collagen morphogenesis
1981 • 862 citations
Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
1992 • 831 citations
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.
1992 • 811 citations
Integrins as mechanochemical transducers
1991 • 684 citations
Signal Transduction by the Platelet-Derived Growth Factor Receptor
1989 • 653 citations
Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors
1989 • 633 citations
The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells.
1990 • 629 citations
Platelet-derived growth factor receptor signals.
1994 • 561 citations
Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information
1992 • 532 citations
Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.
1988 • 514 citations
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
1994 • 450 citations
The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.
1988 • 446 citations
Inside-out integrin signalling
1992 • 439 citations
Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.
1995 • 415 citations
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.
1994 • 414 citations
Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells
1991 • 379 citations
Integrin alpha 2 beta 1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils.
1991 • 354 citations
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.
1988 • 338 citations
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.
1993 • 335 citations
Rapid methods for isolation of human plasma fibronectin
1982 • 313 citations
Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.
1994 • 305 citations
Studies on the mechanism of hydrated collagen gel reorganization by human skin fibroblasts
1985 • 278 citations
Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin.
1986 • 270 citations
β1 Integrin-mediated collagen gel contraction is stimulated by PDGF
1990 • 266 citations
PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.
1992 • 259 citations
Monoclonal antibodies to phosphotyrosine
1988 • 242 citations
Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.
1995 • 237 citations
Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices.
1989 • 224 citations
Transmembrane signalling by integrins
1992 • 219 citations
Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers
1988 • 218 citations
Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis
1991 • 217 citations
Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus
1985 • 205 citations
Integrating with integrins.
1994 • 189 citations
alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.
1994 • 186 citations
Analysis of the role of microfilaments and microtubules in acquisition of bipolarity and elongation of fibroblasts in hydrated collagen gels.
1984 • 177 citations
Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.
1991 • 166 citations
Paxillin: A cytoskeletal target for tyrosine kinases
1994 • 162 citations
Hierarchy of Binding Sites for Grb2 and Shc on the Epidermal Growth Factor Receptor
1994 • 159 citations
Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor
1988 • 156 citations
Dynamic expression of alpha 1 beta 1 and alpha 2 beta 1 integrin receptors by human vascular smooth muscle cells. Alpha 2 beta 1 integrin is required for chemotaxis across type I collagen-coated membranes.
1994 • 148 citations
Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation.
1988 • 147 citations
Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 α and transforming growth factor-β1
1992 • 142 citations
Expression of Three Recombinant Homodimeric Isoforms of PDGF inSaccharomyces cerevisiae: Evidence for Difference in Receptor Binding and Functional Activities
1989 • 126 citations
Identification of Integrin-like Matrix Receptors with Affinity for Interstitial Collagens
1989 • 123 citations
Integrin-Mediated Collagen Matrix Reorganization by Cultured Human Vascular Smooth Muscle Cells
1995 • 122 citations
Focal Adhesions: Transmembrane Junctions Between The Extracellular Matrix And The Cytoskeleton
1988 • 117 citations
Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices
1993 • 105 citations
Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody.
1987 • 102 citations
Suramin: prototype of a new generation of antitumor compounds.
1990 • 101 citations
VLA Proteins In The Integrin Family: Structures, Functions, And Their Role On Leukocytes
1990 • 90 citations
Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor.
1992 • 87 citations
Going with the flow
1988 • 78 citations
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.
1990 • 77 citations
cDNA Cloning and Expression of a Human Platelet-Derived Growth Factor (PDGF) Receptor Specific for B-Chain-Containing PDGF Molecules
1988 • 76 citations
Characterization of platelet-derived growth factor beta-receptor expressing cells in the vasculature of human rheumatoid synovium.
1991 • 72 citations
Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor.
1988 • 68 citations
Phorbol 12-myristate 13-acetate inhibits granulocyte-macrophage colony stimulating factor-induced protein tyrosine phosphorylation in a human factor-dependent hematopoietic cell line.
1991 • 67 citations
Radioimmunoassay of human platelet-derived growth factor using monoclonal antibody toward a synthetic 73–97 fragment of its B-chain
1989 • 55 citations
Signal transduction from the extracellular matrix: the integrin-tyrosine kinase connection
1992 • 53 citations
Cellular responses to extracellular matrix
1992 • 49 citations
Hepatocyte adhesion to collagen
1986 • 42 citations
Platelet-Derived Growth Factor-BB Stimulates Synthesis of the Integrin α2-Subunit in Human Diploid Fibroblasts
1994 • 39 citations
Identification of the cellular mechanisms responsible for platelet‐derived growth factor induced alterations in cytoplasmic vinculin distribution
1986 • 39 citations
Expression of platelet-derived growth factor-beta receptors on human fibroblasts. Regulation by recombinant platelet-derived growth factor-BB, IL-1, and tumor necrosis factor-alpha.
1992 • 30 citations
Signal Transduction by the Platelet-derived Growth Factor Receptor
1988 • 28 citations
Signal transduction by integrin receptors for extracellular matrix: Cooperative processing of extracellular information
1992 • 26 citations