An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region

1985 • 1,244 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

1991 • 618 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

1991 • 517 citations

Positive autoregulation of the myogenic determination gene MyoD1

1989 • 492 citations

The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain

1989 • 490 citations

COUP transcription factor is a member of the steroid receptor superfamily

1989 • 480 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

A transcriptional hierarchy involved in mammalian cell-type specification

1992 • 428 citations

The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

1986 • 406 citations

Homeobox proteins as sequence-specific transcription factors

1988 • 397 citations

cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

1991 • 388 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.

1991 • 333 citations

Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.

1992 • 325 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro.

1991 • 307 citations

Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells

1989 • 291 citations

HNF-1, a member of a novel class of dimerizing homeodomain proteins.

1991 • 286 citations

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.

1992 • 279 citations

vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1.

1991 • 276 citations

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

1990 • 264 citations

A glycosylated liver-specific transcription factor stimulates transcription of the albumin gene

1989 • 244 citations

Mitotic Phosphorylation of the Oct-1 Homeodomain and Regulation of Oct-1 DNA Binding Activity

1991 • 237 citations

Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter.

1988 • 236 citations

Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements

1990 • 224 citations

A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways.

1991 • 217 citations

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.

1991 • 210 citations

Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements

1991 • 206 citations

Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4.

1991 • 192 citations

The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription.

1991 • 188 citations

LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia.

1991 • 171 citations

A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1

1990 • 157 citations

Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles

1992 • 150 citations

Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1.

1990 • 139 citations

A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain

1990 • 133 citations

Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells

1989 • 129 citations

Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells.

1991 • 128 citations

Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites.

1991 • 112 citations

Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.

1990 • 110 citations

Two members of an HNF1 homeoprotein family are expressed in human liver

1991 • 105 citations

The Restricted Promoter Activity of the Liver Transcription Factor Hepatocyte Nuclear Factor 3β Involves a Cell-Specific Factor and Positive Autoactivation

1992 • 98 citations

An autoregulatory enhancer element of the Drosophila homeotic gene Deformed.

1990 • 96 citations

Analysis of the rat hepatocyte nuclear factor (HNF) 1 gene promoter: synergistic activation by HNF4 and HNF1 proteins

1993 • 76 citations

Antagonism between Apolipoprotein AI Regulatory Protein 1, Ear3/COUP-TF, and Hepatocyte Nuclear Factor 4 Modulates Apolipoprotein CIII Gene Expression in Liver and Intestinal Cells

1992 • 71 citations

In vitro activity of the transcription activation functions of the progesterone receptor. Evidence for intermediary factors.

1992 • 59 citations

Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells.

1991 • 46 citations

NOTES: A Retinoic Acid-Responsive Element in the Apolipoprotein AI Gene Distinguishes between Two Different Retinoic Acid Response Pathways

1991 • 40 citations

Synergistic Interactions between Transcription Factors Control Expression of the Apolipoprotein AI Gene in Liver Cells

1991 • 32 citations

Purification and characterization of a heat stable nuclear factor CIIIB1 involved in the regulation of the human ApoC-III gene

1991 • 30 citations

Regulation of albumin gene expression in hepatoma cells of fetal phenotype: dominant inhibition of HNF1 function and role of ubiquitous transcription factors.

1993 • 26 citations