Radiation-induced G1 arrest is selectively mediated by the p53-WAF1/Cip1 pathway in human thyroid cells.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

1993 • 652 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

1993 • 309 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

Thyroid cancer in childhood and adolescence.A report on twenty-eight cases

1950 • 227 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

Ionizing irradiation and the induction of clinically significant disease in the human thyroid gland

1977 • 213 citations

Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.

1990 • 134 citations

Characterization of a human follicular thyroid carcinoma cell line (UCLA RO 82 W-1)

1989 • 112 citations

Interleukin-1 Production and Action in Thyroid Tissue

1989 • 67 citations

Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters.

1993 • 54 citations

Overexpression of the intact thyrotropin receptor in a human thyroid carcinoma cell line.

1993 • 12 citations

Anaplastic carcinoma of thyroid: radiation-associated.

1979 • 6 citations