Aberrant Activation of the Androgen Receptor by NF-κB2/p52 in Prostate Cancer Cells

Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth

2008 • 1,390 citations

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

2008 • 1,044 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

2008 • 808 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer.

2001 • 755 citations

The Androgen Axis in Recurrent Prostate Cancer

2004 • 679 citations

HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

2000 • 460 citations

Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

2000 • 451 citations

CD40 regulates the processing of NF-kappaB2 p100 to p52

2002 • 435 citations

Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor.

1998 • 433 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer

2003 • 424 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

1996 • 393 citations

Androgen receptors in endocrine‐therapy‐resistant human prostate cancer

1991 • 390 citations

Distant metastases from prostatic carcinoma express androgen receptor protein.

1995 • 282 citations

Induction of p100 Processing by NF-κB-inducing Kinase Involves Docking IκB Kinase α (IKKα) to p100 and IKKα-mediated Phosphorylation

2004 • 280 citations

Androgen-independent Induction of Prostate-specific Antigen Gene Expression via Cross-talk between the Androgen Receptor and Protein Kinase A Signal Transduction Pathways

1999 • 273 citations

From estrogen to androgen receptor: A new pathway for sex hormones in prostate

1998 • 272 citations

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.

2000 • 256 citations

Mutual Transcriptional Interference between RelA and Androgen Receptor

1996 • 217 citations

Mitogen-Activated Protein Kinase Kinase Kinase 1 Activates Androgen Receptor-Dependent Transcription and Apoptosis in Prostate Cancer

1999 • 211 citations

NF-κB Activates Prostate-Specific Antigen Expression and Is Upregulated in Androgen-Independent Prostate Cancer

2002 • 178 citations

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

1997 • 178 citations

The Nuclear Factor-κB Pathway Controls the Progression of Prostate Cancer to Androgen-Independent Growth

2008 • 177 citations

NF-κB Regulates Androgen Receptor Expression and Prostate Cancer Growth

2009 • 172 citations

Alternative pathways of NF-κB activation: A double-edged sword in health and disease

2006 • 142 citations

Stat3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation

2006 • 130 citations

Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications

2008 • 126 citations

The Corepressors Silencing Mediator of Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Are Involved in Agonist- and Antagonist-Regulated Transcription by Androgen Receptor

2005 • 125 citations

Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells

2009 • 100 citations

Interleukin‐6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression

2007 • 87 citations

Nuclear Localization of Nuclear Factor-κB p65 in Primary Prostate Tumors Is Highly Predictive of Pelvic Lymph Node Metastases

2006 • 79 citations

Stat3 enhances transactivation of steroid hormone receptors.

2003 • 72 citations

Aberrant Activation of Androgen Receptor in a New Neuropeptide-Autocrine Model of Androgen-Insensitive Prostate Cancer

2008 • 70 citations

Prostate Tissue Androgens: History and Current Clinical Relevance

2008 • 65 citations

Inappropriate Activation of the Androgen Receptor by Nonsteroids: Involvement of the Src Kinase Pathway and Its Therapeutic Implications

2006 • 62 citations

Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice

2002 • 53 citations

Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer

2006 • 52 citations

A Transgenic Model Reveals Important Roles for the NF-κB Alternative Pathway (p100/p52) in Mammary Development and Links to Tumorigenesis

2007 • 51 citations

Essential Role of IκB Kinase α in the Constitutive Processing of NF-κB2 p100

2005 • 51 citations

Regulation of NF-κB2 p100 Processing by Its cis-Acting Domain

2004 • 50 citations

NF‐κB2/p52 enhances androgen‐independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen‐deprivation

2008 • 49 citations

Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells

2004 • 38 citations

Microarray analysis reveals potential target genes of NF‐κB2/p52 in LNCaP prostate cancer cells

2009 • 35 citations