Sodium-Calcium Exchange: A Molecular Perspective
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Abstract
References (110)
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Sodium/Calcium Exchange: Its Physiological Implications
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Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure.
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Calcineurin Inhibits VCX1-Dependent H+/Ca2+ Exchange and Induces Ca2+ ATPases in Saccharomyces cerevisiae
1996 • 431 citations
Tissue specificity and alternative splicing of the Na+/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat
1997 • 409 citations
Upregulation of Na + /Ca 2+ Exchanger Expression and Function in an Arrhythmogenic Rabbit Model of Heart Failure
1999 • 396 citations
Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger
1994 • 353 citations
Cloning of a Third Mammalian Na+-Ca2+ Exchanger, NCX3
1996 • 347 citations
Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, I
1999 • 328 citations
Regulation and deregulation of cardiac Na+–Ca2+ exchange in giant excised sarcolemmal membrane patches
1990 • 320 citations
Na + pump low and high ouabain affinity α subunit isoforms are differently distributed in cells
1997 • 299 citations
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation.
1992 • 295 citations
Initial localization of regulatory regions of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
1993 • 290 citations
CAX1, an H+/Ca2+ antiporter from Arabidopsis.
1996 • 282 citations
Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
1991 • 277 citations
The Relationship Between Charge Movements Associated with I Ca and I Na-Ca in Cardiac Myocyte
1990 • 267 citations
Evidence for Functional Relevance of an Enhanced Expression of the Na + -Ca 2+ Exchanger in Failing Human Myocardium
1996 • 253 citations
Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms.
1994 • 246 citations
Regulation of the cardiac Na(+)-Ca2+ exchanger by Ca2+. Mutational analysis of the Ca(2+)-binding domain.
1995 • 239 citations
Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger.
1994 • 235 citations
Charge movement during Na+ translocation by native and cloned cardiac Na+/Ca2+ exchanger
1991 • 221 citations
Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3)
1998 • 219 citations
Sodium-calcium exchange current. Dependence on internal Ca and Na and competitive binding of external Na and Ca.
1989 • 215 citations
Primary structure and functional expression of the Na/Ca,K-exchanger from bovine rod photoreceptors.
1992 • 203 citations
Effects of Overexpression of the Na + -Ca 2+ Exchanger on [Ca 2+ ] i Transients in Murine Ventricular Myocytes
1998 • 200 citations
Calx, a Na-Ca exchanger gene ofDrosophila melanogaster
1997 • 197 citations
A New Topological Model of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger
1999 • 196 citations
Low Efficiency of Ca 2+ Entry Through the Na + -Ca 2+ Exchanger as Trigger for Ca 2+ Release From the Sarcoplasmic Reticulum
1997 • 194 citations
Identification of the high affinity Ca(2+)-binding domain of the cardiac Na(+)-Ca2+ exchanger.
1994 • 193 citations
Kinetics, stoichiometry and role of the Na–Ca exchange mechanism in isolated cardiac myocytes
1990 • 192 citations
Purification of the cardiac Na+Ca2+ exchange protein
1988 • 191 citations
Cloning and characterization of a putative Ca2+/H+ antiporter gene from Escherichia coli upon functional complementation of Na+/H+ antiporter-deficient strains by the overexpressed gene
1993 • 190 citations
Phosphorylation-dependent Regulation of Cardiac Na+/Ca2+ Exchanger via Protein Kinase C
1996 • 190 citations
Overexpression of the Cardiac Na + /Ca 2+ Exchanger Increases Susceptibility to Ischemia/Reperfusion Injury in Male, but Not Female, Transgenic Mice
1998 • 187 citations
Sodium current‐induced calcium signals in isolated guinea‐pig ventricular myocytes.
1994 • 184 citations
Regulation of the Cardiac Na+-Ca2+ Exchanger by the Endogenous XIP Region
1997 • 175 citations
Na+-Ca2+ exchange in bovine rod outer segments requires and transports K+
1989 • 172 citations
Na-Ca Exchange and the Trigger for Sarcoplasmic Reticulum Ca Release: Studies in Adult Rabbit Ventricular Myocytes
1998 • 172 citations
The Sarcoplasmic Reticulum and the Na + /Ca 2+ Exchanger Both Contribute to the Ca 2+ Transient of Failing Human Ventricular Myocytes
1999 • 164 citations
Ca 2+ Flux Through Promiscuous Cardiac Na + Channels: Slip-Mode Conductance
1998 • 163 citations
Differential inhibition of Na+/Ca2+exchanger isoforms by divalent cations and isothiourea derivative
1998 • 160 citations
Calcium influx in internally dialyzed squid giant axons.
1979 • 158 citations
Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes
1996 • 153 citations
Gating of the Cardiac Ca 2+ Release Channel: the Role of Na + Current and Na + -Ca 2+ Exchange
1992 • 150 citations
Mutation of Amino Acid Residues in the Putative Transmembrane Segments of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger
1996 • 150 citations
Na+−Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+−Ca2+ exchanger
1998 • 148 citations
Cardiac Na+/Ca2+ exchange activity in patients with end-stage heart failure
1996 • 148 citations
The Product of HUM1, a Novel Yeast Gene, Is Required for Vacuolar Ca2+/H+ Exchange and Is Related to Mammalian Na+/Ca2+ Exchangers
1996 • 143 citations
The Cellular Mechanism of Action of Cardiotonic Steroids: A New Hypothesis
1998 • 138 citations
Steady-state twitch Ca2+ fluxes and cytosolic Ca2+ buffering in rabbit ventricular myocytes
1996 • 135 citations
Intracellular Ca2+ transients during rapid cooling contractures in guinea‐pig ventricular myocytes.
1989 • 134 citations
Calcium Signaling in Transgenic Mice Overexpressing Cardiac Na+-Ca2+ Exchanger
1997 • 125 citations
Molecular Cloning of a Novel Potassium-dependent Sodium-Calcium Exchanger from Rat Brain
1998 • 124 citations
Protein Kinase C-Dependent Regulation of Na+/Ca2+ Exchanger Isoforms NCX1 and NCX3 Does Not Require Their Direct Phosphorylation
1998 • 109 citations
The role of Na(+)‐Ca2+ exchange in activation of excitation‐contraction coupling in rat ventricular myocytes.
1996 • 107 citations
Expressional analysis of the cardiac Na–Ca exchanger in rat development and senescence
1998 • 100 citations
Rapid expression of the Na(+)-Ca2+ exchanger in response to cardiac pressure overload
1993 • 96 citations
A Circularized Sodium-Calcium Exchanger Exon 2 Transcript
1999 • 96 citations
Reciprocal changes in the postnatal expression of the sarcolemmal Na+-Ca2+-exchanger and SERCA2 in rat heart
1995 • 93 citations
The role of sarcolemmal Ca2+‐ATPase in the regulation of resting calcium concentration in rat ventricular myocytes
1999 • 88 citations
Distinction between the two basic mechanisms of cation transport in the cardiac sodium-calcium exchange system
1990 • 86 citations
Na+/Ca2+ exchange current density in cardiac myocytes from rabbits and guinea pigs during postnatal development
1995 • 85 citations
Growth Factor-induced Phosphorylation and Activation of Aortic Smooth Muscle Na+/Ca2+Exchanger
1995 • 85 citations
Anomalous regulation of the Drosophila Na(+)-Ca2+ exchanger by Ca2+.
1996 • 84 citations
Isoform-Specific Regulation of the Na+/Ca2+Exchanger in Rat Astrocytes and Neurons by PKA
1998 • 82 citations
Biosynthesis and initial processing of the cardiac sarcolemmal Na+-Ca2+ exchanger
1993 • 81 citations
Purification and amino-terminal sequence of the bovine cardiac sodium-calcium exchanger: Evidence for the presence of a signal sequence
1991 • 79 citations
Topology of a Functionally Important Region of the Cardiac Na+/Ca2+ Exchanger
1998 • 79 citations
Regulation of Na ‐ Ca Exchange
1991 • 76 citations
Interaction of the Na+‐K+ pump and Na+‐Ca2+ exchange via [Na+]i in a restricted space of guinea‐pig ventricular cells
1998 • 73 citations
Unitary cardiac Na+, Ca2+ exchange current magnitudes determined from channel-like noise and charge movements of ion transport
1996 • 73 citations
Cloning of Cardiac, Kidney, and Brain Promoters of the Feline ncx1 Gene
1997 • 65 citations
Cloning, Expression, and Characterization of the Squid Na+–Ca2+ Exchanger (NCX-SQ1)
1998 • 56 citations
Influence of prior Na+pump activity on pump and Na+/Ca2+exchange currents in mouse ventricular myocytes
1998 • 53 citations
Alternative promoters and cardiac muscle cell-specific expression of the Na+/Ca2+exchanger gene
1998 • 51 citations
Functional Differences in Ionic Regulation between Alternatively Spliced Isoforms of the Na+-Ca2+ Exchanger from Drosophila melanogaster
1998 • 51 citations
Regulation of cardiac sodium-calcium exchanger by beta-adrenergic agonists.
1996 • 51 citations
Regulation of Na+/Ca2+exchange activity by cytosolic Ca2+in transfected Chinese hamster ovary cells
1998 • 50 citations
The Organization of the Human Gene NCX1 Encoding the Sodium–Calcium Exchanger
1996 • 50 citations
Contribution of Na/Ca exchange to Ca2+ outflow and entry in the rat pancreatic beta-cell: studies with antisense oligonucleotides.
1998 • 48 citations
Rapid charge translocation by the cardiac Na(+)-Ca2+ exchanger after a Ca2+ concentration jump
1996 • 47 citations
Membrane topology of the rat brain Na+–Ca2+ exchanger
1998 • 46 citations
Structure-Function Analysis of CALX1.1, a Na+-Ca2+ Exchanger fromDrosophila
1998 • 45 citations
Physiological effects of Na+/Ca2+exchanger knockdown by antisense oligodeoxynucleotides in arterial myocytes
1998 • 44 citations
Na+/Ca2+ exchange and cellular Ca2+ homeostasis.
1998 • 43 citations
Cardiac expression of the Na+/Ca2+exchanger NCX1 is GATA factor dependent
1999 • 43 citations
Specific inhibition of Na‐Ca exchange function by antisense oligodeoxynucleotides
1995 • 40 citations
Na+/Ca2+ exchange current and contractions measured under Cl(-)-free conditions in developing rabbit hearts
1997 • 38 citations
A novel 13 kDa cytoplasmic soluble protein is required for the nucleotide (MgATP) modulation of the Na/Ca exchange in squid nerve fibers
1997 • 37 citations
Na+/Ca2+exchange in neonatal rat heart cells: antisense inhibition and protein half-life
1998 • 33 citations
Evidence That Reverse Na‐Ca Exchange Can Trigger SR Calcium Releasea
1996 • 33 citations
The Cleaved N-Terminal Signal Sequence of the Cardiac Na+-Ca2+ Exchanger Is Not Required for Functional Membrane Integration
1995 • 31 citations
The Putative Amino-terminal Signal Peptide of the Cloned Rat Brain Na+-Ca2+ Exchanger Gene (RBE-1) Is Not Mandatory for Functional Expression
1995 • 30 citations
A Novel Molecular Determinant for cAMP-dependent Regulation of the Frog Heart Na+-Ca2+Exchanger
1998 • 26 citations
NCX1 Na/Ca exchanger inhibition by antisense oligonucleotides in mouse distal convoluted tubule cells
1998 • 26 citations
Expression of a Functionally Active Human Renal Sodium-Calcium Exchanger Lacking a Signal Sequence
1995 • 24 citations
The 70 kD component of the heart sarcolemmal Na+/Ca2+-exchanger preparation is the C-terminal portion of the protein
1995 • 24 citations
Expression of an Active Na+/Ca2+ Exchanger Isoform Lacking the Six C‐Terminal Transmembrane Segments
1996 • 23 citations
Subcellular Distribution of Ankyrin in Developing Rabbit Heart—Relationship to the Na+–Ca2+Exchanger
1997 • 20 citations
Cardiac Na+/Ca2+ exchange activity in patients with end-stage heart failure
1996 • 16 citations
Differential up‐regulation of Na+‐Ca2+ exchange by phosphoarginine and ATP in dialysed squid axons
1998 • 15 citations
Deleted Work
1955 • 0 citations