Salmonella typhimurium induces epithelial IL-8 expression via Ca2+-mediated activation of the NF-κB pathway

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells

1997 • 1,168 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Mg2+ as an Extracellular Signal: Environmental Regulation of Salmonella Virulence

1996 • 817 citations

S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

1998 • 804 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry

1993 • 663 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene,mdr1a, Spontaneously Develop Colitis

1998 • 570 citations

The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells

1997 • 564 citations

Regulation of Lipid A Modifications by Salmonella typhimurium Virulence Genes phoP-phoQ

1997 • 553 citations

Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium.

1967 • 532 citations

Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8.

1989 • 515 citations

NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter

1993 • 504 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Molecular mechanism of interleukin-8 gene expression

1994 • 465 citations

Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils.

1993 • 460 citations

SopB, a protein required for virulence of Salmonella dublin , is an inositol phosphate phosphatase

1998 • 436 citations

Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells.

1997 • 410 citations

Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages

1990 • 399 citations

NF-kappa B subunit-specific regulation of the interleukin-8 promoter.

1993 • 369 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes

1995 • 350 citations

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.

1994 • 327 citations

Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells.

1998 • 310 citations

Endothelial Interferon Regulatory Factor 1 Cooperates with NF-κB as a Transcriptional Activator of Vascular Cell Adhesion Molecule 1

1995 • 301 citations

Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation.

1994 • 282 citations

Pro-inflammatory signaling: Last pieces in the NF-κB puzzle?

1998 • 280 citations

Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.

1996 • 280 citations

Signal transduction and invasion of epithelial cells by S. typhimurium

1993 • 260 citations

Activation of NF-κB in intestinal epithelial cells by enteropathogenic Escherichia coli

1997 • 258 citations

SopE, a secreted protein of Salmonelladublin, is translocated into the target eukaryotic cell via a sip‐dependent mechanism and promotes bacterial entry

1996 • 240 citations

Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils.

1995 • 237 citations

Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases

1999 • 192 citations

The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells.

1997 • 192 citations

Transepithelial signaling to neutrophils by salmonellae: a novel virulence mechanism for gastroenteritis

1995 • 189 citations

[24] Established intestinal cell lines as model systems for electrolyte transport studies

1990 • 188 citations

Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus

1998 • 172 citations

Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention.

1996 • 168 citations

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.

1998 • 162 citations

Elevation of intracellular free calcium levels in HEp-2 cells infected with enteropathogenic Escherichia coli

1991 • 160 citations

Warner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier.

1990 • 154 citations

PhoP/PhoQ: macrophage‐specific modulators of Salmonella virulence?

1991 • 137 citations

Inhibition of TNF- α -induced NF- κ B Activation and IL-8 Release in A549 Cells with the Proteasome Inhibitor MG-132

1998 • 122 citations

A diarrheal pathogen, enteropathogenic Escherichia coli (EPEC), triggers a flux of inositol phosphates in infected epithelial cells.

1994 • 117 citations

Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol.

1992 • 105 citations

Orchestration of Neutrophil Movement by Intestinal Epithelial Cells in Response toSalmonella typhimuriumCan Be Uncoupled from Bacterial Internalization

1999 • 101 citations

Salmonella typhimuriuminduces an inositol phosphate flux in infected epithelial cells

1992 • 83 citations

Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation of intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate.

1992 • 82 citations

TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells.

1999 • 77 citations

Differential Effects of Lipopolysaccharide and Tumor Necrosis Factor on Monocytic IκB Kinase Signalsome Activation and IκB Proteolysis

1999 • 70 citations

TNF Receptor-Associated Factor-2 Is Involved in Both IL-1β and TNF-α Signaling Cascades Leading to NF-κB Activation and IL-8 Expression in Human Intestinal Epithelial Cells

1999 • 67 citations

Pasteurella haemolyticaleukotoxin and endotoxin induced cytokine gene expression in bovine alveolar macrophages requires NF-κB activation and calcium elevation

1999 • 63 citations

Bacterial Invasion Is Not Required for Activation of NF-κB in Enterocytes

1999 • 63 citations

Intestinal Interleukin-8 Concentration and Gene Expression in Inflammatory Bowel Disease

1997 • 61 citations

Activation of T84 cell chloride channels by carbachol involves a phosphoinositide-coupled muscarinic M3 receptor

1992 • 55 citations

Global systems approach to bacterial physiology: protein responders to stress and starvation

1990 • 54 citations

Carbachol-activated calcium entry into HT-29 cells is regulated by both membrane potential and cell volume.

1992 • 48 citations

Differential roles of Fc gamma RII and Fc gamma RIII in immune complex stimulation of human neutrophils.

1992 • 47 citations

Study of cytokines in ulcerative colitis.

1995 • 47 citations

Activation of NF-κB in Normal Rat Kidney Epithelial (NRK52E) Cells Is Mediated via a Redox-Insensitive, Calcium-Dependent Pathway

1999 • 42 citations

A cytosolic calcium transient is not necessary for degranulation or oxidative burst in immune complex-stimulated neutrophils

1997 • 25 citations

Role of the FcγR subclasses FcγRII and FcγRIII in the activation of human neutrophils by low and high valency immune complexes

1995 • 24 citations

Epithelial crosstalk with bacteria and immune cells

1998 • 20 citations

Chloride channels and anion fluxes in a human colonic epithelium (HCA‐7)

1992 • 17 citations

New insights on molecular pathways utilized by salmonella species in cell binding

1996 • 7 citations