Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Principles of biochemistry

1978 • 5,242 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Perturbation of vesicular traffic with the carboxylic ionophore monensin

1983 • 890 citations

Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport

1986 • 879 citations

[65] Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods

1969 • 872 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

The rate of bulk flow from the endoplasmic reticulum to the cell surface

1987 • 542 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins

1989 • 466 citations

Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates

1983 • 436 citations

Regulation of Protein Export From the Endoplasmic Reticulum

1988 • 421 citations

Perturbation of cellular calcium induces secretion of luminal ER proteins

1989 • 370 citations

Defective co-translational formation of disulphide bonds in protein disulphide-isomerase-deficient microsomes

1988 • 330 citations

Transport of secretory and membrane glycoproteins from the rough endoplasmic reticulum to the Golgi. A rate-limiting step in protein maturation and secretion.

1988 • 327 citations

Subcellular organization of glycosylation in mammalian cells

1987 • 271 citations

Optimizing hydrolysis of N-linked high-mannose oligosaccharides by endo-β-N-acetylglucosaminidase H

1984 • 270 citations

Glucose removal from N-linked oligosaccharides is required for efficient maturation of certain secretory glycoproteins from the rough endoplasmic reticulum to the Golgi complex.

1984 • 242 citations

Perturbation of cellular calcium blocks exit of secretory proteins from the rough endoplasmic reticulum.

1990 • 229 citations

Relationship of thyrotropin-releasing hormone-induced spike and plateau phases in cytosolic free Ca2+ concentrations to hormone secretion. Selective blockade using ionomycin and nifedipine.

1984 • 226 citations

Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro

1988 • 219 citations

Calcium-Dependent Regulation of Protein Synthesis in Intact Mammalian Cells

1990 • 198 citations

Biochemistry of Interorganelle Transport

1989 • 176 citations

Reduction of Endogenous GRP78 Levels Improves Secretion of a Heterologous Protein in CHO Cells

1988 • 152 citations

Depletion of cellular calcium accelerates protein degradation in the endoplasmic reticulum

1991 • 105 citations

Identification of a Ca2+ requirement for protein synthesis in eukaryotic cells.

1983 • 101 citations

Isolation of a vesicular intermediate in the cell-free transfer of membrane from transitional elements of the endoplasmic reticulum to Golgi apparatus cisternae of rat liver.

1988 • 82 citations

Biosynthesis and Processing of a Human Precursor Complement Protein, pro-C3, in a Hepatoma-Derived Cell Line

1982 • 68 citations

Inhibition of Translational Initiation in Eukaryotic Cells by Calcium Ionophore

1989 • 64 citations

Ionomycin acts as an ionophore to release TRH-regulated Ca2+ stores from GH4C1 cells

1986 • 64 citations

Accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium. A putative role for GRP78

1990 • 59 citations

Biosynthesis and Secretion of α₁‐Antitrypsin in Primary Cultures of Rat Hepatocytes

1982 • 51 citations

The biosynthesis of rat alpha 1-antitrypsin.

1982 • 49 citations

Calcium ion activation of rabbit liver alpha 1,2-mannosidase.

1990 • 46 citations

Oligopeptide inhibitors of metalloendoprotease activity inhibit catecholamine secretion from bovine adrenal chromaffin cells by modulating intracellular calcium homeostasis.

1987 • 30 citations

Dipeptide metalloendoprotease substrates are glucose transport inhibitors and membrane structure perturbants

1986 • 28 citations

Effects of Ca2+ and ionophore A23187 on protein synthesis in intact rabbit reticulocytes

1991 • 24 citations

Inhibition of translational initiation by metalloendoprotease antagonists. Evidence for involvement of sequestered Ca2+ stores.

1991 • 23 citations

Stimulation of GRP78 gene transcription by phorbol ester and cAMP in GH3 pituitary cells. The accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium.

1991 • 23 citations

Metalloendoprotease inhibitors block protein synthesis, intracellular transport, and endocytosis in hepatoma cells.

1988 • 18 citations