Activation of T84 cell chloride channels by carbachol involves a phosphoinositide-coupled muscarinic M3 receptor

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.

1989 • 627 citations

A human colonic tumor cell line that maintains vectorial electrolyte transport

1984 • 398 citations

Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat

1986 • 373 citations

Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells

1987 • 341 citations

Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line.

1986 • 321 citations

A COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE‐SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA‐PIG ATRIAL PACEMAKER CELLS AT 29°C AND IN ILEUM AT 29°C AND 37°C

1976 • 292 citations

Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist

1986 • 283 citations

Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]

1976 • 244 citations

Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase

1991 • 192 citations

A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells

1990 • 169 citations

Active chloride secretion by rabbit colon: Calcium-dependent stimulation by ionophore A23187

1977 • 160 citations

Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.

1988 • 145 citations

Characterization of a cyclic AMP-activated Cl-transport pathway in the apical membrane of a human colonic epithelial cell line.

1986 • 126 citations

AF-DX 116, a cardioselective muscarinic antagonist.

1987 • 116 citations

Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes

1989 • 108 citations

Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells.

1991 • 99 citations

Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase.

1984 • 95 citations

Intracellular calcium release mediated by two muscarinic receptor subtypes

1988 • 85 citations

Kinetic studies of [3H]-N-methylscopolamine binding to muscarinic receptors in the rat central nervous system: evidence for the existence of three classes of binding sites.

1986 • 66 citations

Improved two-dimensional solvent system for thin-layer chromatographic analysis of polar lipids on silica gel 60 precoated plates

1978 • 66 citations

Human HT-29 colon carcinoma cells contain muscarinic M3 receptors coupled to phosphoinositide metabolism

1989 • 54 citations

Cloned muscarinic receptor subtypes expressed in A9 L cells differ in their coupling to electrical responses.

1988 • 52 citations

Functional diversity of muscarinic receptor subtypes in cellular signal transduction and growth.

1989 • 42 citations

Selective effector coupling of muscarinic acetylcholine receptor subtypes.

1989 • 35 citations

Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems

1987 • 34 citations

Carbachol-induced cytosolic free Ca2+ increases in T84 colonic cells seen by microfluorimetry

1989 • 29 citations

Different antagonist binding properties of rat pancreatic and cardiac muscarinic receptors

1987 • 27 citations

Role of calcium in mediating action of carbachol in T84 cells

1989 • 25 citations

RHC 80267 inhibits thyrothopin-stimulated prostaglandin release from rat thyroid lobes

1984 • 17 citations

Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.

1988 • 7 citations

Effects of (1,6-di (O-carbamoyl)cyclohexanone oxime)hexane (RHC 80267) on prostaglandin biosynthesis and accumulation of diacylglycerol and arachidonic acid in rabbit iris

1985 • 6 citations