Phenotypically and Functionally Distinct CD8+ Lymphocyte Populations in Long-Term Drug-Free Tolerance and Chronic Rejection in Human Kidney Graft Recipients

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Diagnosis of multiple cancer types by shrunken centroids of gene expression

2002 • 2,932 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

2003 • 1,563 citations

Roles of the NKG2D immunoreceptor and its ligands

2003 • 1,297 citations

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

2003 • 999 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

Noninvasive Diagnosis of Renal-Allograft Rejection by Measurement of Messenger RNA for Perforin and Granzyme B in Urine

2001 • 600 citations

Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

2003 • 582 citations

Heterologous immunity provides a potent barrier to transplantation tolerance

2003 • 565 citations

Tolerogenic immunosuppression for organ transplantation

2003 • 499 citations

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

2000 • 446 citations

Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes.

1999 • 439 citations

Specific suppression of T helper alloreactivity by allo-MHC class I- restricted CD8+CD28- T cells

1998 • 271 citations

Immediate Cytotoxicity But Not Degranulation Distinguishes Effector and Memory Subsets of CD8+ T Cells

2004 • 265 citations

Analyses of Peripheral Blood Mononuclear Cells in Operational Tolerance After Pediatric Living Donor Liver Transplantation

2004 • 263 citations

Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

2003 • 262 citations

Alloantigen specific CD8+CD28− FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity

2004 • 257 citations

Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation☆

1999 • 253 citations

Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future

2004 • 229 citations

Identification of Naive or Antigen-Experienced Human CD8+ T Cells by Expression of Costimulation and Chemokine Receptors: Analysis of the Human Cytomegalovirus-Specific CD8+ T Cell Response

2002 • 216 citations

Heterologous immunity: an overlooked barrier to tolerance

2003 • 216 citations

Modulation of CD28 Expression: Distinct Regulatory Pathways During Activation and Replicative Senescence

1999 • 204 citations

Resistance to Apoptosis and Elevated Expression of Bcl-2 in Clonally Expanded CD4+CD28− T Cells from Rheumatoid Arthritis Patients

1998 • 192 citations

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions

2003 • 191 citations

Evidence that human CD8+CD45RA+CD27– cells are induced by antigen and evolve through extensive rounds of division

1999 • 190 citations

Specific Suppression of Human CD4+ Th Cell Responses to Pig MHC Antigens by CD8+CD28− Regulatory T Cells

1998 • 188 citations

Faces and phases of human CD8+ T-cell development

1999 • 187 citations

Mixed Chimerism and Transplantation Tolerance

2001 • 184 citations

Clonality and Longevity of CD4+CD28null T Cells Are Associated with Defects in Apoptotic Pathways

2000 • 173 citations

T Cells Primed byLeishmania majorInfection Cross-React with Alloantigens and Alter the Course of Allograft Rejection

2002 • 158 citations

Restoration of CD28 Expression in CD28− CD8+ Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production

2003 • 140 citations

Human CD28−CD8+ T Cells Contain Greatly Expanded Functional Virus-Specific Memory CTL Clones

1999 • 137 citations

Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8+CD57+CD28− compartment

2001 • 133 citations

TCR Specificity Dictates CD94/NKG2A Expression by Human CTL

2002 • 126 citations

Regulatory CD8+CD28− T cells in heart transplant recipients

2002 • 117 citations

Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28− T suppressor cells

2004 • 113 citations

Serial Peripheral Blood Perforin and Granzyme B Gene Expression Measurements for Prediction of Acute Rejection in Kidney Graft Recipients

2003 • 112 citations

Progressive decrease of CD8high+ CD28+ CD57− cells with ageing

1998 • 107 citations

Mixed chimerism and transplantation tolerance

2004 • 99 citations

The regulation of lymphocyte activation by inhibitory receptors

2004 • 98 citations

Operationally Tolerant and Minimally Immunosuppressed Kidney Recipients Display Strongly Altered Blood T-Cell Clonal Regulation

2005 • 96 citations

Alloreactivity in Renal Transplant Recipients with and without Chronic Allograft Nephropathy

2004 • 92 citations

Mouse Vascular Endothelium Activates CD8+ T Lymphocytes in a B7-Dependent Fashion

2002 • 79 citations

Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis

2005 • 79 citations

Modulation of Tissue-Specific Immune Response to Cardiac Myosin Can Prolong Survival of Allogeneic Heart Transplants

2002 • 69 citations

Perforin Mediates Endothelial Cell Death and Resultant Transplant Vascular Disease in Cardiac Allografts

2004 • 64 citations

HYPERLIPIDEMIA AND CARDIOVASCULAR DISEASE AFTER ORGAN TRANSPLANTATION

2001 • 55 citations

Role of CD8+ lymphocytes in chronic rejection of transplanted hearts

2002 • 53 citations

Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.

2001 • 40 citations

Epitope Mapping of the Indirect T Cell Response to Allogeneic Class I MHC: Sequences Shared by Donor and Recipient MHC May Prime T Cells That Provide Help for Alloantibody Production

2001 • 25 citations

CHRONIC REJECTION OF MURINE CARDIAC ALLOGRAFTS DISCORDANT AT THE H13 MINOR HISTOCOMPATIBILITY ANTIGEN CORRELATES WITH THE GENERATION OF THE H13-SPECIFIC CD8+ CYTOTOXIC T CELLS1

2003 • 25 citations

THE USE OF GRANZYME A AS A MARKER OF HEART TRANSPLANT REJECTION IN CYCLOSPORINE OR ANTI-CD4 MONOCLONAL ANTIBODY-TREATED RATS

1993 • 18 citations

Toward tolerance to human organ transplants: a few additional corollaries and questions1

2004 • 12 citations

INDUCTION OF ANTIGRAFT AND ANTIRECIPIENT ANTIBODY RESPONSES AFTER FULLY ALLOGENEIC AND SEMIALLOGENEIC RAT SMALL BOWEL TRANSPLANTATION

2001 • 5 citations