ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

Receptors for Purines and Pyrimidines

2012 • 4,065 citations

Mechanisms of resistance to cisplatin

2001 • 849 citations

International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.

2001 • 639 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

Molecular pharmacology of P2Y-receptors

2000 • 490 citations

Purinergic Signalling: Pathophysiological Roles

1998 • 445 citations

Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium

1991 • 317 citations

Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation

1997 • 286 citations

Extracellular ATP Activates Transcription Factor NF-κB through the P2Z Purinoreceptor by Selectively Targeting NF-κB p65 (RelA)

1997 • 284 citations

CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli

1997 • 263 citations

Cell to Cell Communication in Response to Mechanical Stress via Bilateral Release of Atp and Utp in Polarized Epithelia

2000 • 248 citations

Bioluminescence detection of ATP release mechanisms in epithelia

1998 • 242 citations

Adenosine Triphosphate

1999 • 218 citations

Mitogenic Signaling by ATP/P2Y Purinergic Receptors in Astrocytes: Involvement of a Calcium-Independent Protein Kinase C, Extracellular Signal-Regulated Protein Kinase Pathway Distinct from the Phosphatidylinositol-Specific Phospholipase C/Calcium Pathway

1999 • 203 citations

P2Y₁₃: Identification and Characterization of a Novel Gαi-Coupled ADP Receptor from Human and Mouse

2002 • 163 citations

Cystic Fibrosis Transmembrane Regulator-independent Release of ATP

1998 • 162 citations

Mechanical strain-induced Ca²⁺waves are propagated via ATP release and purinergic receptor activation

2000 • 143 citations

UTP as an Extracellular Signaling Molecule

2001 • 134 citations

IL-4 Is a Potent Modulator of Ion Transport in the Human Bronchial Epithelium In Vitro

2002 • 132 citations

Nucleotide Regulation of Goblet Cells in Human Airway Epithelial Explants: Normal Exocytosis in Cystic Fibrosis

1993 • 127 citations

PKC‐ and ERK‐dependent activation of IκB kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor‐mediated CaMK activation

2001 • 126 citations

Use of an ex vivo ATP luminescence assay to direct chemotherapy for recurrent ovarian cancer

1998 • 122 citations

Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells

2001 • 117 citations

Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors

1996 • 117 citations

Multiple modes of regulation of airway epithelial chloride secretion by extracellular ATP

1994 • 107 citations

Calcium, Calmodulin, and CaMKII Requirement for Initiation of Centrosome Duplication in Xenopus Egg Extracts

2002 • 101 citations

Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y2-receptors

2002 • 97 citations

Intercellular Ca²⁺signaling in alveolar epithelial cells through gap junctions and by extracellular ATP

2001 • 93 citations

Dexamethasone and Tumor Necrosis Factor-α Act Together to Induce the Cellular Inhibitor of Apoptosis-2 Gene and Prevent Apoptosis in a Variety of Cell Types

2002 • 92 citations

P2Y₂ receptor‐mediated proliferation of C₆ glioma cells via activation of Ras/Raf/MEK/MAPK pathway

2000 • 92 citations

Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate

2001 • 92 citations

Extracellular ATP and ADP Activate Transcription Factor NF-κB and Induce Endothelial Cell Apoptosis

1998 • 91 citations

Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells

2000 • 89 citations

UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y₆receptors

2002 • 86 citations

Modulation of Interleukin-1β and Tumor Necrosis Factor α Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes

2000 • 81 citations

Intracellular calcium oscillations induced by ATP in airway epithelial cells

1999 • 70 citations

Cytokines Induce Upregulation of Vascular P2Y ₂ Receptors and Increased Mitogenic Responses to UTP and ATP

2000 • 64 citations

Evidence supporting the Nucleotide Axis Hypothesis: ATP release and metabolism by coronary endothelium

2001 • 63 citations

Secreted and Cell-Associated Adenylate Kinase and Nucleoside Diphosphokinase Contribute to Extracellular Nucleotide Metabolism on Human Airway Surfaces

2002 • 63 citations

P2Y₂ nucleotide receptor signaling in human monocytic cells: Activation, desensitization and coupling to mitogen‐activated protein kinases

2001 • 60 citations

Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y₂ purinoceptor in renal mesangial cells

2002 • 58 citations

Activation of the Tumor Metastasis Suppressor Gene, KAI1, by Etoposide Is Mediated by p53 and c-Jun Genes

2000 • 52 citations

Evidence That Gα_q-Coupled Receptor-Induced Interleukin-6 mRNA in Vascular Smooth Muscle Cells Involves the Nuclear Factor of Activated T Cells

2000 • 49 citations

Expression and Responsiveness of P2Y₂Receptors in Human Endometrial Cancer Cell Lines

1999 • 47 citations

Generation of extracellular atp in blood and its mediated inhibition of host weight loss in tumor-bearing mice

1989 • 45 citations

Repression of Cyclin B1 Expression after Treatment with Adriamycin, but Not Cisplatin in Human Lung Cancer A549 Cells

2001 • 42 citations

Regulation of K⁺ current in human airway epithelial cells by exogenous and autocrine adenosine

2001 • 40 citations

Interaction between novel anticancer agents and radiation in non-small cell lung cancer cell lines

2001 • 23 citations

Evidence for a G protein-coupled diadenosine-5′,5‴-P1,P4-tetraphosphate (Ap4A) receptor binding site in lung membranes from rat

1999 • 10 citations

Physiological evidence for a P2Y receptor responsive to diadenosine polyphosphates in human lung via Ca2+ release studies in bronchial epithelial cells

2001 • 10 citations