International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

2000 • 1,016 citations

A P2X purinoceptor expressed by a subset of sensory neurons

1995 • 1,014 citations

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1995 • 988 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

Altered Cytokine Production in Mice Lacking P2X7Receptors

2001 • 918 citations

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1996 • 882 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1987 • 786 citations

Pharmacology of Cloned P2X Receptors

2000 • 701 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

1998 • 540 citations

The Permeabilizing ATP Receptor, P2X7

1997 • 486 citations

Tissue distribution of the P2X7 receptor

1997 • 481 citations

Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin

1997 • 477 citations

Distinct ATP receptors on pain-sensing and stretch-sensing neurons

1997 • 452 citations

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

2000 • 450 citations

Signalling via ATP in the nervous system

1994 • 441 citations

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals

1997 • 418 citations

Hetero-oligomeric Assembly of P2X Receptor Subunits

1999 • 411 citations

Pore dilation of neuronal P2X receptor channels

1999 • 408 citations

Adenine Nucleotides Undergo Rapid, Quantitative Conversion to Adenosine in the Extracellular Space in Rat Hippocampus

1997 • 406 citations

Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry.

1996 • 405 citations

An antagonist-insensitive P2X receptor expressed in epithelia and brain.

1996 • 404 citations

Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors

2000 • 391 citations

ATP excites a subpopulation of rat dorsal horn neurones

1983 • 389 citations

P2X receptors in sensory neurones

2000 • 377 citations

Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds

1999 • 355 citations

ION CHANNELS OF NOCICEPTION

1999 • 349 citations

Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X₇ receptor

1999 • 345 citations

P2X4: an ATP-activated ionotropic receptor cloned from rat brain.

1996 • 339 citations

Receptor for ATP in the membrane of mammalian sensory neurones

1983 • 335 citations

Mapping the conformational wave of acetylcholine receptor channel gating

2000 • 329 citations

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

1998 • 308 citations

Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor

1997 • 306 citations

A P2X purinoceptor cDNA conferring a novel pharmacological profile

1995 • 279 citations

Allosteric Control of Gating and Kinetics at P2X₄Receptor Channels

1999 • 279 citations

P2x receptors bring new structure to ligand-gated ion channels

1995 • 277 citations

Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.

1998 • 271 citations

Ionic permeability of, and divalent cation effects on, two ATP‐gated cation channels (P2X receptors) expressed in mammalian cells.

1996 • 257 citations

ATP induces nucleotide permeability in rat mast cells

1979 • 252 citations

Central P2X₄and P2X₆Channel Subunits Coassemble into a Novel Heteromeric ATP Receptor

1998 • 246 citations

A unifying purinergic hypothesis for the initiation of pain

1996 • 241 citations

Characterization of Recombinant Human P2X₄ Receptor Reveals Pharmacological Differences to the Rat Homologue

1997 • 220 citations

Isoquinolines as Antagonists of the P2X₇Nucleotide Receptor: High Selectivity for the Human versus Rat Receptor Homologues

1998 • 218 citations

How Cells Make ATP

1978 • 209 citations

Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor

2000 • 208 citations

Identification of amino acid residues contributing to the pore of a P2X receptor

1997 • 207 citations

A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain.

1996 • 205 citations

Electrophysiological properties of P2X‐purinoceptors in rat superior cervical, nodose and guinea‐pig coeliac neurones.

1995 • 200 citations

The Role of Positively Charged Amino Acids in ATP Recognition by Human P2X1 Receptors

2000 • 188 citations

State-dependent cross-inhibition between transmitter-gated cation channels

2000 • 186 citations

Cell type‐specific ATP‐activated responses in rat dorsal root ganglion neurons

1999 • 181 citations

Different Sensitivities to pH of ATP-Induced Currents at Four Cloned P2X Receptors

1997 • 181 citations

Acute nociception mediated by hindpaw P2X receptor activation in the rat

1997 • 180 citations

Cationic channels activated by extracellular atp in rat sensory neurons

1988 • 174 citations

Vasoconstriction of guinea‐pig submucosal arterioles following sympathetic nerve stimulation is mediated by the release of ATP

1992 • 168 citations

Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes.

1994 • 168 citations

Single Channel Properties of P2X2 Purinoceptors

1999 • 166 citations

Presynaptic P2X Receptors Facilitate Inhibitory GABAergic Transmission between Cultured Rat Spinal Cord Dorsal Horn Neurons

2000 • 164 citations

Expression of the P2X₂Receptor Subunit of the ATP-Gated Ion Channel in the Cochlea: Implications for Sound Transduction and Auditory Neurotransmission

1999 • 163 citations

How should P2x purinoceptors be classified pharmacologically?

1995 • 163 citations

Desensitization of the P2X₂ receptor controlled by alternative splicing

1997 • 160 citations

P2X Receptor–Mediated Ionic Currents in Dorsal Root Ganglion Neurons

1999 • 160 citations

Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels

1995 • 156 citations

Coexpression of Rat P2X₂and P2X₆Subunits inXenopusOocytes

2000 • 154 citations

ATP‐activated channels gate calcium entry in single smooth muscle cells dissociated from rabbit ear artery.

1989 • 153 citations

An ATP‐sensitive conductance in single smooth muscle cells from the rat vas deferens.

1988 • 152 citations

Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors

1998 • 149 citations

Pharmacological characterization of ATP‐ and LPS‐induced IL‐1β release in human monocytes

1999 • 148 citations

Cloning and functional characterisation of the mouse P2X₇ receptor

1998 • 146 citations

Co-Expression of P2X₁ and P2X₅ Receptor Subunits Reveals a Novel ATP-Gated Ion Channel

1998 • 144 citations

ATP Stimulates Sympathetic Transmitter Release via Presynaptic P2X Purinoceptors

1999 • 144 citations

Localization and Functional Expression of Splice Variants of the P2X₂Receptor

1997 • 140 citations

Domains of P2X receptors involved in desensitization

1996 • 140 citations

Localization of P2X purinoceptor transcripts in the rat nervous system.

1995 • 139 citations

Characterization of cultured dorsal root ganglion neuron P2X receptors

1999 • 138 citations

Ion channel subconductance states

1987 • 136 citations

A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility method.

1998 • 136 citations

Properties of the pore‐forming P2X₇ purinoceptor in mouse NTW8 microglial cells

1997 • 132 citations

Action of externally applied adenosine triphosphate on single smooth muscle cells dispersed from rabbit ear artery.

1987 • 130 citations

Localization of P2X₁ purinoceptors by autoradiography and immunohistochemistry in rat kidneys

1998 • 128 citations

Molecular cloning and functional expression of a novel rat heart P2X purinoceptor

1996 • 126 citations

Calcium permeability and block at homomeric and heteromeric P2X₂ and P2X₃ receptors, and P2X receptors in rat nodose neurones

1998 • 126 citations

Baculovirus Expression Provides Direct Evidence for Heteromeric Assembly of P2X₂and P2X₃Receptors

1997 • 123 citations

Membrane Topology of an ATP-gated Ion Channel (P2X Receptor)

1998 • 121 citations

Two ATP-activated conductances in bullfrog atrial cells.

1988 • 120 citations

Contribution of Individual Subunits to the Multimeric P2X₂ Receptor: Estimates based on Methanethiosulfonate Block at T336C

1999 • 118 citations

Characterization of P2‐purinoceptors in the smooth muscle of the rat tail artery: a comparison between contractile and electrophysiological responses

1994 • 118 citations

Effects of antagonists at the human recombinant P2X₇ receptor

1998 • 116 citations

Calcium permeability of ligand-gated channels

1998 • 111 citations

The properties of the ATP‐induced depolarization and current in single cells isolated from the guinea‐pig urinary bladder

1990 • 111 citations

Mechanism of action of ATP on canine pulmonary vagal C fibre nerve terminals.

1996 • 111 citations

Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice

1999 • 110 citations

Cloning and Tissue Distribution of a Novel P2X Receptor from Rat Brain

1996 • 109 citations

Coexpression of mRNAs for P2X<sub>1</sub>, P2X<sub>2</sub> and P2X<sub>4</sub> Receptors in Rat Vascular Smooth Muscle: An in situ Hybridization and RT-PCR Study

1998 • 106 citations

P2X purinoceptors in cultured myenteric neurons of guinea‐pig small intestine.

1996 • 101 citations

The antagonist trinitrophenyl‐ATP reveals co‐existence of distinct P2X receptor channels in rat nodose neurones

1998 • 101 citations

Differential Modulation by Copper and Zinc of P2X₂and P2X₄ Receptor Function

1999 • 100 citations

Functional characterization of the P2X₄ receptor orthologues

2000 • 99 citations

Excitation of rat locus coeruleus neurons by adenosine 5'-triphosphate: ionic mechanism and receptor characterization

1993 • 99 citations

Characterization of a P_2X‐purinoceptor in cultured neurones of the rat dorsal root ganglia

1996 • 97 citations

Extracellular metabolism of nucleotides in the nervous system

1996 • 97 citations

Diinosine pentaphosphate (IP₅I) is a potent antagonist at recombinant rat P2X₁ receptors

1999 • 97 citations

Electron-immunocytochemical localization of P2X 1 receptors in the rat cerebellum

1998 • 94 citations

Functional and Biochemical Evidence for Heteromeric ATP-gated Channels Composed of P2X1 and P2X5Subunits

1999 • 93 citations

Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system

1997 • 92 citations

Dynamic Selectivity Filters in Ion Channels

1999 • 91 citations

Pharmacological properties of P2X₃‐receptors present in neurones of the rat dorsal root ganglia

1998 • 91 citations

Zn²⁺ modulation of ATP‐responses at recombinant P2X₂ receptors and its dependence on extracellular pH

1998 • 89 citations

Receptors for ATP in rat sensory neurones: the structure‐function relationship for ligands

1988 • 89 citations

ATP‐evoked increases in [Ca²⁺]_i and peptide release from rat isolated neurohypophysial terminals via a P_2X2 purinoceptor

1998 • 88 citations

Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat

1999 • 87 citations

2′,3′‐O‐(2,4,6‐ trinitrophenyl) adenosine 5′‐triphosphate (TNP‐ATP)–a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels

1998 • 87 citations

Contributions of the C-terminal Domain to the Control of P2X Receptor Desensitization

1999 • 83 citations

Electrical responses of smooth muscle cells of the rabbit ear artery to adenosine triphosphate.

1985 • 82 citations

Properties of the novel ATP-gated ionotropic receptor composed of the P2X(1) and P2X(5) isoforms.

1999 • 82 citations

P2X1 receptor activation in HL60 cells

1996 • 81 citations

Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats

1998 • 80 citations

The P2X1 Receptor, an Adenosine Triphosphate–Gated Cation Channel, Is Expressed in Human Platelets but not in Human Blood Leukocytes

1998 • 80 citations

New insights on P2X purinoceptors

1995 • 80 citations

Inhibition by suramin and reactive blue 2 of GABA and glutamate receptor channels in rat hippocampal neurons

1995 • 79 citations

An ATP-sensitive conductance in cultured smooth muscle cells from pregnant rat myometrium

1989 • 78 citations

Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors

1999 • 76 citations

Functional properties of heteromeric P2X1/5 receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles

2000 • 76 citations

Adenosine triphosphate-activated inward current in isolated smooth muscle cells from rat vas deferens

1987 • 75 citations

Effect of ivermectin on γ-aminobutyric acid-induced chloride currents in mouse hippocampal embryonic neurones

1994 • 74 citations

A Memory for Extracellular Ca²⁺by Speeding Recovery of P2X Receptors from Desensitization

1998 • 74 citations

Apparent species differences in the kinetic properties of P2X₇ receptors

2000 • 73 citations

Identification of Amino Acid Residues Contributing to Desensitization of the P2X2 Receptor Channel

1998 • 70 citations

Molecular Cloning and Characterization of a Novel ATP P2X Receptor Subtype from Embryonic Chick Skeletal Muscle

2000 • 70 citations

A study on P₂x purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens

1995 • 69 citations

Modulatory activity of extracellular H⁺ and Zn²⁺ on ATP‐responses at rP2X₁ and rP2X₃ receptors

1999 • 67 citations

Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X₃ and P2X_2/3 receptors and between two P2X receptors in rat sensory neurones

2000 • 66 citations

N-Linked Glycosylation Is Essential for the Functional Expression of the Recombinant P2X₂Receptor

1998 • 65 citations

Potentiation of ATP‐responses at a recombinant P_2X2 receptor by neurotransmitters and related substances

1997 • 64 citations

ATP‐gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurons of the rat.

1997 • 64 citations

Block by calcium of ATP-activated channels in pheochromocytoma cells.

1993 • 63 citations

Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons

1998 • 61 citations

Ca²⁺-Permeable P2X Receptor Channels in Cultured Rat Retinal Ganglion Cells

1999 • 61 citations

Molecular Assembly of the Extracellular Domain of P2X2, an ATP-Gated Ion Channel

1997 • 61 citations

Roles of Individual N-Glycans for ATP Potency and Expression of the Rat P2X1 Receptor

2000 • 60 citations

Inactivation of P2X₂ purinoceptors by divalent cations

2000 • 57 citations

Mutation of histidine 286 of the human P2X₄ purinoceptor removes extracellular pH sensitivity

2000 • 56 citations

Solubilization and molecular size determination of the P2x purinoceptor from rat vas deferens.

1992 • 55 citations

Ion Permeation and Block of P2X 2 Purinoceptors: Single Channel Recordings

1999 • 54 citations

P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells

2000 • 53 citations

Calcium Flux Through Predominantly Independent Purinergic ATP and Nicotinic Acetylcholine Receptors

1997 • 52 citations

Human neuronal threonine-for-leucine-248 alpha 7 mutant nicotinic acetylcholine receptors are highly Ca2+ permeable

2000 • 51 citations

P2X receptors mediate ATP-induced primary nociceptive neurone activation

2000 • 49 citations

The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β‐methylene adenosine 5′‐triphosphate

1994 • 49 citations

Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve

1993 • 49 citations

Identification of a P2X1Purinoceptor Expressed on Human Platelets

1998 • 48 citations

Colocalization of ATP and nicotinic ACh receptors in the identified vagal preganglionic neurone of rat.

1995 • 48 citations

Estimates of antagonist affinities at P2x purinoceptors in rat vas deferens

1994 • 47 citations

Functional characterisation of P2 purinoceptors in PC12 cells by measurement of radiolabelled calcium influx

1996 • 46 citations

The selective P2X purinoceptor agonist, ?,?-methylene-L-adenosine 5?-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors

1995 • 45 citations

Identification of amino acids within the P2X₂ receptor C‐terminus that regulate desensitization

1999 • 45 citations

Evidence that ATP acts at two sites to evoke contraction in the rat isolated tail artery

1998 • 44 citations

Guinea‐pig sympathetic neurons express varying proportions of two distinct P2X receptors

2000 • 43 citations

Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons

2000 • 42 citations

Radiolabeling of the rat P2X4 purinoceptor: evidence for allosteric interactions of purinoceptor antagonists and monovalent cations with P2X purinoceptors.

1997 • 39 citations

A comparison of the binding characteristics of recombinant P_2×1 and P_2×2 purinoceptors

1996 • 36 citations

Functional Expression of Three P2X₂ Receptor Splice Variants From Guinea Pig Cochlea

2000 • 35 citations

ATP-gated ion channel expression in primary auditory neurones

1999 • 35 citations

Comparison of P2X receptors in rat mesenteric, basilar and septal (coronary) arteries

2000 • 34 citations

Pharmacological and histochemical evidence for P2X receptors in human umbilical vessels

1998 • 33 citations

Cibacron blue allosterically modulates the rat P2X4 receptor

1998 • 32 citations

A role for calcineurin in the desensitization of the P2X3 receptor

1997 • 32 citations

Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.

1999 • 30 citations

Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors

2001 • 28 citations

Functional evidence for multiple purinoceptor subtypes in the rat medial vestibular nucleus

1997 • 27 citations

Novel Mechanism of Inhibition by the P2 Receptor Antagonist PPADS of ATP-Activated Current in Dorsal Root Ganglion Neurons

2000 • 26 citations

The regulation of pyruvate dehydrogenase activity in rat hippocampal slices: Effect of dichloroacetate

1982 • 24 citations

P2X2 characteristics of the ATP receptor coupled to [Ca2+]i increases in cultured Purkinje neurons from neonatal rat cerebellum

1999 • 24 citations

Rat chromaffin cells lack P2X receptors while those of the guinea‐pig express a P2X receptor with novel pharmacology

1999 • 22 citations

Zn2+ modulation of ATP-responses at recombinant P2X receptors: dependence on extracellular pH

1997 • 11 citations

The Leeuwenhoek Lecture, 1981 - The biochemical and genetic approach to the study of bioenergetics with the use of Escherichia coli : progress and prospects

1982 • 10 citations

The biochemical and genetic approach to the study of bioenergetics with the use of Escherichia coli: progress and prospects

1982 • 3 citations