Cell to Cell Communication in Response to Mechanical Stress via Bilateral Release of Atp and Utp in Polarized Epithelia

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease

1998 • 1,136 citations

Connexins regulate calcium signaling by controlling ATP release

1998 • 767 citations

ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes–possible sensory mechanism?

1997 • 653 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

The past, present and future of purine nucleotides as signalling molecules

1997 • 550 citations

Intercellular Propagation of Calcium Waves Mediated by Inositol Trisphosphate

1992 • 518 citations

Calcium Waves in Retinal Glial Cells

1997 • 461 citations

Coordinated clearance of periciliary liquid and mucus from airway surfaces.

1998 • 374 citations

Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells

1992 • 373 citations

Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells.

1990 • 363 citations

The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.

1994 • 354 citations

Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.

1996 • 348 citations

Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium

1991 • 317 citations

Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation

1997 • 286 citations

CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli

1997 • 263 citations

Cloning and Functional Expression of a Human Uridine Nucleotide Receptor

1995 • 250 citations

Identification of competitive antagonists of the P2Y1 receptor.

1996 • 245 citations

Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides.

1996 • 225 citations

Loss of Binding and Entry of Liposome-DNA Complexes Decreases Transfection Efficiency in Differentiated Airway Epithelial Cells

1997 • 195 citations

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene

1995 • 193 citations

Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP

1996 • 184 citations

Effect of Loss of P2Y2 Receptor Gene Expression on Nucleotide Regulation of Murine Epithelial Cl−Transport

1999 • 183 citations

Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model

1995 • 183 citations

Cystic Fibrosis Transmembrane Regulator-independent Release of ATP

1998 • 162 citations

Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.

1991 • 158 citations

Hf-W Isotopic Evidence for Rapid Accretion and Differentiation in the Early Solar System

1996 • 157 citations

Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist

1997 • 148 citations

Nucleotide-regulated Calcium Signaling in Lung Fibroblasts and Epithelial Cells from Normal and P2Y2 Receptor (−/−) Mice

1999 • 135 citations

Intercellular calcium signaling induced by extracellular adenosine 5′-triphosphate and mechanical stimulation in airway epithelial cells

1993 • 127 citations

Nucleotide Regulation of Goblet Cells in Human Airway Epithelial Explants: Normal Exocytosis in Cystic Fibrosis

1993 • 127 citations

Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors

1996 • 117 citations

UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y ₂ receptor

1997 • 113 citations

Intercellular Calcium Signaling via Gap Junction in Connexin-43-transfected Cells

1998 • 107 citations

Membrane-restricted regulation of Ca2+ release and influx in polarized epithelia

1995 • 101 citations

Propagation of Mechanically Induced Intercellular Calcium Waves via Gap Junctions and ATP Receptors in Rat Liver Epithelial Cells

1997 • 99 citations

The increase in the intracellular Ca2+ concentration induced by mechanical stimulation is propagated via release of pyrophosphorylated nucleotides in mammary epithelial cells

1994 • 98 citations

Mechanisms for the coordination of intercellular calcium signaling in insulin secreting cells

1997 • 89 citations

Cilia, Mucus, and Mucociliary Interactions

1998 • 81 citations

A role for Ca2+-conducting ion channels in mechanically-induced signal transduction of airway epithelial cells

1994 • 78 citations

Role of CNP in human airways: cGMP-mediated stimulation of ciliary beat frequency

1995 • 69 citations

Sequence-specific antibodies to connexins block intercellular calcium signaling through gap junctions

1998 • 68 citations

Stretch increases inositol 1,4,5-trisphosphate concentration in airway epithelial cells.

1996 • 63 citations

The cystic fibrosis transmembrane conductance regulator and ATP

1997 • 62 citations

Intercellular Waves of Communication

1996 • 58 citations

Role of proton pump of mitochondria‐rich cells for active transport of chloride ions in toad skin epithelium.

1992 • 51 citations

The Relationship of Chronic Mucin Secretion to Airway Disease in Normal and CFTR-Deficient Mice

1998 • 48 citations

Design of Retroviral Expression Vectors

2003 • 30 citations

Mechanical Stimulation Initiates Intercellular Ca^{2 +} Signaling in Intact Tracheal Epithelium Maintained under Normal Gravity and Simulated Microgravity

1998 • 22 citations

Dynamics of Intercellular Communication and Differentiation in a Rapidly Developing Mammalian Airway Epithelium

1989 • 11 citations

Deleted Work

1955 • 0 citations