Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2

Coordination of circadian timing in mammals

2002 • 4,132 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker

1999 • 1,589 citations

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

1999 • 1,558 citations

Molecular Analysis of Mammalian Circadian Rhythms

2001 • 1,428 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

Time zones: a comparative genetics of circadian clocks

2001 • 1,142 citations

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

2001 • 1,113 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock

2004 • 1,046 citations

MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization

2004 • 953 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

1997 • 883 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

2005 • 828 citations

System-level identification of transcriptional circuits underlying mammalian circadian clocks

2005 • 765 citations

The mPer2 gene encodes a functional component of the mammalian circadian clock

1999 • 692 citations

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

2006 • 572 citations

Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans

1999 • 558 citations

Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation

2005 • 467 citations

Temporal phosphorylation of the Drosophila period protein.

1994 • 410 citations

Transcriptional oscillation of canonical clock genes in mouse peripheral tissues.

2004 • 297 citations

All's well that ends dead

1999 • 293 citations

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

2002 • 282 citations

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

2002 • 267 citations

Clock Genes, Oscillators, and Cellular Networks in the Suprachiasmatic Nuclei

2004 • 250 citations

The mammalian circadian clock

2003 • 228 citations

[49] Derivation of embryonic stem cell lines

1993 • 228 citations

An opposite role for tau in circadian rhythms revealed by mathematical modeling

2006 • 172 citations

Molecular Analysis of Mammalian Timeless

1998 • 169 citations

Posttranscriptional and Posttranslational Regulation of Clock Genes

2004 • 167 citations

The Doubletime and CKII Kinases Collaborate to Potentiate Drosophila PER Transcriptional Repressor Activity

2004 • 154 citations

Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2

2002 • 149 citations

Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2

2001 • 144 citations

A Rhythmic Ror

2004 • 123 citations

Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period

1996 • 115 citations

Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts

2004 • 61 citations

Nucleocytoplasmic Shuttling of Clock Proteins

2005 • 60 citations

Role of Cyclic mPer2 Expression in the Mammalian Cellular Clock

2005 • 59 citations